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    Substituted 5-phenyl pyrimidines I in therapy
    1.
    发明专利
    Substituted 5-phenyl pyrimidines I in therapy 未知

    公开(公告)号：AU2006208621B2

    公开(公告)日：2011-08-11

    申请号：AU2006208621

    申请日：2006-01-30

    Applicant: BASF SE

    Inventor： FRANK SCHIEWECK ,  BARBARA NAVE ,  THOMAS GROTE ,  BERND MULLER ,  JOACHIM RHEINHEIMER ,  CARSTEN BLETTNER ,  THORSTEN JABS ,  ANJA SCHWOGLER

    IPC: C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04

    Abstract: The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NRR, OR or SR, in which R, R, independently of each other, denote hydrogen, C-C-alkyl, C-C-alkenyl, C-C-alkynyl, C-C-haloalkyl, C-C-cycloalkyl, C-C-halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals R; or the radical NRR may also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NRR, in which two adjacent C atoms or one N atom and one adjacent C atom can be linked by a C-C-alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals R as defined in claim 1, R has one of the meanings given for R except for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, C-C-alkyl, C-C-alkenyl, C-C-alkynyl, C-C-cycloalkyl, C-C-alkoxy, C-C-alkenyloxy, C-C-alkynyloxy, C-C-alkylthio, di-(C-C-alkyl)amino or C-C-alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, C-C-alkoxy or C-C-alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases.

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