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1.发明授权Clarification of blood serum and plasma using block copolymers of ethylene oxide and polyoxypropylene 失效使用环氧乙烷和聚氧丙烯的嵌段共聚物澄清血清和血浆
公开(公告)号：US3893991A
公开(公告)日：1975-07-08
申请号：US45669774
申请日：1974-04-01
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , PEETOOM FRANS
CPC classification number: A61K35/16 , Y10S530/83
Abstract: A method of clarifying blood serum and plasma to remove undesired proteinaceous and lipid particulate matter which comprises admixing the serum or plasma with from greater than about 20 to about 30% of block copolymers of ethylene oxide and polyoxypropylene polymer.
Abstract translation: 一种澄清血清和血浆以除去不想要的蛋白质和脂质颗粒物质的方法，其包括将血清或血浆与大于约20至约30％的环氧乙烷和聚氧丙烯聚合物的嵌段共聚物混合。
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2.发明授权Production of stable high-potency human ahf using polyethylene glycol and glycine to fractionate a cryoprecipitate of ahf concentrate 失效使用聚乙二醇和甘氨酸生产稳定的高磷酸性AHF以分解AHF浓缩物的酸性
公开(公告)号：US3631018A
公开(公告)日：1971-12-28
申请号：US3631018D
申请日：1970-05-01
Applicant: BAXTER LABORATORIES INC
Inventor： SHANBROM EDWARD , FEKETE LAJOS F
IPC: A23J1/06 , A61K38/00 , C07K14/755 , C07G7/00
CPC classification number: A23J1/06 , A61K38/00 , C07K14/755 , Y10S530/83
Abstract: THE PRODUCTION OF A STABLE ANTIHEMOPHILIC FACTOR OF HIGH POTENCY BY THE FRACTIONATION OF A CRYOPRECIPITATE CONCENTRATE OF ANTIHEMOPHILIC FACTOR.
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公开(公告)号：AU5584973A
公开(公告)日：1974-11-21
申请号：AU5584973
申请日：1973-05-17
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , HOLST STEPHEN L
IPC: A61K35/14 , A61K38/00 , A61K38/16 , C07K14/755 , C07G7/00
Abstract: Method for improving the performance of an anti-hemophilic factor obtained from blood plasma and plasma fractions, characterized in that it includes the addition of approximately 0.01 to 10 units of heparin, to said plasma or to said plasma fraction per ml. Of solution thereof. (Machine-translation by Google Translate, not legally binding)
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4.发明授权Clarification of blood serum and plasma using a block copolymer of ethylene oxide and polyoxypropylene 失效使用环氧乙烷和聚氧丙烯的嵌段共聚物澄清血清和血浆
公开(公告)号：US3893990A
公开(公告)日：1975-07-08
申请号：US45669874
申请日：1974-04-01
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , PEETOOM FRANK
CPC classification number: A61K35/16 , Y10S530/83
Abstract: A method of clarifying blood serum and plasma to remove undesired proteinaceous and lipid particulate matter which comprises admixing the serum or plasma with from greater than about 20 to about 30% of block copolymers of ethylene oxide and polyoxypropylene polymer.
Abstract translation: 一种澄清血清和血浆以除去不想要的蛋白质和脂质颗粒物质的方法，其包括将血清或血浆与大于约20至约30％的环氧乙烷和聚氧丙烯聚合物的嵌段共聚物混合。
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公开(公告)号：US3682881A
公开(公告)日：1972-08-08
申请号：US3682881D
申请日：1970-10-02
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , SHANBROM EDWARD
IPC: A61K38/00 , C07K14/755 , C12N9/74 , C07G7/00
CPC classification number: C12N9/6429 , A61K38/00 , C07K14/755 , C12Y304/21005 , Y10S530/83
Abstract: CONCENTRATES OF ANTIHEMIPHILIC FACTOR A AND PROTHROMBIN COMPLEX ARE PREPARED FROM CITRATED BLOOD PLASMA BY AN INITIAL FRACTIONATION WITH GLYCINE FOLLOWED BY MULTIPLE FRACTIONATIONS OF THE AHF-CONTAINING PRECIPITATE AND THE PROTROMBIN COMPLEX-CONTAINING SUPERNATE WITH POLYETHYLENE GLYCOL, THE AHF-CONTAINING FRACTION BEING GIVEN AN ADDITIONAL FRACTIONATION WITH GLYCINE AND THE PROTHROMBIN COMPLEX-CONTAINING FRACTION BEING GIVEN AN INTERMEDIATE ADSORPTION WITH TRIBASIC CALCIUM PHOSPHATE.
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Patent Agency Ranking6.发明授权
公开(公告)号：US3560475A
公开(公告)日：1971-02-02
申请号：US3560475D
申请日：1969-06-19
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , SHANBROM EDWARD
CPC classification number: C12N9/6429 , A61K38/00 , C12Y304/21005 , Y10S530/831
Abstract: A PROTHROMBIN COMPLEX PREPARED FROM A PLASMA FRACTION CONTAINING FACTORS II, VII, IX AND X BY ADSORPTION WITH TRIBASIC CALCIUM PHOSPHATE, ELUTION WITH TRISODIUM CITRATE, AND MULTIPLE PRECIPITATIONS WITH POLYETHYLENE GLYCOL.
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公开(公告)号：CA947655A
公开(公告)日：1974-05-21
申请号：CA52838
申请日：1969-05-28
Applicant: BAXTER LABORATORIES INC
Inventor： BISHOP ROBERT C , FEKETE LAJOS F , SHANBROM EDWARD
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公开(公告)号：DE2324717A1
公开(公告)日：1973-12-13
申请号：DE2324717
申请日：1973-05-16
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , HOLST STEPHEN L
IPC: A61K35/14 , A61K38/00 , A61K38/16 , C07K14/755 , A61K17/00
Abstract: Method for improving the performance of an anti-hemophilic factor obtained from blood plasma and plasma fractions, characterized in that it includes the addition of approximately 0.01 to 10 units of heparin, to said plasma or to said plasma fraction per ml. Of solution thereof. (Machine-translation by Google Translate, not legally binding)
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公开(公告)号：ATA433573A
公开(公告)日：1975-04-15
申请号：AT433573
申请日：1973-05-17
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , HOLST STEPHEN L
Abstract: Method for improving the performance of an anti-hemophilic factor obtained from blood plasma and plasma fractions, characterized in that it includes the addition of approximately 0.01 to 10 units of heparin, to said plasma or to said plasma fraction per ml. Of solution thereof. (Machine-translation by Google Translate, not legally binding)
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公开(公告)号：CA962591A
公开(公告)日：1975-02-11
申请号：CA124332
申请日：1971-10-04
Applicant: BAXTER LABORATORIES INC
Inventor： FEKETE LAJOS F , SHANBROM EDWARD
IPC: A61K38/00 , C07K14/755 , C12N9/74
Abstract: 1303408 Fractionating blood BAXTER LABORATORIES INC 4 Oct 1971 [2 Oct 1970] 46017/71 Heading A5B Glycine is added to citrated blood to produce antihaemophilic factor (AHF) as a precipitate and a plasma supernatent. The supernatent may be worked up by precipitation with polyethylene glycol (PEG) of M.W. c.200 to c.20000 and treatment with tricalcium phosphate to produce a prothrombin complex as shown in the diagram. The precipitate may also be treated as indicated with PEG and glycine to yield an AHF concentrate.
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