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    GENOMICS-BASED ALERTING SYSTEMS
    1.
    发明申请
    GENOMICS-BASED ALERTING SYSTEMS 审中-公开
    基于基因的报警系统

    公开(公告)号：WO2013141845A1

    公开(公告)日：2013-09-26

    申请号：PCT/US2012/029780

    申请日：2012-03-20

    Applicant: PATHWAY GENOMICS ,  PLANTE, James ,  BECKER, David

    Inventor： PLANTE, James ,  BECKER, David

    IPC: G01N33/48 ,  G01N33/50

    CPC classification number: G06F19/28 ,  G06F19/00 ,  G16H50/30

    Abstract: A computer alert about DNA sequence markers is arranged, whereby the genome of a specific human subject is considered in view of a plurality of discrete rules to affect alerts generated and transmitted in electronic form over standardized e-mail systems (Internet/SMTP protocol for example) to a user workstation equipped with a browser or custom application. Alerting systems include mechanical/ chemical systems for analyzing a human DNA sample, producing a genomic data set representing genetic indicators or markers on alleles of interest including SNPs associated with important trial traits disease and characteristics. The genome dataset is stored as a portion of a data a record having a one-to-one correspondence with membership in a membership database. Dynamic rules provides a query engine with logic which can be executed against membership data stored in accordance with standardized database procedures to produce a genomic result set from which appropriate alerts may be formed.

    Abstract translation: 安排关于DNA序列标记的计算机警报，由此鉴于多个离散规则来考虑特定人类受试者的基因组，以影响通过标准化电子邮件系统（例如，Internet / SMTP协议）产生和以电子形式发送的警报 ）到配有浏览器或定制应用程序的用户工作站。 警报系统包括用于分析人类DNA样品的机械/化学系统，产生代表遗传指标或基因等位基因的基因组数据集，包括与重要的试验性状疾病和特征相关的SNP。 基因组数据集作为与成员数据库中的成员资格具有一一对应关系的记录的数据的一部分存储。 动态规则提供具有逻辑的查询引擎，该逻辑可以针对根据标准化数据库过程存储的成员数据执行，以产生基因组结果集合，从而可以形成适当的警报。

    GENOME-BASED DRUG MANAGEMENT SYSTEMS
    2.
    发明申请
    GENOME-BASED DRUG MANAGEMENT SYSTEMS 审中-公开
    基于基因组的药物管理系统

    公开(公告)号：WO2013141842A2

    公开(公告)日：2013-09-26

    申请号：PCT/US2012/029704

    申请日：2012-03-19

    Applicant: PATHWAY GENOMICS ,  PLANTE, James ,  BECKER, David

    Inventor： PLANTE, James ,  BECKER, David

    IPC: C12Q1/68 ,  G06Q50/24

    CPC classification number: G06Q50/24 ,  G06F19/00

    Abstract: A drug management system based upon membership genomic data is coupled to cooperating external computing systems via an object server which prepares drug use reports for automated delivery in response to results that data output from the member database. Based on rules stored in a rules library a query engine runs tests on the stored member genetic information to identify and meet specified criteria.

    Abstract translation: 基于成员基因组数据的药物管理系统通过对象服务器耦合到协作的外部计算系统，对象服务器响应于从成员数据库输出的数据的结果来准备用于自动传送的药物使用报告。 基于存储在规则库中的规则，查询引擎运行对存储的成员遗传信息的测试以识别并满足指定的标准。

    PICTURE FRAME KIT
    4.
    发明申请
    PICTURE FRAME KIT 审中-公开
    图片框套件

    公开(公告)号：WO2016180603A1

    公开(公告)日：2016-11-17

    申请号：PCT/EP2016/058539

    申请日：2016-04-18

    Applicant: BECKER, David

    Inventor： BECKER, David

    IPC: A47G1/06

    CPC classification number: A47G1/0633

    Abstract: The invention provides a kit for making a picture frame comprising: a plurality of edge sections (1, 2, 3, 4) for forming into tubes and fixing in place so that each end of each tube is adjacent the end of another tube; a plurality of coupling sections (5, 6, 7, 8) for forming 3D couplers, wherein the 3D couplers can each be applied to two adjacent ends of two tubes to couple them together. There is also provided a picture frame and a method for making a picture frame.

