公开(公告)号：ID28955A

公开(公告)日：2001-07-19

申请号：ID20010645

申请日：1999-08-13

Applicant: BASF AG CS

Inventor： ALLEN HAMISH JOHN ,  DIXON RICHARD W ,  KAMENS JOANNE S ,  WICKRAMASINGHE DINELI ,  XU YAJUN ,  BELICH MONICA P ,  JOHNSTON LELAND H ,  LEY STEVEN C ,  SALMERON ANDRES

IPC: C12N15/09 ,  A61K31/00 ,  A61K31/4439 ,  A61K31/4706 ,  A61K31/4745 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P1/00 ,  A61P3/10 ,  A61P5/48 ,  A61P17/06 ,  A61P29/00 ,  C07K14/82 ,  C07K16/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N15/54 ,  C12Q1/02 ,  G01N33/68 ,  A61K38/45 ,  G01M33/50 ,  A61K31/47 ,  A61K31/44

Abstract: It is shown that TPL-2 is responsible for phosphorylation of p105 and its resultant proteolysis, which leads to p50 Rel translocation to the nucleus. Accordingly, the invention provides TPL-2 as a specific regulator of the activation of NFkappaB, and thus as a modulator of inflammatory responses in which p105 is involved, and as a target for the development of compounds capable of influencing NFkappaB activation.