公开(公告)号：JPS5313492A

公开(公告)日：1978-02-07

申请号：JP6402777

申请日：1977-06-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROBAATO JIEI ANDAASON ,  ROBAATO EMU SUTATSUDOHORUMU

IPC: G01J3/00 ,  G01N21/27 ,  G01N21/47 ,  G01N21/82 ,  G01N33/536 ,  G01N33/557

公开(公告)号：JPS57156544A

公开(公告)日：1982-09-27

申请号：JP20380081

申请日：1981-12-18

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROBAATO JIEI ANDAASON

IPC: G01N21/76 ,  G01N21/64 ,  G01N21/78 ,  G01N31/00 ,  G01N33/53 ,  G01N33/536 ,  G01N33/58 ,  G01N35/00

Abstract: A system for chemically analyzing antigens or antibodies by initiating an antigen-antibody reaction in a reaction zone and measuring the light scattered by a precipitate produced by the reaction to determine the antigen or antibody concentration. In order to signal the start of the reaction, a fluorescent tagging substance is included with at least the last antigen or antibody reaction component introduced into the reaction zone. The fluorescent tagging substance does not enter into the antigen-antibody reaction and is selected to emit light in a bandwidth spectrally separated from the light scattered by the precipitate. The reaction zone is monitored for the presence of the tagging substance, and when the substance is detected a trigger signal is generated to signal the start of the reaction. By including a tagging substance with each component of the reaction and by monitoring the reaction zone for the presence of each tagging substance, a trigger signal is generated only if each reaction component is present.

公开(公告)号：JPS52149195A

公开(公告)日：1977-12-12

申请号：JP6341077

申请日：1977-06-01

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROBAATO JIEI ANDAASON

IPC: G01N21/76 ,  G01N21/64 ,  G01N21/78 ,  G01N31/00 ,  G01N33/53 ,  G01N33/536 ,  G01N33/58 ,  G01N35/00

Abstract: A system for chemically analyzing antigens or antibodies by initiating an antigen-antibody reaction in a reaction zone and measuring the light scattered by a precipitate produced by the reaction to determine the antigen or antibody concentration. In order to signal the start of the reaction, a fluorescent tagging substance is included with at least the last antigen or antibody reaction component introduced into the reaction zone. The fluorescent tagging substance does not enter into the antigen-antibody reaction and is selected to emit light in a bandwidth spectrally separated from the light scattered by the precipitate. The reaction zone is monitored for the presence of the tagging substance, and when the substance is detected a trigger signal is generated to signal the start of the reaction. By including a tagging substance with each component of the reaction and by monitoring the reaction zone for the presence of each tagging substance, a trigger signal is generated only if each reaction component is present.