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    LIGHT FILTER AND SENSOR
    1.
    发明申请
    LIGHT FILTER AND SENSOR 审中-公开
    滤光片和传感器

    公开(公告)号：WO2018029014A1

    公开(公告)日：2018-02-15

    申请号：PCT/EP2017/069161

    申请日：2017-07-28

    Applicant: CAMBRIDGE DISPLAY TECHNOLOGY LIMITED ,  SUMITOMO CHEMICAL COMPANY LIMITED

    Inventor： BURROUGHES, Jeremy ,  LEE, Andrew ,  BEHRENDT, Jonathan

    IPC: G01N21/64 ,  G02B5/22

    Abstract: A sensor comprising a light source (103); a photodetector (105); a sample receptacle such as a microfluidic device (101) between the light source and the photodetector; and one or both of a first light filter (107) and a second light filter (109) wherein the first light filter is provided between the sample receptacle and the photodetector and the second light filter is provided between the sample receptacle and the light source. The first light filter may comprise tartrazine. The second light filter may comprise Coomassie violet R200, Victoria Blue B or acid fuchsin. In use, light hν1 emitted from the light source is absorbed by a luminescent indicator in the sample receptacle which then emits light hν2 detected by the photodetector.

    Abstract translation: 一种包括光源（103）的传感器; 一个光电探测器（105）; 在光源和光电检测器之间的样品容器，例如微流体装置（101） 以及第一滤光器（107）和第二滤光器（109）中的一个或两个，其中第一滤光器设置在样品容器和光电检测器之间，并且第二滤光器设置在样品容器和光源之间。 第一滤光器可以包含酒石黄。 第二滤光器可以包括考马斯紫R200，维多利亚蓝B或酸性品红。 在使用中，从光源发出的光hν1被样品容器中的发光指示器吸收，然后发出由光电检测器检测到的光hν2。

    ENZYME LINKED ASSAY METHODS AND APPARATUSES
    2.
    发明申请
    ENZYME LINKED ASSAY METHODS AND APPARATUSES 审中-公开

    公开(公告)号：WO2020193934A1

    公开(公告)日：2020-10-01

    申请号：PCT/GB2020/050267

    申请日：2020-02-06

    Applicant: SUMITOMO CHEMICAL COMPANY LIMITED ,  CAMBRIDGE DISPLAY TECHNOLOGY LIMITED

    Inventor： LEE, Andrew

    IPC: G01N33/543 ,  B01L3/00 ,  G01N21/63 ,  G01N33/58

    Abstract: A method of measuring a concentration of a target analyte (17) using an enzyme linked assay is described. The enzyme linked assay is conducted using a fluidic device (1) including one or more flow cells (2). Each flow cell (2) includes a channel (7) and at least two ports (8a, 8b) in fluid communication with the channel (7). At least one internal surface (9) of each channel (7) is functionalised with a capture molecule (10) which enables functionalising the flow cell (2) using an enzyme linked assay applied to a sample (12). The capture molecules will immobilise complexes of enzyme molecules bound to target analyte. The fluidic device (1) also includes a photodiode (3) corresponding to each flow cell (2) and arranged to receive light (11) from the corresponding flow cell (2). Each photodiode (3) is attached to the corresponding flow cell (2) or each photodiode (3) is integrally formed with the corresponding flow cell (2). The method includes, for a flow cell (2) of the fluidic device (1), functionalising the flow cell (2) using an enzyme linked assay applied to a sample (12), such that in response to the sample (12) contains the target analyte (17), the flow cell (2) will become functionalised with an immobilised concentration (21) of enzyme molecules (15) bound to the target analyte (21). The method also includes, for each flow cell (2), introducing a substrate (23) to the flow cell. The substrate (23) is convertible into a reporting substance (24) by the enzyme molecules (15). The method also includes recording, using the photodiode (3) corresponding to the flow cell (2), a time series (3) of measured values corresponding to an optical property of the flow cell (2) which depends on a concentration of the reporting substance (24). The method also includes determining a first time point (t 1 ) corresponding to the introduction of the substrate (23) to the flow cell (2). The method also includes determining a second time point (t 2 ) corresponding to an endpoint of linear kinetics for the conversion of substrate (23) into reporting substance (24). The method also includes estimating, based on the measured values obtained between the first and second time points (t 1 , t 2 ), a concentration of the target analyte (17) in the sample.

    ORGANIC-BASED FLUORESCENCE SENSOR WITH LOW BACKGROUND SIGNAL
    3.
    发明申请
    ORGANIC-BASED FLUORESCENCE SENSOR WITH LOW BACKGROUND SIGNAL 审中-公开
    具有低背景信号的有机体荧光传感器

    公开(公告)号：WO2017055437A1

    公开(公告)日：2017-04-06

    申请号：PCT/EP2016/073241

    申请日：2016-09-29

    Applicant: CAMBRIDGE DISPLAY TECHNOLOGY LIMITED

    Inventor： BURROUGHES, Jeremy ,  WILSON, Richard ,  LEE, Andrew

    IPC: G01N21/64

    CPC classification number: G01N21/645 ,  G01N2201/0628

    Abstract: Fluorescence-based sensors having favourably low detection limits and high sensitivity are disclosed. The sensors comprise one or more solution processable colour filters that are used together with organic LEDs and photodiodes. The colour filters are used to narrow the wavelength range of the OLED emission and/or to reject any light from reaching the photodiode which is not from analyte fluorescence, thereby enhancing the device sensitivity.

    Abstract translation: 公开了具有良好的检测极限和高灵敏度的基于荧光的传感器。 这些传感器包括与有机LED和光电二极管一起使用的一个或多个可解决处理的滤色器。 滤色器用于缩小OLED发射的波长范围和/或抑制任何光到达不是来自分析物荧光的光电二极管，从而提高器件灵敏度。

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