    Abstract translation: 本发明提供一种用于制作相框的套件，包括：多个边缘部分（1,2,3,4），用于形成管并固定就位，使得每个管的每个端部与另一个管的端部相邻; 用于形成3D耦合器的多个耦合部分（5,6,7,8），其中所述3D耦合器可以分别被施加到两个管的两个相邻的端部以将它们耦合在一起。 还提供了画框和制作画框的方法。

    DUAL-MODE MICROFLUIDIC GENETICS TESTING PLATFORMS AND METHODS OF DUAL-MODE GENETICS TESTING USING SAME
    5.
    发明申请
    DUAL-MODE MICROFLUIDIC GENETICS TESTING PLATFORMS AND METHODS OF DUAL-MODE GENETICS TESTING USING SAME 审中-公开
    双模式微流感遗传测试平台和使用其的双模式遗传测试方法

    公开(公告)号：WO2013141835A1

    公开(公告)日：2013-09-26

    申请号：PCT/US2012/029586

    申请日：2012-03-18

    Applicant: PATHWAY GENOMICS ,  MORENO, Tanya ,  WANG, Cindy ,  BECKER, David

    Inventor： MORENO, Tanya ,  WANG, Cindy ,  BECKER, David

    IPC: C12M1/00 ,  G01N21/00

    CPC classification number: B01L3/50851 ,  B01L7/52 ,  B01L2300/0636

    Abstract: Dual mode genetics testing systems are devised about a single element testing platform. A microfluidic network and system of interconnected receiving cells and reaction vessels supports at the same time genotyping and copy number analysis where the platform may be subject to a common thermal cycle schedule to cause the proper reactions (DNA replication) necessary in both test types. Further, the microfluidic platform which includes reaction vessels for genotyping which are spatially removed from reaction vessels for copy number analysis, is coupled to optical scanner and detection systems specifically arranged to apply test specific detection routines on each of these distinct regions or portions of the dual mode test platform.

    Abstract translation: 关于单个元素测试平台设计了双模式遗传学测试系统。 互连接收细胞和反应容器的微流体网络和系统同时支持基因分型和拷贝数分析，其中平台可能经受常见的热循环进程，以引起两种测试类型中必需的适当反应（DNA复制）。 此外，包括用于基因分型的反应容器的微流体平台被从用于拷贝数分析的反应容器中空间移除，被耦合到光学扫描器和检测系统，该系统被特别设置为在这些不同区域或双重部分的每一个上应用测试特异性检测程序 模式测试平台。

    GENETIC SAMPLE COLLECTION SYSTEMS
    7.
    发明申请
    GENETIC SAMPLE COLLECTION SYSTEMS 审中-公开
    遗传样本收集系统

    公开(公告)号：WO2013106007A1

    公开(公告)日：2013-07-18

    申请号：PCT/US2012/029587

    申请日：2012-03-18

    Applicant: PATHWAY GENOMICS ,  BECKER, David ,  PLANTE, James ,  MORENO, Tanya ,  WANG, Cindy

    Inventor： BECKER, David ,  PLANTE, James ,  MORENO, Tanya ,  WANG, Cindy

    IPC: C12N15/10 ,  B01L3/14 ,  C12M3/08

    CPC classification number: B01L3/508 ,  A61B10/0051 ,  A61B10/0096 ,  A61B2010/0006 ,  B01L3/502 ,  B01L3/50825 ,  B01L99/00 ,  B01L2200/185 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/06 ,  B01L2300/0672 ,  C12N15/1006 ,  C12Q1/6806

    Abstract: Biological sample collection kits are devised with physical features to enable a high performance collection system which delivers preprocessed biological matter via conventional shipping means to a testing laboratories. In particular, users deposit biological matter such as saliva or blood into a receiving vessel. By sealing the container, the user causes release of a premixed solution containing preservatives and optionally lysis reagents. In addition, a purification agent is arranged to bind to target molecules and facilitate their removal from solution. These time consuming processes occur while the sample is in transit to the testing facility such that when it arrives, it is in a preconditioned state immediately ready for execution of washing steps. Thus, the high performance containers taught herein are useful for collection biological samples and performing initial process steps on received matter - steps which are largely effected during the shipping stage of the transfer process.

