公开(公告)号：DE2726840A1

公开(公告)日：1977-12-15

申请号：DE2726840

申请日：1977-06-14

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01T1/204

公开(公告)号：AT43018T

公开(公告)日：1989-05-15

申请号：AT85902827

申请日：1985-05-15

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01T1/204

公开(公告)号：DE2746763A1

公开(公告)日：1978-04-20

申请号：DE2746763

申请日：1977-10-18

Applicant: BECKMAN INSTRUMENTS INC

Inventor： LUITWIELER JUN SAMUEL H ,  HORROCKS DONALD L

IPC: G01T1/16 ,  G01T1/20

Abstract: A method and apparatus for the calibration of a gamma radiation measurement instrument to be used over any of a number of different absolute energy ranges. The method includes the steps of adjusting the overall signal gain associated with pulses which are derived from detected gamma rays, until the instrument is calibrated for a particular absolute energy range; then storing parameter settings corresponding to the adjusted overall signal gain, and repeating the process for other desired absolute energy ranges. The stored settings can be subsequently retrieved and reapplied so that test measurements can be made using a selected one of the absolute energy ranges. Means are provided for adjusting the overall signal gain by varying the voltage supplied to a multiplier phototube included in the instrument, or by varying the gain of attenuators coupled to the output of the phototube. A specific technique is disclosed for making coarse, then fine adjustments to the signal gain, for rapid convergence on the required calibration settings.

公开(公告)号：AT42642T

公开(公告)日：1989-05-15

申请号：AT85902825

申请日：1985-05-15

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01T1/204

公开(公告)号：FI860291A

公开(公告)日：1986-01-21

申请号：FI860291

申请日：1986-01-21

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01F1/704 ,  G01T1/204 ,  G01T

Abstract: A method for use with liquid scintillation flow systems including flowing a mixture comprising a sample and a liquid scintillation medium through a flow detector, the liquid scintillation medium including a radionuclide marker having an energy distribution different from the sample. A pulse height distribution spectrum is determined and a unique point on the portion of the pulse height distribution spectrum representing the energy spectrum of the medium is found, a pulse height value related to such unique point providing a value related to the degree of quench present in the mixture. By comparing such pulse height value to a pulse height value obtained in a like manner for a calibration standard, a degree of quench present in the mixture is indicated. Furthermore, the counts detected for the liquid scintillation medium during a measurement period may be related to the specific activity of the liquid scintillation medium to determine the volume of liquid scintillation medium flowing during the measurement period. The volume of sample flowing during such period may also be determined by relating the liquid scintillation medium volume to a ratio of sample to liquid scintillation medium flowing through the flow detector. Sample count rate is corrected for quench and sample specific activity is determined.

公开(公告)号：DE2903050A1

公开(公告)日：1979-08-02

申请号：DE2903050

申请日：1979-01-26

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01T1/172 ,  G01T1/178 ,  G01T1/20

公开(公告)号：DE3570138D1

公开(公告)日：1989-06-15

申请号：DE3570138

申请日：1985-05-15

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01F1/704 ,  G01T1/204

Abstract: A method for use with liquid scintillation flow systems including flowing a mixture comprising a sample and a liquid scintillation medium through a flow detector, the liquid scintillation medium including a radionuclide marker having an energy distribution different from the sample. A pulse height distribution spectrum is determined and a unique point on the portion of the pulse height distribution spectrum representing the energy spectrum of the medium is found, a pulse height value related to such unique point providing a value related to the degree of quench present in the mixture. By comparing such pulse height value to a pulse height value obtained in a like manner for a calibration standard, a degree of quench present in the mixture is indicated. Furthermore, the counts detected for the liquid scintillation medium during a measurement period may be related to the specific activity of the liquid scintillation medium to determine the volume of liquid scintillation medium flowing during the measurement period. The volume of sample flowing during such period may also be determined by relating the liquid scintillation medium volume to a ratio of sample to liquid scintillation medium flowing through the flow detector. Sample count rate is corrected for quench and sample specific activity is determined.

公开(公告)号：CA1249077A

公开(公告)日：1989-01-17

申请号：CA483555

申请日：1985-06-10

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01T1/204

Abstract: QUENCH, VOLUME AND ACTIVITY DETERMINATIONS IN A LIQUID SCINTILLATION FLOW SYSTEM A method for use with liquid scintillation flow systems including flowing a mixture comprising a sample and a liquid scintillation medium through a flow detector, the liquid scintillation medium including a radionuclide marker having an energy distribution different from the sample. A pulse height distribution spectrum is determined and a unique point on the portion of the pulse height distribution spectrum representing the energy spectrum of the medium is found, a pulse height value related to such unique point providing a value related to the degree of quench present in the mixture. By comparing such pulse height value to a pulse height value obtained in a like manner for a calibration standard, a degree of quench present in the mixture is indicated. Furthermore, the counts detected for the liquid scintillation medium during a measurement period may be related to the specific activity of the liquid scintillation medium to determine the volume of liquid scintillation medium flowing during the measurement period. The volume of sample flowing during such period may also be determined by relating the liquid scintillation medium volume to a ratio of sample to liquid scintillation medium flowing through the flow detector. Sample count rate is corrected for quench and sample specific activity is determined.

公开(公告)号：CA1249076A

公开(公告)日：1989-01-17

申请号：CA483557

申请日：1985-06-10

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HORROCKS DONALD L

IPC: G01T1/204

Abstract: METHOD AND APPARATUS FOR INDICATING QUENCH OF A LIQUID SCINTILLATION SOLUTION A method and apparatus for indicating quench associated with a liquid scintillation solution wherein the solution includes a sample, a solvent and a solute. The method includes exposing the solution to flashes of light, detecting a pulse height spectrum for scintillations produced in the solution in response to the light flashes, determining a unique point on such pulse height spectrum, and relating the unique point to a corresponding pulse height value, such pulse height value providing an indication of quench associated with the solution. The wavelength of light preferably excites essentially only the solvent and the light flash intensity and duration is such that the pulse height spectrum produced in response to the light flashes does not overlap a pulse height spectrum for the sample in the solution. An attribute of the shape of the light pulse height spectrum may be examined to provide an indication of the homogeneous or non-homogeneous nature of the quench present in the solution.

公开(公告)号：FI860289A0

公开(公告)日：1986-01-21

申请号：FI860289

申请日：1986-01-21

Applicant: BECKMAN INSTRUMENTS INC

Inventor： KOLB ALFRED J ,  HORROCKS DONALD L

IPC: G01T1/204 ,  G01T