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公开(公告)号:DE69421689T2
公开(公告)日:2000-06-29
申请号:DE69421689
申请日:1994-09-20
Applicant: BAXTER INT
Inventor: THOMPSON STACEY , MCSHANE JAMES , WONG JOSEPH , WOOD RAY
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公开(公告)号:DE69421689D1
公开(公告)日:1999-12-23
申请号:DE69421689
申请日:1994-09-20
Applicant: BAXTER INT
Inventor: THOMPSON STACEY , MCSHANE JAMES , WONG JOSEPH , WOOD RAY
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公开(公告)号:DE69323295D1
公开(公告)日:1999-03-11
申请号:DE69323295
申请日:1993-11-03
Applicant: BAXTER INT
Inventor: WOOD RAY , HANSEN LEE , CRAWFORD JOHN
Abstract: A method of determining the critical vapor pressure of a hygroscopic material, such as a drug. A drug sample is placed in a substantially isothermal environment. A vapor, such as water vapor, at a given pressure is then placed in the ambient air over the drug. The rate of heat production from this sample at the given water vapor pressure, or the humidity of the air above the sample, is then measured. The water vapor pressure over the drug is gradually increased. Simultaneously, the rate of increase in heat production from the drug sample, or the rate of change of the relative humidity of the air above the drug sample, is measured. A marked increase in the rate of heat production generated by the drug, or a marked change in the relative humidity of the air over the sample, signals the attainment of the critical water vapor pressure.
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公开(公告)号:DE69323729D1
公开(公告)日:1999-04-08
申请号:DE69323729
申请日:1993-10-04
Applicant: BAXTER INT
Inventor: WONG JOSEPH , WOOD RAY , MCSHANE JAMES
Abstract: A drug delivery device is provided for coupling a first container including a beneficial agent to a second member. In an embodiment, the device includes a substantially hollow member having a cannula mounted within a wall that divides the substantially hollow member into a first and second section. The first section includes means for receiving at least a portion of a first container. The substantially hollow member includes a wall that defines an exterior of the first section that is substantially flexible. A number of different cannula and flow path structures within the hollow member are possible pursuant to the present invention.
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公开(公告)号:DE69323729T2
公开(公告)日:1999-09-30
申请号:DE69323729
申请日:1993-10-04
Applicant: BAXTER INT
Inventor: WONG JOSEPH , WOOD RAY , MCSHANE JAMES
Abstract: A drug delivery device is provided for coupling a first container including a beneficial agent to a second member. In an embodiment, the device includes a substantially hollow member having a cannula mounted within a wall that divides the substantially hollow member into a first and second section. The first section includes means for receiving at least a portion of a first container. The substantially hollow member includes a wall that defines an exterior of the first section that is substantially flexible. A number of different cannula and flow path structures within the hollow member are possible pursuant to the present invention.
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公开(公告)号:DE69323295T2
公开(公告)日:1999-09-02
申请号:DE69323295
申请日:1993-11-03
Applicant: BAXTER INT
Inventor: WOOD RAY , HANSEN LEE , CRAWFORD JOHN
Abstract: A method of determining the critical vapor pressure of a hygroscopic material, such as a drug. A drug sample is placed in a substantially isothermal environment. A vapor, such as water vapor, at a given pressure is then placed in the ambient air over the drug. The rate of heat production from this sample at the given water vapor pressure, or the humidity of the air above the sample, is then measured. The water vapor pressure over the drug is gradually increased. Simultaneously, the rate of increase in heat production from the drug sample, or the rate of change of the relative humidity of the air above the drug sample, is measured. A marked increase in the rate of heat production generated by the drug, or a marked change in the relative humidity of the air over the sample, signals the attainment of the critical water vapor pressure.
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