公开(公告)号：WO1991016315A1

公开(公告)日：1991-10-31

申请号：PCT/US1991002522

申请日：1991-04-12

Applicant: BROWN UNIVERSITY RESEARCH FOUNDATION

Inventor： BROWN UNIVERSITY RESEARCH FOUNDATION ,  NAGUIB, Fardos, N., M. ,  EL KOUNI, Mahmoud, H. ,  PANZICA, Raymond, P. ,  CHA, Sungman

IPC: C07D239/62

CPC classification number: C07D239/62

Abstract: 5-benzyl barbiturate compounds for use as water-soluble uridine phosphorylase inhibitors are disclosed. These compounds are useful for reducing the toxicity and anemia induced by antiviral drugs, such as AZT, as well as for potentiating anticancer drugs and combatting their host-toxicity.

公开(公告)号：EP0526537B1

公开(公告)日：1995-07-12

申请号：EP91908585.2

申请日：1991-04-12

Applicant: BROWN UNIVERSITY RESEARCH FOUNDATION

Inventor： NAGUIB, Fardos, N., M. ,  EL KOUNI, Mahmoud, H. ,  PANZICA, Raymond, P. ,  CHA, Sungman

IPC: C07D239/62 ,  A61K31/515

CPC classification number: C07D239/62

Abstract: 5-benzyl barbiturate compounds for use as water-soluble uridine phosphorylase inhibitors are disclosed. These compounds are useful for reducing the toxicity and anemia induced by antiviral drugs, such as AZT, as well as for potentiating anticancer drugs and combatting their host-toxicity.

公开(公告)号：EP0526537A1

公开(公告)日：1993-02-10

申请号：EP91908585.0

申请日：1991-04-12

Applicant: BROWN UNIVERSITY RESEARCH FOUNDATION

Inventor： NAGUIB, Fardos, N., M. ,  EL KOUNI, Mahmoud, H. ,  PANZICA, Raymond, P. ,  CHA, Sungman

IPC: A61K31 ,  A61P35 ,  A61P39 ,  A61P43 ,  C07D239

CPC classification number: C07D239/62

Abstract: L'invention concerne des composés au barbiturique 5-benzyle destinés à être utilisés en tant qu'inhibiteur de phosphorylase uridine soluble dans l'eau. Ces composés sont utiles pour réduire la toxicité et l'anémie induites par les médicaments antiviraux, comme l'AZT, elles sont également utiles pour renforcer les médicaments anticancer et pour combattre leur toxicité dans les tissus-hôte.