Abstract:
In a process for the accelerated reduction of organic substrates, selected from the group consisting of ester, amides, nitriles, acids, ketones, imines or mixtures thereof, the substrates are reacted with an amine borane, sulfide borane or ether borane complex as a borane source in the presence of organic accelerator compounds containing both Lewis acidic and Lewis basic sites in their structure, of which the Lewis acidic site can coordinate with the carbonyl or nitrile or imine group of the substrate and the Lewis basic site can coordinate with the borane.
Abstract:
In a process for the accelerated reduction of organic substrates, selected from the group consisting of esters, amides, nitriles, acids, ketones, imines or mixtures thereof, they are reacted with an amine borane, sulfide borane or ether borane complex as a borane source in the presence of organic accelerator compounds containing either Lewis acidic or Lewis basic sites in their structure, of which the Lewis acidic site can coordinate with the carbonyl or nitrile or imine group of the substrate or the Lewis basic site can coordinate with the borane.
Abstract:
24 Abstract ACCELERATED REDUCTION OF ORGANIC SUBSTANCES WITH BORANESIn a process for the accelerated reduction of organic substrates, selected from the group consisting of ester, amides, nitriles, acids, ketones, imines or mixtures thereof, the substrates are reacted with an amine borane, sulfide borane or ether borane complex as a borane source in the presence of organic accelerator compounds containing both Lewis acidic and Lewis basic sites in their structure, of which the Lewis acidic site can coordinate with the carbonyl or nitrile or imine group of the substrate and the Lewis basic site can coordinate with the borane.No suitable figure
Abstract:
Complejos boránicos de fórmula (1) **Fórmula** en donde R1 y R2 representan independientemente entre sí alquilo C1-C8, alcoxi C1-C8, alcoxi(C1-C8)-alquilo(C1-C8) o halógeno, con la condición de que R1 y R2 no sean al mismo tiempo metilo cuando R2 está en la posición 4 o 6 del anillo de piridina.
Abstract:
The present invention relates to a borane ether complex of the formula 1, wherein R1 to R4 represent independently from each other hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl or a substituent of the formula CH2OR5, wherein R5 is C1-C4-alkyl or C3-C6-cycloalkyl, or two adjacent substituents R1 to R4 together are a divalent group selected from the group consisting of -CH2CH2-, -CH(CH3)CH2-, -CH2CH2CH2-, -CH(CH3)CH(CH3)-, -CH(CH2CH3)CH2-, -C(CH3)2C(CH3)2-, -CH2C(CH3)2CH2- and -(CH2)6- to form with the -CH-CH- moiety of the tetrahydrofuran ring a cyclic structure, with the provision that at least one of the substituents R1 to R4 is not hydrogen. The invention also relates to a method of using new borane complexes with substituted tetrahydrofuran ethers for organic reactions.
Abstract:
Un procedimiento para la preparación de dialcoxiorganoboranos (3) de la fórmula R 1 -B(OR 2 ) 2, que comprende la etapa de hacer reaccionar una triorganoboroxina (1) de la fórmula (R 1 -BO)3 y un trialquilborato (2) de la fórmula B (OR 2 )3, en las que R 1 es alquilo C1-C20, cicloalquilo C3-C10, arilo C6-C14, aralquilo C7-C24, alcarilo C7-C24, alquenilo C2-C20, cicloalquenilo C5-C15, alquinilo C2-C20, CH2SiMe3, alquilo C1-C20 sustituido y R 2 es alquilo C1-C20, o dos grupos R 2 en los compuestos (2) o (3) junto con el resto -BO 2- forman una estructura cíclica de la fórmula con el grupo divalente R 3 seleccionado del grupo que consiste en -CH 2CH 2-, -CH(CH 3)CH 2-, -CH 2CH 2CH 2-, -CH (CH 3)CH(CH 3)-, -CH(CH 2CH 3)CH 2-, -C(CH 3) 2C(CH 3) 2-, -CH 2C(CH 3) 2CH 2-, -(CH 2) 6-, orto-C 6H 4 u orto-C 6H 3-alquilo.
Abstract:
The present invention relates to a borane ether complex of the formula 1, wherein R1 to R4 represent independently from each other hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl or a substituent of the formula CH2OR5, wherein R5 is C1-C4-alkyl or C3-C6-cycloalkyl, or two adjacent substituents R1 to R4 together are a divalent group selected from the group consisting of -CH2CH2-, -CH(CH3)CH2-, -CH2CH2CH2-, -CH(CH3)CH(CH3)-, -CH(CH2CH3)CH2-, -C(CH3)2C(CH3)2-, -CH2C(CH3)2CH2- and -(CH2)6- to form with the -CH-CH- moiety of the tetrahydrofuran ring a cyclic structure, with the provision that at least one of the substituents R1 to R4 is not hydrogen. The invention also relates to a method of using new borane complexes with substituted tetrahydrofuran ethers for organic reactions.
Abstract:
The invention relates to new processes to prepare low odor dialkyl sulfides, the low odor dialkyl sulfides obtainable by these processes and to methods of using these low odor dialkyl sulfides. Moreover, the invention relates to a process to prepare dialkyl sulfide borane complexes of high purity, the dialkyl sulfide borane complexes obtainable by this process and to a process for enantioselective reductions employing these dialkyl sulfide borane complexes of high purity as reducing agent. The process comprises bringing a dialkyl sulfide into contact with a base, and/or at least one alkali or alkaline earth metal. The base may be a metal alcoholate a metal oxide, a metal or alkylammonium hydroxide, a metal or alkylammonium carbonate, a metal enolate, a metal amide or a metal hydride. The process may contain a step of reacting the product with an electrophile and a further step of distilling out the dialkyl sulfide.