公开(公告)号：JPH1067743A

公开(公告)日：1998-03-10

申请号：JP22421497

申请日：1997-08-06

Applicant: BAYER AG

Inventor： STOLTEFUSS JUERGEN ,  BECHEM MARTIN ,  GROSS RAINER ,  HEBISCH SIEGBERT ,  SCHRAMM MATTHIAS

IPC: A61K31/435 ,  A61K31/44 ,  A61K31/443 ,  A61K31/445 ,  A61K31/451 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07C229/00 ,  C07C229/22 ,  C07C233/47 ,  C07C233/83 ,  C07C251/08 ,  C07C271/00 ,  C07C271/22 ,  C07C275/00 ,  C07C275/28 ,  C07C311/00 ,  C07C311/19 ,  C07C333/00 ,  C07C335/00 ,  C07D211/90 ,  C07D211/98 ,  C07D405/06 ,  C07D417/12 ,  C07D491/04 ,  C07D491/048 ,  C07F9/59

Abstract: PROBLEM TO BE SOLVED: To obtain a novel compound which is useful as a synthetic intermediate for a dihydropyridine derivative used in treatment of circulatory disorder and cardiovascular functional disorder. SOLUTION: This compound is represented by formula I [R is a (substituted) 1-12C alkyl, an alkenyl; Y is formula II (B is-NH; R is a 1-12C alkyl; R is H, a 1-12C alkyl; A is H, methyl);D is O, -NH; E is two H, =CHR (R is a 1-6C alkyl)], typically (1R,2S)-[ 1-methyl-2-methoxycarbonyl-2-(4-tolylsulfamoyl)] ethyl 1,4-dihydro-2,6-dimetyl-3-nitro-4-phenylpyridine-5-carboxylate. The compound of formula I is prepared by reaction of a compound of the formula: HO-Y with diketene of formula III.

公开(公告)号：WO9954326A8

公开(公告)日：1999-12-29

申请号：PCT/EP9902344

申请日：1999-04-07

Applicant: BAYER AG ,  STOLTEFUSS JUERGEN ,  GOLDMANN SIEGFRIED ,  KRAEMER THOMAS ,  SCHLEMMER KARL HEINZ ,  NIEWOEHNER ULRICH ,  PAESSENS ARNOLD ,  GRAEF ERWIN ,  LOTTMANN STEFAN ,  DERES KARL ,  WEBER OLAF ,  STOELTING JOERN

Inventor： STOLTEFUSS JUERGEN ,  GOLDMANN SIEGFRIED ,  KRAEMER THOMAS ,  SCHLEMMER KARL-HEINZ ,  NIEWOEHNER ULRICH ,  PAESSENS ARNOLD ,  GRAEF ERWIN ,  LOTTMANN STEFAN ,  DERES KARL ,  WEBER OLAF ,  STOELTING JOERN

IPC: C07D213/78 ,  A61K31/506 ,  A61P1/16 ,  A61P31/12 ,  C07D213/00 ,  C07D213/84 ,  C07D215/00 ,  C07D239/00 ,  C07D239/22 ,  C07D277/62 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14

CPC classification number: C07D239/22 ,  C07D213/78 ,  C07D213/84 ,  C07D401/04 ,  C07D401/14

Abstract: The invention relates to compounds of general formula (I) or general formula (Ia). The invention also relates to methods for producing said compounds of general formula (I) or (Ia) and to their use as medicaments, especially for treating and preventing hepatitis B.

