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公开(公告)号：AU2013215237A1
公开(公告)日：2014-07-24
申请号：AU2013215237
申请日：2013-01-30
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： DOCKAL MICHAEL , SCHEIFLINGER FRITZ , KNAPPE SABINE , TILL SUSANNE , HAI TON , SANDERS PAUL , DANDE PRASAD , JIANG CONG
IPC: A61K31/715 , A61P7/04
Abstract: The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting
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公开(公告)号：NZ591045A
公开(公告)日：2013-01-25
申请号：NZ59104509
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SANDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
Abstract: Disclosed is a compound of Formula I e.g. 4-(((2,5-dioxopyrrolidin-1-yloxy)carbonyloxy )methyl)phenyl 4-(2-methoxypolyethoxy)-2-methylbutanoate wherein the substituents are defined in the specification.
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公开(公告)号：ES2902773T3
公开(公告)日：2022-03-29
申请号：ES18815376
申请日：2018-10-31
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： BARRY JOHN , SANDERS PAUL , SINGH RAHUL , PARMAR KRISHNAKUMARSINH H , KO BEN , KLUNK STEPHANIE
Abstract: Un sistema de administración que comprende: (i) una jeringa, la jeringa que incluye un émbolo y un barril, el émbolo configurado para acoplarse y trasladarse a lo largo de una superficie interior del barril; (ii) una sustancia en polvo que se va a administrar, la sustancia en polvo colocada dentro del barril de la jeringa; y (iii) un dispositivo de administración que comprende: un anillo de retención; una tapa; y un muelle, colocado entre el anillo de retención y la tapa, el anillo de retención y la tapa estructurados para capturar extremos opuestos del muelle de modo que el muelle se retiene por el anillo de retención y la tapa, y la tapa, muelle y anillo de retención forman un montaje integral, donde el muelle es un muelle de compresión, de modo que el muelle desvía la tapa lejos del anillo de retención; donde la tapa incluye: una clavija, la clavija configurada para extenderse en y acoplarse a un émbolo de una jeringa, donde la clavija se extiende a lo largo de un eje del muelle hacia el anillo de retención y se coloca de manera concéntrica dentro del muelle, y donde un extremo proximal del émbolo define un receptáculo ubicado y arreglado para recibir y acoplarse a la clavija, y una pluralidad de brazos de pestillo, la pluralidad de brazos de pestillo configurados para extenderse desde una superficie interior de la tapa, donde un extremo de cada uno de la pluralidad de brazos de pestillo incluye una superficie de leva inclinada y un resalto de pestillo, el resalto de pestillo que define una superficie de pestillo opuesta a la superficie interior de la tapa, donde la tapa incluye además una superficie escalonada elevada que sobresale desde la superficie interior de la tapa para bloquear de manera cooperativa un extremo con reborde del émbolo entre la superficie de pestillo y la superficie escalonada elevada; donde el anillo de retención y la tapa incluyen cada uno una pluralidad de clips que se extienden hacia dentro ubicados y arreglados para capturar uno de los extremos opuestos del muelle; donde el dispositivo de administración se puede mover entre: una posición comprimida, donde la tapa se mueve hacia el anillo de retención y el muelle se comprime, trasladando de este modo el émbolo hacia un extremo distal de la jeringa, y una posición relajada, donde la tapa se mueve lejos del anillo de retención y el muelle se relaja, trasladando de este modo el émbolo hacia un extremo proximal de la jeringa .
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公开(公告)号：SG11202003797VA
公开(公告)日：2020-05-28
申请号：SG11202003797V
申请日：2018-10-31
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： BARRY JOHN , SANDERS PAUL , SINGH RAHUL , PARMAR KRISHNAKUMARSINH H , KO BEN , KLUNK STEPHANIE
Abstract: Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.
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公开(公告)号：AU2018358223A1
公开(公告)日：2020-05-07
申请号：AU2018358223
申请日：2018-10-31
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： BARRY JOHN , SANDERS PAUL , SINGH RAHUL , PARMAR KRISHNAKUMARSINH H , KO BEN , KLUNK STEPHANIE
Abstract: Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.
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Patent Agency Ranking
公开(公告)号：CA2968104A1
公开(公告)日：2016-06-23
申请号：CA2968104
申请日：2015-12-18
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： SANDERS PAUL , FULGHUM TIMOTHY MICHAEL , BARRY JOHN J
IPC: A61K31/718 , A61L26/00 , A61P7/04 , A61P17/02 , A61P41/00
Abstract: The present disclosure relates, in general, to hemostatic compositions comprising polysaccharide based polymers, such as amylopectins, amylose, dextrins, maltodextrins and icodextrin and modified forms thereof, cross-linked with a cross-linking agent that are useful as a hemostatic composition. Also provided are methods of treating injury and slowing or stopping bleeding using a hemostatic composition disclosed herein.
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公开(公告)号：CA2793493A1
公开(公告)日：2011-10-20
申请号：CA2793493
申请日：2011-04-08
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： BUI TUAN , HAI TON THAT , NORDHAUS MARK , SANDERS PAUL , JIANG CONG , LAMB DAVID , YARDIMCI OZLEM
Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.
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公开(公告)号：CA3076826A1
公开(公告)日：2019-05-09
申请号：CA3076826
申请日：2018-10-31
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： BARRY JOHN , SANDERS PAUL , SINGH RAHUL , PARMAR KRISHNAKUMARSINH H , KO BEN , KLUNK STEPHANIE
Abstract: Polymeric compositions, methods, and delivery devices for inhibiting bleeding are disclosed. The method includes applying a dried material topically to a wound site, where the material may include a cross-linked biologically compatible polymer which forms a hydrogel when exposed to blood and where the material may not include an active agent such as thrombin. A spring-loaded delivery device as described herein may be used to apply the dried material.
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公开(公告)号：CA2731184C
公开(公告)日：2017-03-21
申请号：CA2731184
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SANDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
IPC: C07C69/708 , A61P7/00 , C07C69/63 , C08G65/333
Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described. Examples of drug conjugates described include conjugates of Formula II: (see formula II)
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公开(公告)号：BRPI0917819A2
公开(公告)日：2015-11-24
申请号：BRPI0917819
申请日：2009-08-21
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： AMBROISE AROUNAGUIRY , MELNICK BENNETT , QUINN CATHERINE , JIANG CONG , YANG GUOHAN , LI JIE , BROWN LARRY R , SANDERS PAUL , HAI TON THAT
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