公开(公告)号：US20240325108A1

公开(公告)日：2024-10-03

申请号：US18194007

申请日：2023-03-31

Applicant: C.R. Bard, Inc.

Inventor： Aaron Blank ,  Hiep Q. Do

IPC: A61B90/00 ,  A61L31/04 ,  A61L31/14

CPC classification number: A61B90/39 ,  A61L31/041 ,  A61L31/145 ,  A61L31/146 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3995 ,  A61L2300/802 ,  A61L2400/04 ,  A61L2420/02

Abstract: A tissue marker is provided having a permanent portion and a biodegradable portion. The permanent portion includes a material detectable by an imaging modality. The biodegradable portion surrounds the permanent portion. The biodegradable portion includes a polymer body, a coating, and a plurality of distinct structures dispersed in the polymer body. The coating covers an outer surface of the polymer body. Each of the distinct structures include an outer shell designed to open upon the application of focused ultrasound to release a therapeutic agent within the outer shell into the polymer body. Therapeutic agents may be introduced into the biodegradable portion of the tissue marker after a period of time after introduction of the tissue marker into the tissue. In addition, methods of fabricating a three-layer tissue marker are provided.