公开(公告)号：WO9507452A2

公开(公告)日：1995-03-16

申请号：PCT/US9409505

申请日：1994-08-23

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： NEEL GARY T ,  PARKER JAMES R ,  COLLINS RICK L ,  STORVICK DAVID E ,  THOMECZEK CHARLES L JR ,  MURPHY WILLIAM J ,  LENNERT GEORGE R ,  YOUNG MORRIS J ,  KENNEDY DANIEL L

IPC: G01N11/00 ,  G01N11/06 ,  G01N11/10 ,  G01N21/03 ,  G01N21/05 ,  G01N21/47 ,  G01N21/75 ,  G01N21/86 ,  G01N33/483 ,  G01N33/49 ,  G01N33/86 ,  G01N35/00

CPC classification number: G01N35/00594 ,  G01N11/06 ,  G01N21/0303 ,  G01N21/0332 ,  G01N21/8483 ,  G01N33/4905 ,  G01N35/00693

Abstract: An instrument (100) and a method for determining a coagulation characteristic of blood, a blood fraction or a control comprise a radiation-reflective surface (194), a first source (244) for irradiating the surface (194), and a first detector (242) for detecting radiation reflected from the surface (194). A cuvette (101) holds a sample (514) of the blood, blood fraction or control the coagulation characteristic of which is to be determined. The cuvette (101) has two opposed walls (506, 508) substantially transparent to the source (244) radiation and reflected radiation. The first source (244) and first detector (242) are disposed adjacent a first one (508) of the two opposed walls (506, 508) and the radiation reflective surface (194) is disposed adjacent a second (506) or the two opposed walls (506, 508).

Abstract translation: 仪器（100）和用于确定血液，血液部分或对照物的凝血特性的方法包括辐射反射表面（194），用于照射表面（194）的第一源（244）和第一检测器 （242），用于检测从表面（194）反射的辐射。 试管（101）容纳要确定的凝血特征的血液，血液成分或控制样品（514）。 试管（101）具有对源（244）基本上透明的辐射和反射辐射的两个相对的壁（506,508）。 第一源（244）和第一检测器（242）被布置成与两个相对的壁（506,508）中的第一源（508）相邻并且辐射反射表面（194）邻近第二（506）或两个 相对的壁（506,508）。

公开(公告)号：EP0591226A4

公开(公告)日：1994-01-07

申请号：EP92907477

申请日：1992-02-27

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： ARBUCKLE STEVEN R ,  BOYD WILLIAM RONALD ,  GRANT MICHAEL E DOVER HIGHWAY ,  GREGORY MARK A ,  GRAY RUSSELL T ,  JOST FRIEDRICH ,  KENNEDY DANIEL L ,  PERIN DINO ,  RIEDEL RICHARD ,  STORVICK DAVID E ,  STOUGHTON JOHN W

IPC: G01N21/47 ,  G01N21/77 ,  G01N21/86 ,  G01N33/52 ,  G01J1/46

CPC classification number: G01N21/8483 ,  G01N2021/478 ,  G01N2201/1214 ,  G01N2201/122 ,  G01N2201/12723 ,  Y10T436/10

Abstract: A method and apparatus (10) for determining the remission of a chemistry which reacts with a medically significant component of a body fluid is provided. The method and apparatus (10) includes irradiating the chemistry with a radiation source (160) and detecting the rate of change of remission of the chemistry (106) with respect to time.

Abstract translation: 提供了用于确定与体液的医学上重要的组分反应的化学物质的缓解的方法和装置（10）。 该方法和装置（10）包括用辐射源（160）照射化学物质并检测化学物质（106）的缓解相对于时间的变化率。

公开(公告)号：EP0716739A4

公开(公告)日：1997-06-18

申请号：EP94925997

申请日：1994-08-23

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： NEEL GARY T ,  PARKER JAMES R ,  COLLINS RICK L ,  STORVICK DAVID E ,  THOMECZEK CHARLES L JR ,  MURPHY WILLIAM J ,  LENNERT GEORGE R ,  YOUNG MORRIS J ,  KENNEDY DANIEL L

IPC: G01N11/00 ,  G01N11/06 ,  G01N11/10 ,  G01N21/03 ,  G01N21/05 ,  G01N21/47 ,  G01N21/75 ,  G01N21/86 ,  G01N33/483 ,  G01N33/49 ,  G01N33/86 ,  G01N35/00

