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    APPARATUS FOR STABILIZING MECHANICAL, THERMAL, AND OPTICAL PROPERTIES AND FOR REDUCING THE FLUORESCENCE OF BIOLOGICAL SAMPLES FOR OPTICAL EVALUATION
    3.
    发明申请
    APPARATUS FOR STABILIZING MECHANICAL, THERMAL, AND OPTICAL PROPERTIES AND FOR REDUCING THE FLUORESCENCE OF BIOLOGICAL SAMPLES FOR OPTICAL EVALUATION 审中-公开
    用于稳定机械，热和光学性质并降低生物样品荧光的光学评估的装置

    公开(公告)号：WO2012173686A1

    公开(公告)日：2012-12-20

    申请号：PCT/US2012/032823

    申请日：2012-04-09

    Applicant: C8 MEDISENSORS INC. ,  LIPSON, Jan ,  BERNHARDT, Jeffrey, M. ,  MCNAMARA, Robert, P. ,  HOFMEISTER, Rudolf, J. ,  ICE, Donald, A.

    Inventor： LIPSON, Jan ,  BERNHARDT, Jeffrey, M. ,  MCNAMARA, Robert, P. ,  HOFMEISTER, Rudolf, J. ,  ICE, Donald, A.

    IPC: G01N21/01

    CPC classification number: G01N21/01

    Abstract: An apparatus is presented for stabilizing an optical, thermal, and mechanical interface between a spectroscopic and/or imaging system and a biological sample. The apparatus includes a window retainer having a retainer surface and a well. The retainer surface surrounds the well. Further, the retainer surface is substantially planar. An optical window is located in the well. The optical window comprises a first and second surface. The second surface is in contact with the window retainer. The first surface is substantially flush with the retainer surface. The apparatus further includes an attachment mechanism coupling the window retainer to the biological sample such that a fluid, gel, adhesive or elastomer interposed between the optical window and the biological sample is trapped in the well.

    Abstract translation: 提出了用于稳定光谱和/或成像系统与生物样品之间的光学，热学和机械界面的装置。 该装置包括具有保持器表面和井的窗口保持器。 保持器表面围绕井。 此外，保持器表面基本上是平面的。 光学窗口位于井中。 光学窗口包括第一和第二表面。 第二表面与窗口保持器接触。 第一表面与保持器表面基本齐平。 该装置还包括将窗口保持器联接到生物样本的附接机构，使得插入光学窗口和生物样品之间的流体，凝胶，粘合剂或弹性体被捕获在孔中。

    APPARATUS FOR INCREASING BLOOD PERFUSION AND IMPROVING HEAT SINKING TO SKIN
    4.
    发明申请
    APPARATUS FOR INCREASING BLOOD PERFUSION AND IMPROVING HEAT SINKING TO SKIN 审中-公开
    用于增加血液灌注并改善对皮肤的热吸收的装置

    公开(公告)号：WO2010141262A1

    公开(公告)日：2010-12-09

    申请号：PCT/US2010/036026

    申请日：2010-05-25

    Applicant: C8 MEDISENSORS INC. ,  ICE, Donald, A. ,  HOFMEISTER, Rudolf, J. ,  BLOCK, Ueyn, L. ,  LIPSON, Jan

    Inventor： ICE, Donald, A. ,  HOFMEISTER, Rudolf, J. ,  BLOCK, Ueyn, L. ,  LIPSON, Jan

    IPC: A61F7/00

    CPC classification number: A61B5/14532 ,  A61B5/0066 ,  A61B5/024 ,  A61B5/026 ,  A61B5/1455 ,  A61B5/1491

    Abstract: An apparatus for increasing the blood perfusion in skin by elevating the temperature, and for providing superior heat sinking to the skin of thermally dissipative devices is disclosed. The increased perfusion gives rise to improved thermal transport properties near the site of elevated temperature which is advantageously used by thermally connecting the dissipative devices to the skin. The heat generated by the thermally dissipative devices can supplement or replace separate heating elements to elevate the skin temperature. Alternatively, thermal isolation of the heated area of the skin from the heat sinks of the dissipative devices can minimize the temperature of the skin in contact with the heat sinks.

