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公开(公告)号：JP2011147801A
公开(公告)日：2011-08-04
申请号：JP2011061244
申请日：2011-03-18
Inventor： ATTERBURY WILLIAM G , BOUTON CHAD E , BUSICK DAVID R , DVORSKY JAMES E , GAYDOS PETER A , HOLLEY DAVID A , MEEK DANIEL D , TREES GREGORY A
CPC classification number: A61M15/02 , A61M11/001 , B05B1/18 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/1691
Abstract: PROBLEM TO BE SOLVED: To provide an EHD nozzle suitable for use in a portable pulmonary aerosol delivery device. SOLUTION: The improved Electrohydrodynamic (EHD) nozzle 20a particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes 26. Some versions further eliminate wetting while enhancing neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip 32 allows horizontal dispensing, and using dielectric nozzle tips 32 with low surface energy allows to avoid wicking between dispenses and advantageously reduce achievable particle size when dispensing. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供适用于便携式肺部气溶胶输送装置的EHD喷嘴。 解决方案：特别适合于手持式肺部气溶胶吸入器的改进的电动力学（EHD）喷嘴20a通过减少或消除放电电极26的屏蔽而减少或消除润湿来增加治疗液体的一致和有效的分配。一些形式进一步消除润湿同时增强中和 的气溶胶通过呈现离子的电晕风环绕环绕气溶胶。 将具有一致的压降的改进的液体分布结合到每个EHD喷嘴尖端32允许水平分配，并且使用具有低表面能的电介质喷嘴尖端32允许避免分配之间的芯吸，并且有利地减少分配时可实现的粒度。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：WO0038770A3
公开(公告)日：2001-08-02
申请号：PCT/US9930675
申请日：1999-12-22
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： ZIMLICH WILLIAM C JR , DVORSKY JAMES E , BUSICK DAVID R , PETERS RICHARD D
IPC: A61M11/00 , A01G23/10 , A61M15/00 , A61M15/02 , A62C13/62 , A62C13/66 , A62C35/58 , B05B5/00 , B05B5/025 , B05B5/16
CPC classification number: B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
Abstract: A device (10) and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device (10) includes a housing (12) of such size that it can be held in a user's one hand with an exit opening (14) in the housing (12) for directing the aerosol to the user's mouth. The housing (12) encloses a dispensing system (20) for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus (30) and an electrohydrodynamic apparatus (30) for aerosolizing the liquid and delivering the aerosol to the exit opening (14). The electrohydrodynamic apparatus (30) produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites (34) each having a tip end, the spray sites (34) cooperating with a charge source to result in an aerosolized spray from at least one tip end (48), a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes (36) downstream of the plurality of discharge electrodes (38).
Abstract translation: 一种用于将具有治疗特性的雾化液体输送到使用者肺部的装置（10）和方法。 紧凑和方便的装置（10）包括一个壳体（12），其尺寸使得它可以用一只手保持在壳体（12）中的出口（14），用于将气雾剂引导到使用者的嘴中。 壳体（12）包围分配系统（20），用于容纳待雾化的液体并将其输送到电流体动力学设备（30）和电流体动力学设备（30），以用于雾化液体并将气雾剂输送到出口开口（14 ）。 电流体动力学设备（30）产生具有单分散可呼吸液滴尺寸和接近零速度的雾化液滴。 该雾化设备包括多个喷射部位（34），每个喷射部位具有尖端，喷射部位（34）与充电源配合以导致来自至少一个尖端（48）的雾化喷射，多个放电电极 在所述尖端的下游，以及所述多个放电电极（38）下游的多个参考电极（36）。
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公开(公告)号：AU2005284706B2
公开(公告)日：2011-02-24
申请号：AU2005284706
申请日：2005-09-14
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： DVORSKY JAMES E , WILSON MARK R , ALAVATTAM SREEDHARA , PIATT BEVERLY A , FOUNTAIN WILLIAM M IV , COWAN ADA S
Abstract: A non-respirable aerosol, particularly a non-respirable aerosol comprising a biologically-effective amount of a biologically-active agent dissolved, emulsified, or suspended in a highly-aqueous liquid carrier vehicle. The highly-aqueous liquid carrier vehicle comprises about 60 wt % to about 100 wt % water, about 0 wt % to about 40 wt % of a co-solvent, about 0.05 wt % to about 10 wt % of an acceptable surfactant, and about 0 wt % to about 10 wt % of an excipient. The non-respirable aerosol is substantially monodisperse when dispensed from a sprayhead assembly comprising a preferably linear array of a plurality of nozzles and at least one counter electrode adapted to substantially equalize the charge fields of the plurality of nozzles.
