公开(公告)号：MY132474A

公开(公告)日：2007-10-31

申请号：MYPI19972614

申请日：1997-06-12

Applicant: BAXTER INT

Inventor： NORMA J OFSTHUN ,  PAUL J SOLTYS ,  GRETCHEN A KUNAS

IPC: B01D63/02 ,  A61M1/34 ,  A61M1/36 ,  B01D61/00 ,  B01D67/00 ,  B01D69/14 ,  B01J20/28 ,  B01J20/32

Abstract: THE PRESENT INVENTION PROVIDES AN IMPROVED AFFINITY MEMBRANE DEVICE AND METHOD FOR THE EFFECTIVE REMOVAL OF TARGET MOLECULES IN PLASMA. THE AFFINITY MEMBRANE DEVICE IS DESIGNED FOR USE IN AN EXTRACORPOREAL BLOOD CIRCUIT AND CAN BE EMPLOYED CONCURENTLY WITH OTHER THERAPEUTIC PROCESSES FOR THE PURIFICATION OF BLOOD. THE DEVICE OF THE PRESENT INVENTION CONSISTS OF HOLLOW FIBER MEMBRANES HAVING SPECIFIED DIMENSIONS AND TRANSFER PROPERTIES, LIGAND IMMOBILIZED TO THE PORE SURFACE OF THE HOLLOW FIBERS AND ALLOW APPROPRIATE ENTRY AND EXIT OF THE BLOOD. IN A PREFERRED EMBODIMENT, SPECIFIC IMMOBILIZATION CHEMISTRIES ARE UTILIZED TO ATTACH THE LIGANDS TO THE HOLLOW FIBERS FOR OPTIMAL FUNCTION.