CPC classification number: G01N35/00594 ,  G01N11/06 ,  G01N21/0303 ,  G01N21/0332 ,  G01N21/8483 ,  G01N33/4905 ,  G01N35/00693

Abstract: An instrument (100) and a method for determining a coagulation characteristic of blood, a blood fraction or a control comprise a radiation-reflective surface (194), a first source (244) for irradiating the surface (194), and a first detector (242) for detecting radiation reflected from the surface (194). A cuvette (101) holds a sample (514) of the blood, blood fraction or control the coagulation characteristic of which is to be determined. The cuvette (101) has two opposed walls (506, 508) substantially transparent to the source (244) radiation and reflected radiation. The first source (244) and first detector (242) are disposed adjacent a first one (508) of the two opposed walls (506, 508) and the radiation reflective surface (194) is disposed adjacent a second (506) or the two opposed walls (506, 508).

公开(公告)号：EP0716738A4

公开(公告)日：1996-09-18

申请号：EP94925970

申请日：1994-08-18

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： PARKER JAMES R ,  MURPHY WILLIAM J ,  THOMECZEK CHARLES L JR ,  KENNEDY DANIEL L ,  NEEL GARY T ,  STORVICK DAVID E

IPC: G01N33/86 ,  G01N11/10 ,  G01N11/16 ,  G01N27/74 ,  G01N33/49

CPC classification number: G01N33/4905 ,  G01N11/16

Abstract: An instrument (100) monitors the coagulation of coagulable fluid blood, blood fraction or a control (514) by combining (101) the coagulable fluid (514) with particles which are affected by a magnetic field so that the particles become suspended relatively freely in the fluid. A time-varying magnetic field (2 Hz) causes the particles to be reoriented as the magnetic field varies. The reorientation changes as the fluid (514) coagulates owing to the fluid's (514's) changing viscosity. An electromagnet (140) creates the time-varying magnetic field. The electromagnet (140) includes a core (150) comprising a first leg (148), an electrically conductive coil (144) for creating a time-varying magnetic flux in the core (150), and a return (152) for the time-varying magnetic flux. The first leg (148) and the flux return (152) together comprise a generally E-shaped core (150) of ferromagnetic material. A bobbin (146) is provided on the first leg (148) and the electrically conductive coil (144) is wound on the bobbin (146).

Abstract translation: 仪器（100）通过将可凝结流体（514）与受磁场影响的颗粒组合（101）来监测可凝结流体血液，血液部分或对照（514）的凝结，使得颗粒相对自由地悬浮于 流体。 随着磁场的变化，随时间变化的磁场（2赫兹）使颗粒重新定向。 随着流体（514）由于流体（514）的粘度改变而凝结，重新定向改变。 电磁体（140）产生时变磁场。 电磁体（140）包括芯部（150），该芯部（150）包括第一腿部（148），用于在芯部（150）中产生随时间变化的磁通量的导电线圈（144） 变磁通量。 第一腿部（148）和通量返回部（152）一起包括铁磁材料的大致E形铁芯（150）。 线轴（146）设置在第一腿部（148）上并且导电线圈（144）缠绕在线轴（146）上。

公开(公告)号：CA2168859A1

公开(公告)日：1995-03-16

申请号：CA2168859

申请日：1994-08-23

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： NEEL GARY T ,  PARKER JAMES R ,  COLLINS RICK L ,  STORVICK DAVID E ,  THOMECZEK CHARLES L JR ,  MURPHY WILLIAM J ,  LENNERT GEORGE R ,  YOUNG MORRIS J ,  KENNEDY DANIEL L

IPC: G01N11/00 ,  G01N11/06 ,  G01N11/10 ,  G01N21/03 ,  G01N21/05 ,  G01N21/47 ,  G01N21/75 ,  G01N21/86 ,  G01N33/483 ,  G01N33/49 ,  G01N33/86 ,  G01N35/00 ,  G01N11/02 ,  G01N21/49

Abstract: An instrument (100) and a method for determining a coagulation characteristic of blood, a blood fraction or a control comprise a radiationreflective surface (194), a first source (244) for irradiating the surface (194), and a first detector (242) for detecting radiation reflected from the surface (194). A cuvette (101) holds a sample (514) of the blood, blood fraction or control the coagulation characteristic of which is to be determined. The cuvette (101) has two opposed walls (506, 508) substantially transparent to the source (244) radiation and reflected radiation. The first source (244) and first detector (242) are disposed adjacent a first one (508) of the two opposed walls (506, 508) and the radiation reflective surface (194) is disposed adjacent a second (5063 or the two opposed walls (506, 508).