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公开(公告)号：AU2004218486B2
公开(公告)日：2010-04-22
申请号：AU2004218486
申请日：2004-02-26
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： DVORSKY JAMES E , HOLLEY DAVID A , BUSICK DAVID R , GAYDOS PETER A , ATTERBURY WILLIAM G , MEEK DANIEL D , TREES GREGORY A , BOUTON CHAD E
Abstract: An improved Electrohydrodynamic (EHD) nozzle particularly suitable for a handheld pulmonary aerosol inhaler increases the consistent and efficient dispensing of therapeutic liquids by reducing or eliminating wetting through shielding of discharge electrodes. Some versions further eliminate wetting while enhances neutralization of the aerosol through presentation of a corona wind of ions annularly surround the aerosol. Incorporation of improved liquid distribution with consistent pressure drops to each EHD nozzle tip allows horizontal dispensing, and by using dielectric nozzle tips with low surface energy to thereby avoid wicking between dispenses and to advantageously reduce achievable particle size when dispensing. Some versions feature enhanced snap-fit assembly and other manufacturability advantages. One of the unique features of the EHD nozzles is achieved high dose rate (microliters/minute) with low wetting and small particle size (1.0-5 microns), although these properties tend to be mutually exclusive. Furthermore, these attributes are incorporated into a conveniently small, handheld device.
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公开(公告)号：ZA200108590B
公开(公告)日：2003-09-05
申请号：ZA200108590
申请日：2001-10-18
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： BUSICK DAVID R , DVORSKY JAMES E , TREES GREGORY A , SAUNDERS JAMES H
IPC: A61M20060101 , B05B20060101 , B05B , A61M
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Patent Agency Ranking
公开(公告)号：AU764814B2
公开(公告)日：2003-08-28
申请号：AU2592900
申请日：1999-12-22
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： ZIMLICH WILLIAM C , DVORSKY JAMES E , BUSICK DAVID R , PETERS RICHARD D
IPC: A61M11/00 , A01G23/10 , A61M15/00 , A61M15/02 , A62C13/62 , A62C13/66 , A62C35/58 , B05B5/00 , B05B5/025 , B05B5/16
Abstract: A device and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device includes a housing of such size that it can be held in a user's one hand with an exit opening in the housing for directing the aerosol to the user's mouth. The housing encloses a dispensing system for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus and an electrohydrodynamic apparatus for aerosolizing the liquid and delivering the aerosol to the exit opening. The electrohydrodynamic apparatus produces a cloud of aerosolized liquid droplets having a monodispersed reparable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites each having a tip end, the spray sites cooperating with a charge source to result in an aerosolized spray from at least one tip end, a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes downstream of the plurality of discharge electrodes.
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公开(公告)号：BR0009992A
公开(公告)日：2002-01-08
申请号：BR0009992
申请日：2000-04-20
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： BUSICK DAVID R , DVORSKY JAMES E , TREES GREGORY A , SAUNDERS JAMES H
Abstract: A electrohydrodynamic aerosol sprayer wherein a gas flow deflector is used for creating a gas flow past the spray nozzle to stabilize the Taylor cone and to transport at least a portion of the aerosol away from the region downstream of the spray nozzle. This stabilization of the cone and transport of aerosol improves the droplet size and distribution and may also reduce the deposit of droplets on the internal components of the device.
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公开(公告)号：CA2656526A1
公开(公告)日：2008-01-03
申请号：CA2656526
申请日：2007-06-26
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： LIND JAMES J , SCHULTE STEPHEN , DVORSKY JAMES E , MOWRER MATTHEW
Abstract: This invention pertains to the control of high voltage power, and in part icular to control of high voltage power from low voltage sources while reduc ing unwanted self resonance in the windings of a self oscillating flyback co nverter.
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公开(公告)号：AU2005284706A1
公开(公告)日：2006-03-23
申请号：AU2005284706
申请日：2005-09-14
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： DVORSKY JAMES E , WILSON MARK R , ALAVATTAM SREEDHARA , PIATT BEVERLY A , FOUNTAIN WILLIAM M IV , COWAN ADA S
Abstract: A non-respirable aerosol, particularly a non-respirable aerosol comprising a biologically-effective amount of a biologically-active agent dissolved, emulsified, or suspended in a highly-aqueous liquid carrier vehicle. The highly-aqueous liquid carrier vehicle comprises about 60 wt % to about 100 wt % water, about 0 wt % to about 40 wt % of a co-solvent, about 0.05 wt % to about 10 wt % of an acceptable surfactant, and about 0 wt % to about 10 wt % of an excipient. The non-respirable aerosol is substantially monodisperse when dispensed from a sprayhead assembly comprising a preferably linear array of a plurality of nozzles and at least one counter electrode adapted to substantially equalize the charge fields of the plurality of nozzles.
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公开(公告)号：CA2418019A1
公开(公告)日：2002-02-14
申请号：CA2418019
申请日：2001-08-03
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： MILLETT STEPHEN M , DVORSKY JAMES E , TALBERT SHERWOOD G , GEORGE PAUL E II , PAUL DARRELL D , WIESMANN KLAUS H , HAUBERT THOMAS D , EVERS DAVID P , SCHELHORN JEAN E
Abstract: A thermal treatment system for supplying thermally conditioned or purified water for human or animal consumption, industrial processes, environmental containment, or removal of foreign species. The water purifier includes a he at exchanger for exchanging heat between outgoing thermally conditioned or purified water and incoming makeup water; a water heater is connected to the heat exchanger so as to receive pre-heated incoming makeup water, where the water heater subsequently heats the incoming preheated makeup water to a set - point temperature in the case of thermally conditioned water and for purifie d water also holds the water for a period of time sufficient to inactivate selected organisms to a predetermined level. The heat exchanger has one or more treated water outlets for supplying thermally conditioned or purified water at slected temperatures.
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