    Abstract translation: 生物样本收集套件设计有物理特征，以实现高性能收集系统，其通过常规运输方式将预处理的生物物质提供给测试实验室。 特别地，用户将生物物质如唾液或血液沉积到接收容器中。 通过密封容器，使用者引起含有防腐剂和任选裂解试剂的预混溶液的释放。 此外，将净化剂配置成与靶分子结合并促进它们从溶液中的去除。 这些耗时的过程发生在样品转运到测试设备时，使得当其到达时，它处于预处理状态，立即准备好执行洗涤步骤。 因此，本文中教导的高性能容器对于收集生物样品是有用的，并且对接收物质进行初步的处理步骤 - 在转移过程的运输阶段中主要影响的步骤。

    ULTRASONIC INTRACAVITY PROBE FOR 3D IMAGING
    9.
    发明申请
    ULTRASONIC INTRACAVITY PROBE FOR 3D IMAGING 审中-公开
    超声波入侵检测用于3D成像

    公开(公告)号：WO2005094689A1

    公开(公告)日：2005-10-13

    申请号：PCT/IB2005/050984

    申请日：2005-03-22

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  BECKER, David ,  WRAY, Terry ,  HART, Jeffrey

    Inventor： BECKER, David ,  WRAY, Terry ,  HART, Jeffrey

    IPC: A61B8/12

    CPC classification number: A61B8/4461 ,  A61B8/12 ,  A61B8/4281 ,  A61B8/445 ,  A61B8/483

    Abstract: An intracavity ultrasound probe includes a pivotally mounted array transducer which is oscillated to scan a volumetric region from within the body. The transducer is oscillated by a motor located in the probe handle. The array transducer is immersed in a liquid which acoustically couples ultrasonic energy between the elements of the transducer and the body. The acoustic coupling liquid is located in the distal tip of the probe shaft, where only 6 cc of liquid is required. The small amount of liquid reduces the weight of the shaft of the probe so that the center of gravity of the probe is in the handle, making the probe comfortable and easy to manipulate. The majority of parts in the probe shaft are made of aluminum or other low density materials, keeping the overall weight of the probe to about 250 grams.

    Abstract translation: 腔内超声波探头包括枢转安装的阵列换能器，其被振荡以从体内扫描体积区域。 传感器由位于探头手柄中的电机振荡。 将阵列换能器浸入液体中，该液体在换能器的元件和身体之间声学耦合超声波能量。 声耦合液体位于探头轴的远端，其中只需要6cc液体。 少量的液体减少了探头轴的重量，使得探头的重心位于手柄中，使得探头舒适且易于操作。 探头轴中的大部分部件由铝或其他低密度材料制成，将探头的总重量保持在250克左右。

    SPHERIFICATED DENTAL MEDICAMENT COMPOSITIONS
    10.
    发明申请
    SPHERIFICATED DENTAL MEDICAMENT COMPOSITIONS 审中-公开

    公开(公告)号：WO2019133828A1

    公开(公告)日：2019-07-04

    申请号：PCT/US2018/067887

    申请日：2018-12-28

    Applicant: PAPAZIAN, Mihran ,  BECKER, David

    Inventor： PAPAZIAN, Mihran ,  BECKER, David

    IPC: A61K8/11 ,  A61K8/73 ,  A61K8/49 ,  A61K8/34 ,  A61K8/21 ,  A61Q11/00

    CPC classification number: A61Q11/00 ,  A61K8/11 ,  A61K8/19 ,  A61K8/733 ,  A61K2800/87

    Abstract: A spherificated dental medicament that includes an outer membrane containing calcium alginate and an internal core containing at least one of a mouth rinse, a mouthwash, a dental paste, and a dental gel, A method of making the spherificated dental medicament includes immersing a dental medicament composition into a solution containing either a soluble alginate or calcium salt, the dental medicament composition comprising a calcium salt or a soluble alginate and at least one of a mouth rinse, a mouthwash, a dental paste and a dental gel, and then removing the dental medicament composition from the solution following formation of a membrane around the dental medicament composition.

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