Abstract translation: 本发明涉及通式（I）或（Ia）的化合物。 本发明还涉及用于制备式（I）或（Ia）和它们作为药物的用途，特别是对肝炎B的治疗和预防的化合物

公开(公告)号：WO0145712A8

公开(公告)日：2001-09-13

申请号：PCT/EP0012570

申请日：2000-12-12

Applicant: BAYER AG ,  PAESSENS ARNOLD ,  DERES KARL ,  WEBER OLAF ,  GRAEF ERWIN ,  GOLDMANN SIEGFRIED ,  KRAEMER THOMAS ,  NIEWOEHNER ULRICH ,  SCHLEMMER KARL HEINZ ,  STOLTEFUSS JUERGEN

Inventor： PAESSENS ARNOLD ,  DERES KARL ,  WEBER OLAF ,  GRAEF ERWIN ,  GOLDMANN SIEGFRIED ,  KRAEMER THOMAS ,  NIEWOEHNER ULRICH ,  SCHLEMMER KARL-HEINZ ,  STOLTEFUSS JUERGEN

IPC: A61K31/506 ,  A61K38/21 ,  A61P31/20

CPC classification number: A61K31/506 ,  A61K38/21 ,  A61K2300/00

Abstract: The invention relates to combinations of dihydropyrimidines, lamivudin and, optionally, interferon which inhibit the multiplication of HBV viruses, better than conventional agents.

Abstract translation: 二氢嘧啶，拉米夫定和任选的干扰素的组合比先前已知的方式更好地抑制HBV病毒的增殖。

公开(公告)号：WO0164652A9

公开(公告)日：2002-07-04

申请号：PCT/EP0101873

申请日：2001-02-20

Applicant: BAYER AG ,  BRAEUNLICH GABRIELE ,  LOEGERS MICHAEL ,  STOLTEFUSS JUERGEN ,  SCHMECK CARSTEN ,  NIELSCH ULRICH ,  STUERMER WERNER ,  GERDES CHRISTOPH ,  LUSTIG KLEMENS ,  SPERZEL MICHAEL

Inventor： BRAEUNLICH GABRIELE ,  LOEGERS MICHAEL ,  STOLTEFUSS JUERGEN ,  SCHMECK CARSTEN ,  NIELSCH ULRICH ,  STUERMER WERNER ,  GERDES CHRISTOPH ,  LUSTIG KLEMENS ,  SPERZEL MICHAEL

IPC: A61P7/06 ,  C07D237/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/50

CPC classification number: C07D401/12 ,  C07D237/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention relates to the field of erythropoiesis and, in particular, relates to 5-methyldihydropyridazinones of general formula (I) and to the use thereof as medicaments, preferably for the prophylaxis of and/or for combating anemias.

Abstract translation: 本发明涉及红细胞生成的领域。 特别地，5-Methyldihydropyridazinone通式（I）和它们作为药物的用途，优选用于所描述的预防和/或防治贫血。

公开(公告)号：WO0045894A2

公开(公告)日：2000-08-10

申请号：PCT/EP0000519

申请日：2000-01-24

Applicant: BAYER AG ,  STOLTEFUSS JUERGEN ,  BRAEUNLICH GABRIELE ,  HINZEN BERTHOLD ,  KRAEMER THOMAS ,  PERNERSTORFER JOSEF ,  STUEDEMANN THOMAS ,  NIELSCH ULRICH ,  BECHEM MARTIN ,  LOHRMANN EMANUEL ,  GERDES CHRISTOPH ,  SPERZEL MICHAEL ,  LUSTIG KLEMENS ,  MAYR LORENZ

Inventor： STOLTEFUSS JUERGEN ,  BRAEUNLICH GABRIELE ,  HINZEN BERTHOLD ,  KRAEMER THOMAS ,  PERNERSTORFER JOSEF ,  STUEDEMANN THOMAS ,  NIELSCH ULRICH ,  BECHEM MARTIN ,  LOHRMANN EMANUEL ,  GERDES CHRISTOPH ,  SPERZEL MICHAEL ,  LUSTIG KLEMENS ,  MAYR LORENZ

IPC: A61K31/415 ,  A61K31/4155 ,  A61K31/4439 ,  A61P7/06 ,  C07D231/12 ,  C07D401/04 ,  C07D409/04 ,  A61P

CPC classification number: C07D231/12 ,  A61K31/415 ,  C07D401/04 ,  C07D409/04

Abstract: The present invention relates to novel and known pyrazole carboxamides of general formulae (I and Ia). The invention also relates to the production of pyrazole carboxamides by means of solid phase chemistry or novel pyrazole carboxamides. The pyrazole carboxamides are used as medicaments, especially medicaments for the treatment of anaemias.