    Abstract translation: 公开了一种用于通过升高温度来增加皮肤中的血液灌注并且为散热装置的皮肤提供优异的散热的装置。 增加的灌注在高温部位附近产生改善的热传递性质，这有利地通过将消散装置热连接到皮肤上来使用。 由热耗散装置产生的热量可补充或代替单独的加热元件以提升皮肤温度。 或者，将散热装置的散热片的加热区域热隔离可以使与散热器接触的皮肤的温度最小化。

    SYSTEMS HAVING A REFLECTED LIGHT SENSOR AND METHODS OF USE
    5.
    发明申请
    SYSTEMS HAVING A REFLECTED LIGHT SENSOR AND METHODS OF USE 审中-公开
    具有反射光传感器的系统及其使用方法

    公开(公告)号：WO2013173237A1

    公开(公告)日：2013-11-21

    申请号：PCT/US2013/040794

    申请日：2013-05-13

    Applicant: C8 MEDISENSORS INC.

    Inventor： LIPSON, Jan ,  ICE, Donald, A. ,  HOFMEISTER, Rudolf, J. ,  ZHOU, Yuxin ,  SAMPSON, Harold, G. ,  HUANG, Qingfeng ,  STEWART, James

    IPC: G01J3/02

    CPC classification number: G01J3/021 ,  G01J1/32 ,  G01J3/0297 ,  G01J3/10 ,  H01L27/14601 ,  H01L27/14806

    Abstract: Various systems and methods of monitoring laser safety by sensing contact of the system with a sample are provided. The system includes a focusing element for focusing an incident light from a laser light source onto a sample, an optical element having a collection zone for collecting a signal from the sample, a reflected light sensor for sensing a reflected light from the sample, wherein the reflected light sensor is located outside the collection zone of the optical element and on an inner surface of a housing of the system, an electrical circuit operably connected to the reflected light sensor and the laser light source and configured to control power to the laser light source in accordance with the reflected light sensed by the reflected light sensor and a spectral analyzer for processing the signal. Methods and other systems are also described and illustrated.

    Abstract translation: 提供了通过感测系统与样品的接触来监测激光器安全性的各种系统和方法。 该系统包括用于将来自激光源的入射光聚焦到样本上的聚焦元件，具有用于收集来自样品的信号的收集区域的光学元件，用于感测来自样品的反射光的反射光传感器，其中， 反射光传感器位于光学元件的收集区域的外部并且位于系统的壳体的内表面上，可操作地连接到反射光传感器和激光源并被配置为控制激光源的功率的电路 根据由反射光传感器感测的反射光和用于处理信号的光谱分析器。 还描述和示出了方法和其他系统。

    CALIBRATED ANALYTE CONCENTRATION MEASUREMENTS IN MIXTURES
    6.
    发明申请
    CALIBRATED ANALYTE CONCENTRATION MEASUREMENTS IN MIXTURES 审中-公开
    混合分析仪分析仪的浓度测定

    公开(公告)号：WO2009038908A1

    公开(公告)日：2009-03-26

    申请号：PCT/US2008/073045

    申请日：2008-08-13

    Applicant: C8 MEDISENSORS INC. ,  LIPSON, Jan ,  LENOSKY, Thomas, J. ,  BERNHARDT, Jeffrey, M.

    Inventor： LIPSON, Jan ,  LENOSKY, Thomas, J. ,  BERNHARDT, Jeffrey, M.

    IPC: A61B5/145

    CPC classification number: A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/441 ,  A61B5/4839 ,  A61B5/7232 ,  G01N21/65

    Abstract: The concentration of analytes in a complex mixture can be ascertained by spectroscopic measurement, even if the spectra of substances other than the analyte overlap with that of the analyte. Both independently measured concentrations of the analyte in a training set and of the analyte spectrum are used. Variances in the spectral data attributable to the analyte are isolated from spectral variances from other causes, such as compositional changes associated with different samples that are independent of the analyte. For the special case of noninvasive glucose measurements on the skin of biological organisms, the volume averaged glucose in the sample is predicted from the blood glucose. A test for over-fitting of the data is also described.

