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    Preservation of organs
    2.
    发明授权
    Preservation of organs 失效
    保存器官

    公开(公告)号：US3892628A

    公开(公告)日：1975-07-01

    申请号：US31661272

    申请日：1972-12-19

    Applicant: BAXTER LABORATORIES INC

    Inventor： THORNE GALE H ,  WOOD ORIN LEW ,  KNUDSON KAY L

    IPC: A61M1/32 ,  C12K9/00

    CPC classification number: A61M1/32

    Abstract: Apparatus and method of preserving life organs, the apparatus having an organ container in which the organ may be subjected to elevated pressure, a pump pulsatilely delivering perfusate into the organ and an oxygenator to oxygenate the perfusate effluent from the organ. A constant pressure bias maintains a minimum pressure on the perfusate between pulses. A fluid flow control system delivers driving fluid in a pulsed manner to the pump at a selected rate and at selected pulse duration. The method includes delivering pulsed oxygenated perfusate to the organ and uniformly conducting perfusate away from the organ and providing a constant pressure bias on the perfusate. Loss or gain of liquid volume caused by waste secretion by the organ is compensated for.

    Abstract translation: 保存生命器官的装置和方法，所述装置具有器官可能受到升高的压力的器官容器，将脉冲地输送灌注液的泵送入器官，以及使来自器官的灌注液流出物的氧合器。 恒定压力偏压保持脉冲之间灌注液的最小压力。 流体流量控制系统以脉冲方式将驱动流体以选定的速率和选定的脉冲持续时间输送到泵。 该方法包括将脉冲氧化灌注液递送至器官并将器官均匀地导入灌注液并在灌注液上提供恒定的压力偏压。 由器官的废物分泌引起的液体体积的损失或增益得到补偿。

    PRESERVATION OF ORGANS
    3.
    发明专利
    PRESERVATION OF ORGANS 未知

    公开(公告)号：CA941701A

    公开(公告)日：1974-02-12

    申请号：CA94366

    申请日：1970-09-29

    Applicant: BAXTER LABORATORIES INC

    Inventor： THORNE GALE H ,  WOOD ORIN L ,  KNUDSON KAY L

    IPC: A01N1/00 ,  A61M1/32

    Abstract: 1314279 Organ perfusion apparatus BAXTER LABORATORIES INC 5 Oct 1970 [6 Oct 1969] 47190/70 Heading A2D An organ perfusion apparatus comprises a container for the organ, a circuit including the container for passing perfusate through the container, a pressure means for delivering the perfusate in a pulsatile manner to the container and means for maintaining between pressure pulses a pressure lower than the pressure on the perfusate in the container, oxygenating means in the circuit for oxygenating perfusate conducted from the organ and control means for determining the output of the pressure means, and including means for setting the period of each high pressure pulse. A suitable apparatus is shown in Fig. 1 wherein a pneumatic source 22 which preferably uses compressed oxygen communicates with a control unit 26 which pulses the oxygen and passes this gas to pump 40. Perfusate such as whole blood communicates with a simulated aorta 44 with each high pressure pulse through the line 38. Pressure of a preselected magnitude as determined by the control unit 26, exerts a biasing force upon the blood in the aorta. The blood then passes to a temperature bath 54 and thence to the organ in the container 38. This container may be of a transparent material to facilitate observation of the perfusion treatment. A accumulator 62 is connected to the organ to receive excreted products. The pulsed blood after circulation is carried to an oxygenator 66 to which fresh oxygen is communicated from control unit 26. The oxygenated blood is then passed to the simulated atruim 74 which communicates with the pump 40. To compensate for any reduction in blood volume in the system, there is provided a blood reservoir 78.

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