公开(公告)号：WO1994015637A2

公开(公告)日：1994-07-21

申请号：PCT/US1993012187

申请日：1993-12-13

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  CERCEK, Boris ,  CERCEK, Lea

IPC: A61K39/395

CPC classification number: G01N33/5091 ,  A61K35/16 ,  A61K38/00 ,  A61K47/6845 ,  C07K7/08 ,  C07K14/4745 ,  C07K14/585 ,  C07K16/18 ,  G01N33/5011

Abstract: A method for blocking suppression of at least one of the natural killer (NK) and lymphocyte activated killer (LAK) immune defense mechanisms in lymphocytes of cancer patients comprises administering to a cancer patient an agent capable of blocking the immune defense suppressive activities of a peptide capable of inducing a detectable decrease in the structuredness of the cytoplasmic matrix in lymphocytes isolated from a patient with cancer (an SCM-factor peptide) in a quantity sufficient to block suppression of at least one of the natural killer (NK) and lymphocyte activated killer (LAK) immune defense mechanisms. The agent can comprise an antibody, an antisense peptide, or a factor present in blood plasma. The invention also includes pharmaceutical compositions for blocking suppression of immune defense and kits for stimulating immune response of cancer patients, as well as immunization methods to induce antibody to SCM-factor peptides.

Abstract translation: 抑制癌症患者淋巴细胞中的至少一种天然杀伤（NK）和淋巴细胞活化的杀伤（LAK）免疫防御机制的抑制方法包括向癌症患者施用能够阻断肽的免疫防御抑制活性的试剂 能够诱导分离自患有癌症的淋巴细胞（SCM-因子肽）中的足以阻断至少一种天然杀伤（NK）和淋巴细胞活化的杀伤剂的抑制的量的淋巴细胞的细胞质基质的结构化的可检测的降低 （LAK）免疫防御机制。 该试剂可以包含抗体，反义肽或存在于血浆中的因子。 本发明还包括用于阻断免疫防御的药物组合物和用于刺激癌症患者的免疫应答的试剂盒，以及用于诱导针对SCM-因子肽的抗体的免疫方法。