Abstract translation: 本发明涉及新的和已知Pyrazolcarbonsäureamide通式（I）和（Ia）。 此外，生产Pyrazolcarbonsäureamide的任一固相化学或新的吡唑进行说明。 该Pyrazolcarbonsäureamide是，尤其是pecial作为药物使用的药物用于治疗贫血。

公开(公告)号：WO03000269A3

公开(公告)日：2003-04-03

申请号：PCT/EP0206309

申请日：2002-06-10

Applicant: BAYER AG ,  NIEWOEHNER ULRICH ,  ERGUEDEN JENS-KERIM ,  BAUSER MARCUS ,  BURKHARDT NILS ,  FLUBACHER DIETMAR ,  FRIEDL ARNO ,  GERLACH IRENE ,  HINZ VOLKER ,  JORK REINHARD ,  NAAB PAUL ,  REPP THORSTEN-OLIVER ,  SCHLEMMER KARL-HEINZ ,  STOLTEFUSS JUERGEN

Inventor： NIEWOEHNER ULRICH ,  ERGUEDEN JENS-KERIM ,  BAUSER MARCUS ,  BURKHARDT NILS ,  FLUBACHER DIETMAR ,  FRIEDL ARNO ,  GERLACH IRENE ,  HINZ VOLKER ,  JORK REINHARD ,  NAAB PAUL ,  REPP THORSTEN-OLIVER ,  SCHLEMMER KARL-HEINZ ,  STOLTEFUSS JUERGEN

IPC: A61K31/00 ,  A61K31/53 ,  A61P25/16 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61K31/00 ,  A61K31/53 ,  F17C2201/0119 ,  F17C2201/058 ,  F17C2203/0617 ,  F17C2203/0636 ,  F17C2205/0314 ,  F17C2209/221 ,  F17C2209/228 ,  F17C2223/0123 ,  F17C2260/021 ,  F17C2270/0181

Abstract: The invention relates to the use of PDE 10A inhibitors for producing a medicament for the treatment and/or prophylaxis of neurodegenerative diseases, especially Parkinson's disease.

Abstract translation: 本发明涉及PDE 10A抑制剂在制备用于治疗和/或预防神经退行性疾病，特别是帕金森氏病的药物中的用途。

公开(公告)号：WO0100188A2

公开(公告)日：2001-01-04

申请号：PCT/EP0005571

申请日：2000-06-16

Applicant: BAYER AG ,  STOLTEFUSS JUERGEN ,  BRAEUNLICH GABRIELE ,  LOEGERS MICHAEL ,  SCHMECK CARSTEN ,  NIELSCH ULRICH ,  BECHEM MARTIN ,  GERDES CHRISTIAN ,  SPERZEL MICHAEL ,  LUSTIG KLEMENS ,  STUERMER WERNER

Inventor： STOLTEFUSS JUERGEN ,  BRAEUNLICH GABRIELE ,  LOEGERS MICHAEL ,  SCHMECK CARSTEN ,  NIELSCH ULRICH ,  BECHEM MARTIN ,  GERDES CHRISTIAN ,  SPERZEL MICHAEL ,  LUSTIG KLEMENS ,  STUERMER WERNER

IPC: A61K31/549 ,  A61P7/00 ,  A61P7/06 ,  A61P13/12 ,  A61P31/18 ,  C07D417/04 ,  C07D417/14 ,  A61K31/00

CPC classification number: C07D417/04 ,  A61K31/549 ,  C07D417/14

Abstract: The invention relates to the area of erythropoiesis, in particular to the use of tetrahydroquinolinyl-6-methyldihydrothiadiazinones of general formula (I) for preventing and/or treating anaemia. The invention also relates to novel tetrahydroquinolinyl-6-methyldihydrothiadiazinone derivatives and to the production thereof.

