公开(公告)号：US10328150B2

公开(公告)日：2019-06-25

申请号：US15362957

申请日：2016-11-29

Applicant: BASF SE

Inventor： Karl Kolter ,  Dejan Djuric ,  Stefan Fischer

IPC: C08F283/06 ,  A61K9/20 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38 ,  A61K31/55 ,  A61K31/192 ,  A61K31/216 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/635 ,  A61K31/4164 ,  A61K31/4425 ,  A61K31/5415

Abstract: Dosage forms comprising preparations of slightly water-soluble active substances in a polymer matrix of polyether copolymers, the polyether copolymers being obtained by free radical polymerization of a mixture of from 30 to 80% by weight of N-vinyllactam, from 10 to 50% by weight of vinyl acetate and from 10 to 50% by weight of a polyether, and of at least one slightly water-soluble polymer in which the slightly water-soluble active substance is present in amorphous form in the polymer matrix.

公开(公告)号：US20150038668A1

公开(公告)日：2015-02-05

申请号：US14499528

申请日：2014-09-29

Applicant: BASF SE

Inventor： Dejan Djuric ,  Monika Haberecht ,  Karl Kolter ,  Bernd Bruchmann

IPC: C08G63/133

CPC classification number: C08G63/133 ,  A61K9/146 ,  A61K9/1641 ,  A61K9/1676 ,  A61K9/2031 ,  A61K9/7007 ,  C08G63/12 ,  C08G63/85

Abstract: Branched polyesters obtained by polycondensation of citric acid with at least one poly-alcohol having at least two hydroxyl groups and, if desired, further polycarboxylic acid components, the molar ratio of citric acid to polyalcohol being 2.4:1 to 1:3.

Abstract translation: 通过柠檬酸与至少一种具有至少两个羟基的多元醇缩聚获得的支化聚酯，以及如果需要，进一步的多元羧酸组分，柠檬酸与多元醇的摩尔比为2.4:1至1:3。

公开(公告)号：US20170072059A1

公开(公告)日：2017-03-16

申请号：US15362957

申请日：2016-11-29

Applicant: BASF SE

Inventor： Karl Kolter ,  Dejan Djuric ,  Stefan Fischer

IPC: A61K47/38 ,  A61K47/32 ,  A61K31/635 ,  A61K31/192 ,  A61K31/496 ,  A61K31/4425 ,  A61K31/495 ,  A61K31/55 ,  A61K31/451 ,  A61K31/4164 ,  A61K31/5415 ,  A61K47/34 ,  A61K31/216

CPC classification number: A61K47/38 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/192 ,  A61K31/216 ,  A61K31/4164 ,  A61K31/4425 ,  A61K31/451 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/635 ,  A61K47/32 ,  A61K47/34 ,  C08F283/06

Abstract: Dosage forms comprising preparations of slightly water-soluble active substances in a polymer matrix of polyether copolymers, the polyether copolymers being obtained by free radical polymerization of a mixture of from 30 to 80% by weight of N-vinyllactam, from 10 to 50% by weight of vinyl acetate and from 10 to 50% by weight of a polyether, and of at least one slightly water-soluble polymer in which the slightly water-soluble active substance is present in amorphous form in the polymer matrix.

Abstract translation: 在聚醚共聚物的聚合物基质中包含微溶于水的活性物质的制剂的剂量形式，所述聚醚共聚物通过将30至80重量％的N-乙烯基内酰胺的混合物自由基聚合，10至50重量％的N-乙烯基内酰胺 乙酸乙烯酯的重量和10至50重量％的聚醚，以及至少一种轻微水溶性聚合物，其中微溶于水的活性物质以无定形形式存在于聚合物基质中。