公开(公告)号：WO2002102772A1

公开(公告)日：2002-12-27

申请号：PCT/US2002/019372

申请日：2002-06-17

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： WERPY, Todd ,  FRYE, John, G., Jr. ,  WANG, Yong ,  ZACHER, Alan, H.

IPC: C07D207/26

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.

Abstract translation: 本发明提供了通过氢化制备N-甲基吡咯烷和类似化合物的方法。 还描述了用于该方法的新型催化剂和新的条件/收率。 其他工艺改进可以包括提取和水解步骤。 一些优选的反应发生在水相中。 用于制备N-甲基吡咯烷的原料可包括琥珀酸，N-甲基琥珀酰亚胺及其类似物。

公开(公告)号：EP1412329A1

公开(公告)日：2004-04-28

申请号：EP02756233.9

申请日：2002-06-17

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： WERPY, Todd ,  FRYE, John, G., Jr. ,  WANG, Yong ,  ZACHER, Alan, H.

IPC: C07D207/26

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.