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1.发明申请MELT-SPUN POLYSULFONE SEMIPERMEABLE MEMBRANES AND METHODS FOR MAKING THE SAME 审中-公开MELT-SPUN POLYSULFONE可切割膜及其制造方法
公开(公告)号：WO2004058385A9
公开(公告)日：2004-11-25
申请号：PCT/US0340499
申请日：2003-12-18
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： HAN WENLI , KETTERER MARTIN , LEE JONNIE , NGUYEN THANH , WASHINGTON GEORGE , JORDAN DELORES , DE DIBYENDU
CPC classification number: B01D71/68 , A61M1/16 , B01D67/0011 , B01D67/002 , B01D67/0027 , B01D67/003 , B01D69/02 , B01D69/08 , B01D69/087 , B01D2325/34 , B01D2325/36 , C08J3/091 , C08J2381/06
Abstract: The present invention provides, inter alia, a composition useful for producing a homogeneous, semipermeable membrane, the composition comprising a polysulfone semipermeable membrane, the polysulfone semipermeable membrane comprising a mixture of: an ultra-high-molecular-weight hydrophilic polymer, a polysulfone compound and a solvent for the polysulfone compound, and the polysulfone semipermeable membrane having a homogeneous structure such that the polysulfone semipermeable membrane has a substantially uniform structure. Another aspect of this invention discloses methods for fabricating semipermeable membranes by homogeneously mixing the composition, melting the composition, and melt-spinning the molten composition. Another aspect of the present invention includes homogeneous, melt-spun, semipermeable membranes useful for liquid separation processes, such as, but not limited to, microfiltration, ultrafiltration, dialysis, and reverse osmosis.
Abstract translation: 本发明尤其提供了一种用于制备均匀的半透膜的组合物，该组合物包含聚砜半透膜，聚砜半透膜包含以下混合物：超高分子量亲水聚合物，聚砜化合物 和聚砜化合物的溶剂，聚砜半透膜具有均匀的结构，使得聚砜半透膜具有基本均匀的结构。 本发明的另一方面公开了通过均匀混合组合物，熔融组合物和熔融组合物熔融纺制制造半透膜的方法。 本发明的另一方面包括用于液体分离过程的均匀的熔纺的半透膜，例如但不限于微滤，超滤，透析和反渗透。
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Patent Agency Ranking
公开(公告)号：CA2511116A1
公开(公告)日：2004-07-15
申请号：CA2511116
申请日：2003-12-18
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： HAN WENLI , LEE JONNIE , NGUYEN THANH , KETTERER MARTIN , JORDAN DELORES , WASHINGTON GEORGE , DE DIBYENDU
Abstract: The present invention provides, inter alia, a composition useful for produci ng a homogeneous, semipermeable membrane, the composition comprising a polysulfone semipermeable membrane, the polysulfone semipermeable membrane comprising a mixture of: an ultra-high-molecular-weight hydrophilic polymer, a polysulfone compound and a solvent for the polysulfone compound, and the polysulfone semipermeable membrane having a homogeneous structure such that the polysulfone semipermeable membrane has a substantially uniform structure . Another aspect of this invention discloses methods for fabricating semipermeable membranes by homogeneously mixing the composition, melting the composition, and melt-spinning the molten composition. Another aspect of the present invention includes homogeneous, melt-spun, semipermeable membranes useful for liquid separation processes, such as, but not limited to, microfiltration, ultrafiltration, dialysis, and reverse osmosis.
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公开(公告)号：AU2003301102A1
公开(公告)日：2004-07-22
申请号：AU2003301102
申请日：2003-12-18
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： HAN WENLI , KETTERER MARTIN , LEE JONNIE , NGUYEN THANH , WASHINGTON GEORGE , JORDAN DELORES , DE DIBYENDU
Abstract: The present invention provides, inter alia, a composition useful for producing a homogeneous, semipermeable membrane, the composition comprising a polysulfone semipermeable membrane, the polysulfone semipermeable membrane comprising a mixture of: an ultra-high-molecular-weight hydrophilic polymer, a polysulfone compound and a solvent for the polysulfone compound, and the polysulfone semipermeable membrane having a homogeneous structure such that the polysulfone semipermeable membrane has a substantially uniform structure. Another aspect of this invention discloses methods for fabricating semipermeable membranes by homogeneously mixing the composition, melting the composition, and melt-spinning the molten composition. Another aspect of the present invention includes homogeneous, melt-spun, semipermeable membranes useful for liquid separation processes, such as, but not limited to, microfiltration, ultrafiltration, dialysis, and reverse osmosis.