Abstract translation: 本发明涉及红细胞生成的领域。 特别地，使用6-四氢喹啉基，methyldihydrothiadiazinonen将描述用于贫血的预防和/或治疗的通式（I）。 此外，新的四氢喹啉基-6- methyldihydrothiadiazinon衍生物和它们的制备描述。

公开(公告)号：WO0045799A2

公开(公告)日：2000-08-10

申请号：PCT/EP0000517

申请日：2000-01-24

Applicant: BAYER AG ,  STOLTEFUSS JUERGEN ,  BRAEUNLICH GABRIELE ,  HINZEN BERTHOLD ,  KRAEMER THOMAS ,  PERNERSTORFER JOSEF ,  STUEDEMANN THOMAS ,  NIELSCH ULRICH ,  BECHEM MARTIN ,  LOHRMANN EMANUEL ,  GERDES CHRISTOPH ,  SPERZEL MICHAEL ,  LUSTIG KLEMENS ,  MAYR LORENZ

Inventor： STOLTEFUSS JUERGEN ,  BRAEUNLICH GABRIELE ,  HINZEN BERTHOLD ,  KRAEMER THOMAS ,  PERNERSTORFER JOSEF ,  STUEDEMANN THOMAS ,  NIELSCH ULRICH ,  BECHEM MARTIN ,  LOHRMANN EMANUEL ,  GERDES CHRISTOPH ,  SPERZEL MICHAEL ,  LUSTIG KLEMENS ,  MAYR LORENZ

IPC: A61K31/42 ,  A61K31/422 ,  A61K31/4439 ,  C07D261/08 ,  C07D409/04 ,  A61K31/00

CPC classification number: C07D409/04 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4439 ,  C07D261/08

Abstract: The invention relates to the use of substituted isoxazol carboxylic acids and derivatives of general formula (I) in the treatment and prophylaxis of anaemia disorders. The invention also relates to novel substances of formula (Ia) and novel methods for the production thereof.

Abstract translation: 本发明涉及使用取代的Isoxazolcarbonsäuren和通式（I）用于治疗和贫血的疾病的预防，以及上述通式（Ia）和新方法用于其制备的新材料的衍生物。

公开(公告)号：CZ293482B6

公开(公告)日：2004-05-12

申请号：CZ20003871

申请日：1999-04-07

Applicant: BAYER AG

Inventor： STOLTEFUSS JUERGEN ,  GOLDMANN SIEGFRIED ,  KRAEMER THOMAS ,  SCHLEMMER KARL-HEINZ ,  NIEWOEHNER ULRICH ,  PAESSENS ARNOLD ,  GRAEF ERWIN ,  LOTTMANN STEFAN ,  DERES KARL ,  WEBER OLAF ,  STOELTING JOERN

IPC: C07D213/78 ,  A61K31/506 ,  A61P1/16 ,  A61P31/12 ,  C07D213/00 ,  C07D213/84 ,  C07D215/00 ,  C07D239/00 ,  C07D239/22 ,  C07D277/62 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14

Abstract: The present invention relates to dihydropyrimidine compounds of the general formula I, optionally Ia, in which the substituents have specific meanings, process of their preparation, intermediates for their preparation, as well as their use for preparing medicaments suitable for treating and prophylaxis of viral diseases, in particular hepatitis B.

公开(公告)号：DE59902573D1

公开(公告)日：2002-10-10

申请号：DE59902573

申请日：1999-04-07

Applicant: BAYER AG

Inventor： STOELTING JOERN ,  STOLTEFUSS JUERGEN ,  GOLDMANN SIEGFRIED ,  KRAEMER THOMAS ,  SCHLEMMER KARL-HEINZ ,  NIEWOEHNER ULRICH ,  PAESSENS ARNOLD ,  GRAEF ERWIN ,  LOTTMANN STEFAN ,  DERES KARL ,  WEBER OLAF

IPC: C07D213/78 ,  A61K31/506 ,  A61P1/16 ,  A61P31/12 ,  C07D213/00 ,  C07D213/84 ,  C07D215/00 ,  C07D239/00 ,  C07D239/22 ,  C07D277/62 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14

Abstract: The invention relates to compounds of the formule