    Abstract translation: 通过光谱测量可以确定复杂混合物中分析物的浓度，即使分析物以外的物质的光谱与分析物的光谱重叠。 使用训练集和分析物光谱中分析物的独立测量浓度。 归因于分析物的光谱数据的差异与其他原因的光谱变化隔离，例如与独立于分析物的不同样品相关的组成变化。 对于在生物体的皮肤上进行非侵入性葡萄糖测量的特殊情况，从血糖预测样品中的体积平均葡萄糖。 还描述了用于过拟合数据的测试。

    ALL REFLECTIVE APPARATUS FOR INJECTING EXCITATION LIGHT AND COLLECTING IN-ELASTICALLY SCATTERED LIGHT FROM A SAMPLE
    7.
    发明申请
    ALL REFLECTIVE APPARATUS FOR INJECTING EXCITATION LIGHT AND COLLECTING IN-ELASTICALLY SCATTERED LIGHT FROM A SAMPLE 审中-公开
    用于注射激光的所有反射装置和从样品中收集非弹性散射光

    公开(公告)号：WO2010141258A1

    公开(公告)日：2010-12-09

    申请号：PCT/US2010/035967

    申请日：2010-05-24

    Applicant: C8 MEDISENSORS INC. ,  LIPSON, Jan ,  ICE, Donald, A.

    Inventor： LIPSON, Jan ,  ICE, Donald, A.

    IPC: G01J3/44

    CPC classification number: G01J3/4412 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J2003/1226 ,  G01J2003/1247

    Abstract: An apparatus is disclosed wherein laser radiation illuminates a sample using all reflective optics and wherein in-elastically scattered light from the sample is collected using the identical elements. The apparatus obviates the problem of contaminating the laser radiation with unwanted spectra from transmissive optics while providing very high rejection of the laser radiation with respect to the in-elastically scattered light. In addition, the apparatus can collect and launch light with high numerical aperture and large field of view.

    Abstract translation: 公开了一种装置，其中激光辐射使用所有反射光学器件照射样品，并且其中使用相同的元件收集来自样品的弹性散射光。 该装置消除了从透射光学器件引起的不需要的光谱污染激光辐射的问题，同时相对于弹性散射光提供了对激光辐射的非常高的抑制。 另外，该装置可以收集和发射具有高数值孔径和大视场的光。

    ENHANCING SELECTIVITY AND/OR SENSITIVITY OF SPECTROSCOPIC MEASUREMENTS IN MEDIA
    9.
    发明申请
    ENHANCING SELECTIVITY AND/OR SENSITIVITY OF SPECTROSCOPIC MEASUREMENTS IN MEDIA 审中-公开
    提高媒体中光谱测量的选择性和/或灵敏度

    公开(公告)号：WO2007127909A2

    公开(公告)日：2007-11-08

    申请号：PCT/US2007/067608

    申请日：2007-04-27

    Applicant: C8 MEDISENSORS INC. ,  LIPSON, Jan ,  LIPSON, Albert, L. ,  MCNAMARA, Robert, P.

    Inventor： LIPSON, Jan ,  LIPSON, Albert, L. ,  MCNAMARA, Robert, P.

    IPC: G01J3/00

    CPC classification number: G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0289 ,  G01N21/4738 ,  G01N2021/4709 ,  G01N2021/4747 ,  G01N2021/656 ,  G01N2201/124

    Abstract: An apparatus for enhancing the selectivity for spectroscopic measurements of analytes in a turbid medium is described. In one example, spatial filters are used to select only certain radii from the medium to be imaged. This selection is accomplished by placing an optical obstruction on the surface of the medium or at an image plane of the surface later in the optical imaging system. In one implementation, this is achieved by placing a fiber bundle at an image plane of the collecting optical system and then using a spacer of appropriate size at the center of the fiber bundle to act as a central obstruction.

    Abstract translation: 描述了用于提高浑浊介质中分析物的光谱测量的选择性的装置。 在一个示例中，空间滤波器用于仅从要成像的介质中选择某些半径。 该选择通过在光学成像系统中稍后将光学障碍物放置在介质的表面或表面的像平面上来实现。 在一个实施方案中，这是通过将纤维束放置在收集光学系统的图像平面上，然后在纤维束的中心使用适当尺寸的间隔件来作为中心障碍物来实现的。

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