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公开(公告)号：DE69811505T2
公开(公告)日：2003-11-13
申请号：DE69811505
申请日：1998-07-27
Applicant: BUCKMAN LABOR INC
Inventor： MCNEEL E , WHITTEMORE S , BRYANT D , VUNK H
Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R1R2NS(O)2(OH). In this formula, R1 and R2 are independently a hydrogen, a C4-C20 alkyl group or a cyclohexyl group. However, R1 and R 2 are not both hydrogen. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula:In the heterocyclic ring, X is O, NH, or CH2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. The present invention also relates to a composition containing sulfamic acids or salts thereof useable in the above methods. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
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公开(公告)号：DE69811505D1
公开(公告)日：2003-03-27
申请号：DE69811505
申请日：1998-07-27
Applicant: BUCKMAN LABOR INC
Inventor： MCNEEL E , WHITTEMORE S , BRYANT D , VUNK H
Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one sulfamic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The sulfamic acid used in the method of the invention has the formula R1R2NS(O)2(OH). In this formula, R1 and R2 are independently a hydrogen, a C4-C20 alkyl group or a cyclohexyl group. However, R1 and R 2 are not both hydrogen. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula:In the heterocyclic ring, X is O, NH, or CH2. The salt of sulfamic acid can be an acid salt or quaternized sulfamic acid salt. The present invention also relates to a composition containing sulfamic acids or salts thereof useable in the above methods. The compositions comprise at least one sulfamic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
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公开(公告)号：DE69534714T2
公开(公告)日：2006-07-13
申请号：DE69534714
申请日：1995-01-12
Applicant: BUCKMAN LABOR INC
Inventor： MCNEEL E
Abstract: A method for controlling the chemical treatment of a solution comprises the steps of feeding a treatment chemical into the solution, applying an external voltage across a reference electrode and a working electrode of a voltammetric sensor while the electrodes are immersed in the solution, measuring a current that flows through the working electrode, converting the measured current into a feedback signal indicative of the concentration of treatment chemical in the solution, and using the feedback signal to control the rate of feeding the treatment chemical.
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公开(公告)号：DE69902821D1
公开(公告)日：2002-10-10
申请号：DE69902821
申请日：1999-11-30
Applicant: BUCKMAN LABOR INC
Inventor： HEINDEL D , WHITTEMORE S , GUILLON CHRISTOPHE , RAPP D , LASKIN D , MCNEEL E , HECK E
IPC: C07D493/04 , A61K31/35
Abstract: The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula(V):In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR1R2, or (N+R1R2R3)X-, R1 and R2 are independently a C1-C6 alkyl, or R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring, or when T is (N+R1R2R3)X-, R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R3 is hydrogen, a C1-C12 alkyl, or, when R1 and R2 together with the nitrogen form a heterocyclic aromatic ring, R3 is a double bond within the heterocyclic aromatic ring; X- is a halide. In another embodiment, the invention relates to processes for preparing 4'-substituted-4',5'-dihydropsoralen compounds described above. The compounds of the invention have beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.
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Patent Agency Ranking
公开(公告)号：DE69834340D1
公开(公告)日：2006-06-01
申请号：DE69834340
申请日：1998-07-27
Applicant: BUCKMAN LABOR INC
Inventor： MCNEEL E , WHITTEMORE S , BRYANT D , VUNK H
Abstract: The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacterial adhesion to the submergible surface. The invention also relates to a method for controlling biofouling of an aqueous system. This method adds an effective amount of at least one amino methyl phosphonic acid or salt thereof to inhibit bacteria from adhering to a submerged surface within the aqueous system. This method effectively controls biofouling without substantially killing the fouling organisms. The amino methyl phosphonic acid used in the methods of the invention has the formula R1R2NCH2P(O)(OH)2. In this formula, R1 and R2 are independently a C6-C20 alkyl group or a CH2P(O)(OH)2 group. However, R1 and R2 are not both a CH2P(O)(OH)2 group. Alternatively, R1 and R2, together with the N, may also form a 5-8 membered heterocyclic ring having the formula: In the heterocyclic ring, X is O, NH, or CH2. The salt of an amino methyl phosphonic acid can be an acid salt or a quaternized amino methyl phosphonic acid salt. The invention also relates to a composition containing amino methyl phosphonic acids or salts thereof and useable in the above methods. The compositions comprise at least one amino methyl phosphonic acid or salt thereof in an amount effective to inhibit bacteria from adhering to submergible or submerged surfaces.
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公开(公告)号：DE69927290D1
公开(公告)日：2005-10-20
申请号：DE69927290
申请日：1999-12-02
Applicant: BUCKMAN LABOR INC
Inventor： DICKINSON H , MCNEEL E , VAN HAUTE EDDIE , CLARK A
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公开(公告)号：DE69927290T2
公开(公告)日：2006-02-02
申请号：DE69927290
申请日：1999-12-02
Applicant: BUCKMAN LABOR INC
Inventor： DICKINSON H , MCNEEL E , VAN HAUTE EDDIE , CLARK A
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公开(公告)号：DE69534714D1
公开(公告)日：2006-02-02
申请号：DE69534714
申请日：1995-01-12
Applicant: BUCKMAN LABOR INC
Inventor： MCNEEL E
Abstract: A method for controlling the chemical treatment of a solution comprises the steps of feeding a treatment chemical into the solution, applying an external voltage across a reference electrode and a working electrode of a voltammetric sensor while the electrodes are immersed in the solution, measuring a current that flows through the working electrode, converting the measured current into a feedback signal indicative of the concentration of treatment chemical in the solution, and using the feedback signal to control the rate of feeding the treatment chemical.
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公开(公告)号：DE69902821T2
公开(公告)日：2003-01-09
申请号：DE69902821
申请日：1999-11-30
Applicant: BUCKMAN LABOR INC
Inventor： HEINDEL D , WHITTEMORE S , GUILLON CHRISTOPHE , RAPP D , LASKIN D , MCNEEL E , HECK E
IPC: C07D493/04 , A61K31/35
Abstract: The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula(V):In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR1R2, or (N+R1R2R3)X-, R1 and R2 are independently a C1-C6 alkyl, or R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring, or when T is (N+R1R2R3)X-, R1 and R2 together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R3 is hydrogen, a C1-C12 alkyl, or, when R1 and R2 together with the nitrogen form a heterocyclic aromatic ring, R3 is a double bond within the heterocyclic aromatic ring; X- is a halide. In another embodiment, the invention relates to processes for preparing 4'-substituted-4',5'-dihydropsoralen compounds described above. The compounds of the invention have beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.
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