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    POLYPEPTIDE AGENTS IN THE FORM OF CONJUGATES OF KERATIN-BINDING POLYPEPTIDES, POLYMERS, AND EFFECTOR MOLECULES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF
    1.
    发明申请
    POLYPEPTIDE AGENTS IN THE FORM OF CONJUGATES OF KERATIN-BINDING POLYPEPTIDES, POLYMERS, AND EFFECTOR MOLECULES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF 审中-公开
    多肽偶联物从角蛋白多肽，聚合物和执行方法的形式用于生产和使用

    公开(公告)号：WO2009112301A3

    公开(公告)日：2009-12-10

    申请号：PCT/EP2009050847

    申请日：2009-01-26

    Applicant: BASF SE ,  VOELKERT MARTIN ,  FEHR MARCUS ,  BRUESER HEIKE ,  BARG HEIKO ,  PTOCK ARNE ,  BRUCHMANN BERND ,  TUERK HOLGER

    Inventor： VOELKERT MARTIN ,  FEHR MARCUS ,  BRUESER HEIKE ,  BARG HEIKO ,  PTOCK ARNE ,  BRUCHMANN BERND ,  TUERK HOLGER

    IPC: A61Q5/00 ,  A61K8/64 ,  A61Q3/00 ,  C07D207/448 ,  C07K14/435

    CPC classification number: C07K14/47 ,  A61K8/64 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/10 ,  C07D207/448

    Abstract: Disclosed are keratin-binding polypeptide agents in the form of conjugates (A'B'C') or (A'B'C'D') comprising (A') a polypeptide sequence derived from a keratin-binding polypeptide (A), and (B') a statistical average of at least one polymer chain derived from a water-soluble or water-dispersible polymer (B) that carries lateral and/or terminal reactive functional groups (b1) and is selected in such a way as to form a homogeneous aqueous solution or dispersion along with the keratin-forming polypeptide (A) to be reacted to form the conjugate (A'B'C') or (A'B'C'D') in standard conditions, the polypeptide (A) in said aqueous solution or dispersion still having a keratin-binding activity. (C') At least one linker group links the polymer chain (B') to the polypeptide sequence (A'), and (D') optionally, a statistical average of at least one effector group is linked to the polymer chain (B'). Also disclosed are a method for the production of said active polypeptide substances and the use thereof for modifying keratin and keratin-containing materials and producing cosmetic and pharmaceutical compositions.

    Abstract translation: 角蛋白多肽偶联物的形式（A'B'C“）或（A'B'C'D”），其包含（A“）从角蛋白结合多肽（A）衍生的多肽序列，（B”）在随机 指至少一个聚合物链，从水溶性或水分散性，侧链和/或末端反应性官能团（b1）的（B）带有聚合物衍生的，其是根据其与偶联物一起选择（A'B'C） 或（A'B'C'D“）要反应角蛋白的结合多肽的（a）在正常状态下，均匀的水溶液或分散体，其中所述多肽（a）中仍然有角蛋白的结合活性，所述（C”）的至少一个连接基团 具有多肽序列（A'）的聚合物链（B'）连接并且其中（D'）任选地在统计平均值上与聚合物链（B'）的至少一个效应子基团结合; 它们的制备方法及其用于改性含角蛋白和角蛋白的材料以及用于生产化妆品和药物组合物的用途。

    8.
    发明专利
    未知

    公开(公告)号：DE502005006284D1

    公开(公告)日：2009-01-29

    申请号：DE502005006284

    申请日：2005-05-24

    Applicant: BASF SE

    Inventor： BARG HEIKO ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  PTOCK ARNE

    IPC: A61K8/64 ,  A61Q1/02 ,  A61Q3/00 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/04 ,  A61Q19/10 ,  C07K14/47

    Abstract: The invention relates to novel keratin-binding protein active substances, and also to the production and use thereof. Particularly suitable keratin-binding polypeptides are sequences which are contained in human desmoplakin or are derived therefrom by altering the human desmoplakin polypeptide sequences such as amino acid insertions, substitutions or deletions. The polypeptide sequences of the human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID NO: 1, position 2193 2481, in addition to functional equivalents thereof. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 2871 and the functional equivalents thereof.

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