公开(公告)号：CA2168859C

公开(公告)日：2007-01-09

申请号：CA2168859

申请日：1994-08-23

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： NEEL GARY T ,  PARKER JAMES R ,  COLLINS RICK L ,  STORVICK DAVID E ,  THOMECZEK CHARLES L JR ,  MURPHY WILLIAM J ,  LENNERT GEORGE R ,  YOUNG MORRIS J ,  KENNEDY DANIEL L

IPC: G01N21/03 ,  G01N11/00 ,  G01N11/02 ,  G01N11/06 ,  G01N11/10 ,  G01N21/05 ,  G01N21/47 ,  G01N21/49 ,  G01N21/75 ,  G01N21/84 ,  G01N21/86 ,  G01N33/483 ,  G01N33/49 ,  G01N33/86 ,  G01N35/00

Abstract: An instrument (100) and a method for determining a coagulation characteristic of blood, a blood fraction or a control comprise a radiation-reflective surface (194), a first source (244) for irradiating the surface (194), and a first detector (242) for detecting radiation reflected from the surfac e (194). A cuvette (101) holds a sample (514) of the blood, blood fraction or control the coagulation characteristic of which is to be determined. The cuvette (101) has two opposed walls (506, 508) substantially transparent to the source (244) radiation and reflected radiation. The first source (244) and first detector (242) are disposed adjacent a first one (508) of the two opposed walls (506, 508) and the radiation reflective surface (194) is disposed adjacent a second (506) or the two opposed walls (506, 508).

公开(公告)号：CA2170043C

公开(公告)日：2003-12-09

申请号：CA2170043

申请日：1994-08-18

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： PARKER JAMES R ,  MURPHY WILLIAM J ,  THOMECZEK CHARLES L JR ,  KENNEDY DANIEL L ,  NEEL GARY T ,  STORVICK DAVID E

IPC: G01N33/86 ,  G01N11/10 ,  G01N11/16 ,  G01N27/74 ,  G01N33/49 ,  C12Q1/56

Abstract: An instrument (100) monitors the coagulation of coagulable fluid blood, blood fraction or a control (514) by combining (101) the coagulable fluid (514) with particles which are affected by a magnetic field so that the particles become suspended relatively freely in the fluid. A time-varying magnetic field (2 Hz) causes the particles to be reori- ented as the magnetic field varies. The reorientation changes as the fluid (514) coagulates owing to the fluid's (514's) changing viscosity. An electromagnet (140) creates the time-varying magnetic field. The electromagnet (140) includes a core (150) comprising a first leg (148), an electrically conductive coil (144) for creating a time-varying magnetic flux in the core (150), and a return (152) for the time-varying magnetic flux. The first leg (148) and the flux return (152) together comprise a generally E-shaped core (150) of ferromagnetic material. A bobbin (146) is provided on the first leg (148) and the electrically conduc- tive coil (144) is wound on the bobbin (146).

公开(公告)号：CA2170043A1

公开(公告)日：1995-03-09

申请号：CA2170043

申请日：1994-08-18

Applicant: BOEHRINGER MANNHEIM CORP

Inventor： PARKER JAMES R ,  MURPHY WILLIAM J ,  THOMECZEK CHARLES J JR ,  KENNEDY DANIEL L ,  NEEL GARY T ,  STORVICK DAVID E

IPC: G01N33/86 ,  G01N11/10 ,  G01N11/16 ,  G01N27/74 ,  G01N33/49 ,  C12Q1/56

Abstract: An instrument (100) monitors the coagulation of coagulable fluid blood, blood fraction or a control (514) by combining (101) the coagulable fluid (514) with particles which are affected by a magnetic field so that the particles become suspended relatively freely in the fluid. A time-varying magnetic field (2 Hz) causes the particles to be reoriented as the magnetic field varies. The reorientation changes as the fluid (514) coagulates owing to the fluid's (514's) changing viscosity. An electromagnet (140) creates the time-varying magnetic field. The electromagnet (140) includes a core (150) comprising a first leg (148), an electrically conductive coil (144) for creating a time-varying magnetic flux in the core (150), and a return (152) for the time-varying magnetic flux. The first leg (148) and the flux return (152) together comprise a generally E-shaped core (150) of ferromagnetic material. A bobbin (146) is provided on the first leg (148) and the electrically conductive coil (144) is wound on the bobbin (146).