公开(公告)号：AT530639T

公开(公告)日：2011-11-15

申请号：AT02746888

申请日：2002-07-03

Applicant: BASF SE

Inventor： YOCUM R ,  PATTERSON THOMAS ,  PERO JANICE ,  HERMANN THERON

IPC: C12N9/10 ,  C12N15/09 ,  C07C235/12 ,  C07H21/04 ,  C12N1/20 ,  C12N1/21 ,  C12N9/02 ,  C12N9/04 ,  C12N9/88 ,  C12N15/03 ,  C12N15/10 ,  C12N15/52 ,  C12P13/02 ,  C12P13/04 ,  C12R1/125

Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.

公开(公告)号：BRPI0614891A2

公开(公告)日：2012-12-25

申请号：BRPI0614891

申请日：2006-08-18

Applicant: BASF SE

Inventor： ZELDER OSKAR ,  SCHROEDER HARTWIG ,  KROEMER JENS ,  PERO JANICE ,  YOCUM ROGERS ,  PATTERSON THOMAS ,  WILLIAMS MARK ,  HEROLD ANDREA ,  KLOPPROGGE CORINNA ,  HAEFNER STEFAN ,  HEINZLE ELMAR ,  WITTMANN CHRISTOPH ,  HERMANN THERON

IPC: C12N15/52 ,  C12P13/12 ,  C12R1/13 ,  C12R1/19

Abstract: The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.