公开(公告)号：DE3751585T3

公开(公告)日：2004-08-05

申请号：DE3751585

申请日：1987-11-17

Applicant: BIO RAD LAB INC N D GES D STAA

Inventor： LINSLEY PETER S ,  HORN DIANE ,  BROWN JOSEPH P

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/574 ,  G01N33/577 ,  C12N5/12 ,  C07K16/28 ,  G01N33/68

Abstract: Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.