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公开(公告)号：AU5724898A
公开(公告)日：1998-07-31
申请号：AU5724898
申请日：1997-12-30
Applicant: BAXTER INT
Inventor： NGUYEN THANH , JAANINE HAMID , RUZIUS KEES , CHIANG CHUNG-YUAN , MELUCH TIMOTHY B , SILVA LALITH K , RADOVICH JOHN M , WASHINGTON GEORGE
Abstract: The present invention discloses, inter alia, a composition useful for producing a homogeneous, semipermeable membrane, the composition comprising (1) a polysulfone compound, (2) a solvent, such as sulfolane, antypyrine, delta -valerolactam, diethyl phthalate, and mixtures thereof, and (3) a non-solvent, such as poly(ethylene glycol), di(ethylene glycol), tri(ethylene glycol), glycerol, and mixtures thereof. Another aspect of this invention discloses methods for fabricating semipermeable membranes by homogeneously mixing the composition of the polysulfone compound, solvent, and non-solvent, melting the composition, and melt-spinning the molten composition. Another aspect of the present invention includes homogeneous, melt-spun, semipermeable membranes useful for liquid separation processes, such as, but not limited to, microfiltration, ultrafiltration, dialysis, and reverse osmosis.
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公开(公告)号：AU5959196A
公开(公告)日：1996-12-18
申请号：AU5959196
申请日：1996-05-30
Applicant: BAXTER INT
Inventor： RADOVICH JOHN M , ROTHBERG MELVIN , WASHINGTON GEORGE
IPC: B01D39/18 , A61M1/16 , A61M1/18 , B01D63/02 , B01D65/00 , B01D65/02 , B01D67/00 , B01D69/02 , B01D69/08 , B01D71/16 , B29C67/20
Abstract: An improved process for making a cellulose acetate semipermeable mebrane and medical products therefrom. In the process there is provided a molten liquid comprising cellulose acetate, a solvent for cellulose acetate, and a non-solvent for cellulose acetate, and this liquid is extruded to produce the membrane as a sheet or a hollow fiber. The solvent and the non-solvent are removed from the extruded membrane to produce a semipermeable membrane having a water permeability, and this semipermeable membrane is then impregnated with a liquid consisting substantially of water so as to render the semipermeable membrane capable of being stored until time of use without undergoing a substantial loss in water permeability. The semipermeable membrane can be incorporated in a casing in order to produce a medical product, the membrane being impregnated in the product.
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公开(公告)号：AU5597894A
公开(公告)日：1994-06-08
申请号：AU5597894
申请日：1993-11-10
Applicant: BAXTER INT
Inventor： ALTHIN ANDERS , FERNANDEZ BEN , ELSEN RAYMOND , RUZIUS KEES , SILVA LALITH , WASHINGTON GEORGE
IPC: C08B30/04 , A61M1/16 , A61M1/18 , B01D39/18 , B01D63/02 , B01D65/00 , B01D65/02 , B01D67/00 , B01D69/02 , B01D69/08 , B01D71/16
Abstract: Semipermeable membranes are disclosed for purifying aqueous biological fluids. The membranes are particularly suitable for purifying extracorporeal blood via hemodialysis. The membranes, preferably configured as hollow fibers, are made from a hydrophilic polymeric material, preferably cellulose acetate. Features of the membranes include an ultrafiltration coefficient (KuF) of about 15 to about 55 mL/hr/mmHg/m (thus termed "high-flux" type membranes), a urea mass transfer coefficient (KoV(urea)) of at least 38x10 cm/min, and a ratio of KoV(urea)/KuF of at least 2.5x10 . Hollow fibers of such membranes suitable for hemodialysis have a lumen diameter of about 175 to about 210 mu m and a wall thickness of about 10 to about 35 mu m. According to disclosed methods for making the membranes, a melt comprising about 32 to about 40% w/w cellulose acetate, about 5 to about 10% w/w glycerine, and about 50 to about 67% w/w polyethylene glycol is extruded to make hollow fibers; the fibers are cooled, cold-stretched, water-leached, and replasticized using a glycerine solution.
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