公开(公告)号：WO2006119308A2

公开(公告)日：2006-11-09

申请号：PCT/US2006/016874

申请日：2006-05-02

Applicant: BIOSCALE, INC. ,  SAUER-BUDGE, Alexis, F. ,  FITCH, Eric ,  MASTERS, Brett, P. ,  MILLER, Michael ,  LUNDSTROM, Mark

Inventor： SAUER-BUDGE, Alexis, F. ,  FITCH, Eric ,  MASTERS, Brett, P. ,  MILLER, Michael ,  LUNDSTROM, Mark

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: Methods for detecting analytes are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Abstract translation: 提供检测分析物的方法。 将多个颗粒，每个颗粒涂覆有对分析物具有亲和性的捕获剂与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品传送到传感器表面的输送装置，以及可选地构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。

公开(公告)号：WO2004038354A3

公开(公告)日：2004-05-06

申请号：PCT/US2003/026927

申请日：2003-08-28

Applicant: BIOSCALE, INC.

Inventor： CRAWLEY, Ed ,  LUNDSTROM, Mark ,  MASTERS, Brett ,  SRIVASTAVA, Alok ,  SCHMIDT, Martin ,  MILLER, Michael

IPC: H01G5/00

Abstract: The disclosed sensor chip (120) includes a substrate (126) and a moving member (132) coupled to the substrate and disposed for movement relative to the substrate. The moving member (132) moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors (140). The receptors are configured for selectively binding to a first measurement.

公开(公告)号：EP1886142A2

公开(公告)日：2008-02-13

申请号：EP06752113.8

申请日：2006-05-02

Applicant: Bioscale, Inc.

Inventor： SAUER-BUDGE, Alexis, F. ,  FITCH, Eric ,  MASTERS, Brett, P. ,  MILLER, Michael ,  LUNDSTROM, Mark

IPC: G01N33/543

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

Abstract: A system for detecting an analyte in a sample includes a resonant sensor that has a sensor surface coated with the capture agent. A plurality of magnetic particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

公开(公告)号：EP1540677A2

公开(公告)日：2005-06-15

申请号：EP03799821.8

申请日：2003-08-28

Applicant: Bioscale Inc.

Inventor： CRAWLEY, Ed ,  LUNDSTROM, Mark ,  MASTERS, Brett ,  SRIVASTAVA, Alok ,  SCHMIDT, Martin ,  MILLER, Michael

IPC: H01G5/00 ,  H01G7/00

CPC classification number: G01N29/036 ,  B81B3/0089 ,  B81B2201/0214 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01L1/10 ,  G01N2291/0257 ,  G01N2291/0427

Abstract: The disclosed sensor chip (120) includes a substrate (126) and a moving member (132) coupled to the substrate and disposed for movement relative to the substrate. The moving member (132) moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors (140). The receptors are configured for selectively binding to a first measurement.