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公开(公告)号：AU4046300A
公开(公告)日：2000-10-23
申请号：AU4046300
申请日：2000-03-29
Applicant: BAXTER INT
Inventor： PEJAVER SATISH K , MOTHERAM RAJESHWAR , RABINOW BARRETT E , ROSA JOSBEN C DELA
Abstract: Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduces the chances of fat overload when administered over an extended period of time to chronically ill patients.
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公开(公告)号：AU774259B2
公开(公告)日：2004-06-24
申请号：AU4046300
申请日：2000-03-29
Applicant: BAXTER INT
Inventor： PEJAVER SATISH K , MOTHERAM RAJESHWAR , RABINOW BARRETT E , ROSA JOSBEN C DELA
Abstract: Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduces the chances of fat overload when administered over an extended period of time to chronically ill patients.
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公开(公告)号：BR0009541A
公开(公告)日：2002-01-02
申请号：BR0009541
申请日：2000-03-29
Applicant: BAXTER INT
Inventor： PEJAVER SATISH K , MOTHERAM RAJESHWAR , RABINOW BARRETT E , ROSA JOSBEN C DELA
Abstract: Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduces the chances of fat overload when administered over an extended period of time to chronically ill patients.
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