公开(公告)号：US10125128B2

公开(公告)日：2018-11-13

申请号：US15199100

申请日：2016-06-30

Applicant: Board of Regents, University of Texas System

Inventor： Richard Thomas Lewis ,  Philip Jones ,  Alessia Petrocchi ,  Naphtali Reyna ,  Matthew Hamilton ,  Michael J. Soth ,  Timothy Heffernan ,  Michelle Han ,  Jason P. Burke

IPC: C07D417/14 ,  A61K31/501 ,  A61K45/06 ,  C07D403/14 ,  C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4439

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

公开(公告)号：US20170001996A1

公开(公告)日：2017-01-05

申请号：US15199100

申请日：2016-06-30

Applicant: Board of Regents, University of Texas System

Inventor： Richard Thomas Lewis ,  Philip Jones ,  Alessia Petrocchi ,  Naphtali Reyna ,  Matthew Hamilton ,  Michael J. Soth ,  Timothy Heffernan ,  Michelle Han ,  Jason P. Burke

IPC: C07D417/14 ,  A61K45/06 ,  A61K31/4545 ,  C07D401/14 ,  A61K31/454 ,  A61K31/501 ,  C07D403/14

CPC classification number: C07D417/14 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/501 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  A61K2300/00

Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract translation: 还提供了抑制人或动物受试者的GLS1活性的方法。