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公开(公告)号：WO2013060769A3
公开(公告)日：2013-06-20
申请号：PCT/EP2012071135
申请日：2012-10-25
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： SANDERS PAUL J , DANDE PRASAD , NORDHAUS MARK A , DONOVAN SHANE
CPC classification number: C07K14/78 , A61L24/001 , A61L24/104 , A61L26/0038 , A61L26/0061 , A61L2400/04
Abstract: The invention discloses a method for producing a hemostatic composition comprising mixing a biocompatible polymer suitable for use in hemostasis and a genipin-type crosslinker, crosslinking said polymer by said genipin-type crosslinker to obtain a crosslinked biocompatible polymer, and finishing said crosslinked polymer to a pharmaceutically acceptable hemostatic composition, new hemostatic compositions and methods for using such compositions.
Abstract translation: 本发明公开了一种生产止血组合物的方法，该方法包括混合适用于止血的生物相容性聚合物和京尼平型交联剂，通过所述京尼平型交联剂交联所述聚合物以获得交联的生物相容性聚合物，并且将所述交联聚合物整理为 药学上可接受的止血组合物，新的止血组合物和使用这种组合物的方法。
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公开(公告)号：AU2013215237A1
公开(公告)日：2014-07-24
申请号：AU2013215237
申请日：2013-01-30
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： DOCKAL MICHAEL , SCHEIFLINGER FRITZ , KNAPPE SABINE , TILL SUSANNE , HAI TON , SANDERS PAUL , DANDE PRASAD , JIANG CONG
IPC: A61K31/715 , A61P7/04
Abstract: The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting
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公开(公告)号：CA2861077A1
公开(公告)日：2013-08-08
申请号：CA2861077
申请日：2013-01-30
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： DOCKAL MICHAEL , SCHEIFLINGER FRITZ , KNAPPE SABINE , TILL SUSANNE , HAI TON , SANDERS PAUL , DANDE PRASAD , JIANG CONG
IPC: A61K31/715 , A61P7/04
Abstract: The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting in vivo as therapeutic and prophylactic agents and in vitro as an aid to studies of the blood clotting process.
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