公开(公告)号：CA2720615C

公开(公告)日：2016-06-07

申请号：CA2720615

申请日：2009-04-07

Applicant: BIO-RAD LABORATORIES INC

Inventor： GAGNON PETER S ,  CHEN HONG ,  FROST RUSS

IPC: C07K16/00 ,  A23J1/00 ,  B01D15/10 ,  C07K1/16 ,  C07K1/22

Abstract: Methods, kits and apparatuses for chromatography purification of antibodies are provided. In some embodiments, antibodies are purified by mixed mode chromatography that does not comprise hydroxyapatite (HT) or fluorapatite (FT). The mixed mode chromatography step is then followed by a HT/FT chromatography step.

公开(公告)号：EP2986625A4

公开(公告)日：2016-12-14

申请号：EP15761242

申请日：2015-03-13

Applicant: BIO-RAD LABORATORIES INC ,  RENSSELAER POLYTECH INST

Inventor： CRAMER STEVEN ,  WOO JAMES ,  CHEN HONG ,  LIAO JIALI ,  FROST RUSSELL

IPC: B01J20/286 ,  B01J20/28 ,  B01J20/32 ,  B01J39/20 ,  B01J39/26 ,  C07K1/16

CPC classification number: B01J39/20 ,  B01J20/28004 ,  B01J20/28085 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3253 ,  B01J20/3285 ,  B01J39/26 ,  B01J2220/82 ,  C07K1/165

Abstract: Mixed mode ligands, as well their use for purifying proteins, are provided.