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Patent Agency Ranking
公开(公告)号：WO2016123157A9
公开(公告)日：2016-10-20
申请号：PCT/US2016015002
申请日：2016-01-26
Applicant: CALIFORNIA INST OF TECHN
Inventor： KIM JINHO , YANG CHANGHUEI
CPC classification number: G02B21/365 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G01N2021/6478 , G01N2201/0446 , G02B21/0076 , G02B21/16 , H04N5/2258
Abstract: An imaging device for bright field Fourier ptychographic imaging and fluorescence imaging comprises a first fluorescence illumination source configured to provide excitation light of a first range of wavelengths to a transparent well; an optical system having a pair of objectives positioned oppositely; and an image sensor configured to receive light propagated through the optical system from the transparent well. The image sensor is configured to acquire a sequence of uniquely illuminated intensity measurements of light passing through a sample in the well based on sequential illumination at different illumination angles from a variable illumination source, and further configured to acquire a first fluorescence image of the sample based on light emitted by the sample in response to excitation light of the first range of wavelengths.
Abstract translation: 一种用于明场傅立叶谱图成像和荧光成像的成像装置，包括：第一荧光照明源，被配置为向第一透明阱提供第一波长范围的激发光; 具有相对定位的一对物镜的光学系统; 以及图像传感器，被配置为从所述透明孔接收通过所述光学系统传播的光。 图像传感器被配置为基于来自可变照明源的不同照明角度的顺序照明来获取穿过井中的样本的光的唯一照明强度测量序列，并且还被配置为获取基于样本的第一荧光图像 对由样品响应于第一波长范围的激发光而发射的光。
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公开(公告)号：AU2016211635A1
公开(公告)日：2017-06-29
申请号：AU2016211635
申请日：2016-01-26
Applicant: CALIFORNIA INST OF TECHN
Inventor： KIM JINHO , YANG CHANGHUEI
Abstract: An imaging device for bright field Fourier ptychographic imaging and fluorescence imaging comprises a first fluorescence illumination source configured to provide excitation light of a first range of wavelengths to a transparent well; an optical system having a pair of objectives positioned oppositely; and an image sensor configured to receive light propagated through the optical system from the transparent well. The image sensor is configured to acquire a sequence of uniquely illuminated intensity measurements of light passing through a sample in the well based on sequential illumination at different illumination angles from a variable illumination source, and further configured to acquire a first fluorescence image of the sample based on light emitted by the sample in response to excitation light of the first range of wavelengths.
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公开(公告)号：AU2016211634A1
公开(公告)日：2017-05-04
申请号：AU2016211634
申请日：2016-01-26
Applicant: CALIFORNIA INST OF TECHN
Inventor： KIM JINHO , YANG CHANGHUEI
Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.
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公开(公告)号：CA2970053A1
公开(公告)日：2016-08-04
申请号：CA2970053
申请日：2016-01-26
Applicant: CALIFORNIA INST OF TECHN
Inventor： KIM JINHO , YANG CHANGHUEI
Abstract: An imaging device for bright field Fourier ptychographic imaging and fluorescence imaging comprises a first fluorescence illumination source configured to provide excitation light of a first range of wavelengths to a transparent well; an optical system having a pair of objectives positioned oppositely; and an image sensor configured to receive light propagated through the optical system from the transparent well. The image sensor is configured to acquire a sequence of uniquely illuminated intensity measurements of light passing through a sample in the well based on sequential illumination at different illumination angles from a variable illumination source, and further configured to acquire a first fluorescence image of the sample based on light emitted by the sample in response to excitation light of the first range of wavelengths.
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公开(公告)号：CA2965999A1
公开(公告)日：2016-08-04
申请号：CA2965999
申请日：2016-01-26
Applicant: CALIFORNIA INST OF TECHN
Inventor： KIM JINHO , YANG CHANGHUEI
Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.
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