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    PROCESS DESIGN USING MASS SPECTROMETRY
    1.
    发明申请
    PROCESS DESIGN USING MASS SPECTROMETRY 审中-公开
    使用大量光谱的工艺设计

    公开(公告)号：WO2010078554A1

    公开(公告)日：2010-07-08

    申请号：PCT/US2010/020047

    申请日：2010-01-04

    Applicant: BIO-RAD LABORATORIES, INC. ,  BOSCHETTI, Egisto

    Inventor： BOSCHETTI, Egisto

    IPC: G01N33/68 ,  G01N30/00

    CPC classification number: G01N33/6848 ,  C07K1/16 ,  G01N30/8675 ,  G01N2030/8831

    Abstract: The present invention provides a facile and efficient method for determining a chromatographic protocol for separating a target protein from one or more second protein impurity. Also provided is a database facilitating the determination of an appropriate separation protocol.

    Abstract translation: 本发明提供了一种用于确定用于从一种或多种第二种蛋白质杂质分离靶蛋白质的色谱方案的简便有效的方法。 还提供了便于确定适当分离方案的数据库。

    POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY
    3.
    发明申请
    POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY 审中-公开

    公开(公告)号：WO2007061643A3

    公开(公告)日：2007-05-31

    申请号：PCT/US2006/043695

    申请日：2006-11-09

    Applicant: BIO-RAD LABORATORIES, INC. ,  BOSCHETTI, Egisto ,  LOMAS, Lee, O.

    Inventor： BOSCHETTI, Egisto ,  LOMAS, Lee, O.

    IPC: H01J49/40

    Abstract: A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.

    METHOD FOR PURIFYING PROTEINS
    5.
    发明申请
    METHOD FOR PURIFYING PROTEINS 审中-公开
    净化蛋白质的方法

    公开(公告)号：WO2006102547A2

    公开(公告)日：2006-09-28

    申请号：PCT/US2006/010656

    申请日：2006-03-22

    Applicant: CIPHERGEN BIOSYSTEMS, INC. ,  BOSCHETTI, Egisto ,  LOMAS, Lee

    Inventor： BOSCHETTI, Egisto ,  LOMAS, Lee

    IPC: C40B40/04 ,  C40B40/08 ,  C40B40/10

    CPC classification number: C07K1/047 ,  C07K1/22

    Abstract: The present invention provides methods and kits for purifying a target protein group. The method comprises the steps of contacting a sample comprising at least 95% of the target protein group and at most 5% of contaminating proteins with a library of binding moieties having different binding moieties, binding the contaminating proteins and a minority of the target protein group to the library of binding moieties, separating the unbound target protein group from the proteins bound to the library of binding moieties and collecting the unbound target protein. The collected target protein is more pure than the target protein group in the sample.

    Abstract translation: 本发明提供了用于纯化靶蛋白质组的方法和试剂盒。 该方法包括以下步骤：将包含至少95％的目标蛋白质组和至多5％的污染蛋白质的样品与具有不同结合部分的结合部分的文库结合，将污染性蛋白质和少量靶蛋白质组 到结合部分的文库，将未结合的靶蛋白基团与结合到结合部分文库的蛋白质分离并收集未结合的靶蛋白质。 收集的目标蛋白质比样品中的目标蛋白质组更为纯净。

    DIVERSE CHEMICAL LIBRARIES BOUND TO SMALL PARTICLES WITH PARAMAGNETIC PROPERTIES
    10.
    发明申请
    DIVERSE CHEMICAL LIBRARIES BOUND TO SMALL PARTICLES WITH PARAMAGNETIC PROPERTIES 审中-公开
    分散化学图书馆附有具有参照性质的小颗粒

    公开(公告)号：WO2006102542A2

    公开(公告)日：2006-09-28

    申请号：PCT/US2006/010647

    申请日：2006-03-22

    Applicant: CIPHERGEN BIOSYSTEMS, INC. ,  BOSCHETTI, Egisto ,  LOMAS, Lee

    Inventor： BOSCHETTI, Egisto ,  LOMAS, Lee

    IPC: C40B40/04 ,  C40B40/08 ,  C40B40/10

    CPC classification number: C07K1/047 ,  C07K1/22

    Abstract: The present invention provides diverse chemical libraries bound to small particle with paramagnetic properties. Typically, the chemical structures comprise a plurality of different chemical moieties, the particles are paramagnetic and have a diameter between about 100 nm and about 10 microns, the chemical structures bound to each particular particle have substantially the same structure and the combinatorial library comprises at least 100,000 different chemical structures.

    Abstract translation: 本发明提供了与具有顺磁特性的小颗粒结合的不同化学文库。 通常，化学结构包括多个不同的化学部分，颗粒是顺磁性的并且具有约100nm至约10微米之间的直径，与每个特定颗粒结合的化学结构具有基本上相同的结构，组合文库至少包含 100,000种不同的化学结构。

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