公开(公告)号：WO1997037607A3

公开(公告)日：1997-10-16

申请号：PCT/US1997005714

申请日：1997-04-08

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  SCHAER, Alan, K.

IPC: A61B17/39

Abstract: An intravascular device for the formation of linear lesions which has particular utility in the treatment of atrial fibrillation and flutter. The intravascular device has an outer delivery sheath (11) with a distal section (25) which has an elongated opening (28) and a support member (26) coextending with the opening (28). An EP device (12) having a plurality of electrodes (32) on its distal portion (31) is slidably disposed within the inner lumen (13) of the delivery sheath (11) but it is secured by its distal end within the distal extremity of the delivery sheath (11) at least while in operation. In this manner an axial force in the distal direction on the proximal extremity of the EP device (12), which extends out of the patient during the procedure, will cause the distal portion of the EP device (12) to arch outwardly out of and away from the distal section (25) of the delivery sheath (11) and engage the surface of the patient's heart chamber. High frequency, e.g. RF, electrical energy delivered to the electrodes (32) on the distal shaft section (31) of the EP device (12) will form a linear lesion which terminates the fibrillation or flutter.

公开(公告)号：WO1998006451A1

公开(公告)日：1998-02-19

申请号：PCT/US1997014071

申请日：1997-08-11

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  MORLEY, Tracey, A. ,  WANG, Paul, J.

IPC: A61M25/10

CPC classification number: A61M25/104 ,  A61B18/02 ,  A61B18/06 ,  A61B2017/22038 ,  A61B2017/22067 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61M25/10 ,  A61M2025/1079 ,  A61M2025/1093 ,  A61N2001/0585

Abstract: A method and system for lysing a patient's heart tissue causing or involved with arrhythmia which includes an intravascular catheter with a relatively inelastic occlusion balloon on the distal end of the catheter which is inflated to block an artery or vein of the patient's heart so than when lysing fluid such as an ethanol solution is discharged from the distal port in the catheter the inflated balloon prevents the proximal refluxing of lysing medium into undesirable areas of the patient's heart. The inelastic balloon is configured to be inflated to a diameter of about 0.7 to about 1.3, preferably about 0.8 to about 1.2, times the diameter of the blood vessel in which the balloon is to be inflated so as to effectively occlude the passageway without damaging the wall of the blood vessel. The working length of the balloon is less than about 1.5 cm, preferably less than 0.75 cm.

Abstract translation: 一种用于裂解引起或参与心律失常的患者心脏组织的方法和系统，其包括在导管的远端上具有相对非弹性闭塞气囊的血管内导管，其被充气以阻塞患者心脏的动脉或静脉，而不是在裂解时 诸如乙醇溶液的流体从导管中的远端口排出，充气气球防止裂解介质的近端回流进入患者心脏的不期望的区域。 非弹性球囊被构造成充气至球囊膨胀的血管的直径的约0.7至约1.3，优选约0.8至约1.2倍的直径，以便有效地闭塞通道而不损伤 血管壁。 球囊的工作长度小于约1.5厘米，优选小于0.75厘米。

公开(公告)号：WO1996040342A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009283

申请日：1996-06-05

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  RANDOLPH, Yvonne ,  DICKENS, Duane

IPC: A61M25/00

CPC classification number: A61M29/02 ,  A61B18/1492 ,  A61M25/0041 ,  A61M25/0054 ,  A61M25/0141 ,  A61M25/0152 ,  A61M25/0662 ,  A61M2025/0081 ,  A61M2025/1052 ,  A61M2210/125 ,  A61N1/056 ,  A61N1/057

Abstract: A guiding catheter for delivery of intravascular devices to a patient's coronary sinus. The guiding catheter has a relatively stiff proximal section and a relatively flexible distal section, the latter being about 1 to about 6 inches in length and being configured to subselect a branch cardiac vein leading to the coronary sinus. The guiding catheter is particularly suitable for delivering an intravascular device for sensing electrical activity into a cardiac vein to detect such activity from within the blood vessel.

Abstract translation: 用于将血管内装置输送到患者的冠状窦的引导导管。 引导导管具有相对刚性的近端部分和相对柔性的远端部分，后端部分的长度为约1至约6英寸，并且构造成分选通向冠状窦的分支心静脉。 引导导管特别适用于将用于感测电活动的血管内装置输送到心静脉以从血管内检测这种活动。

公开(公告)号：WO1995024160A1

公开(公告)日：1995-09-14

申请号：PCT/US1995002593

申请日：1995-03-03

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  DICKENS, Duane ,  SAMSON, Gene ,  SUNG, Ruey

IPC: A61B17/39

CPC classification number: A61B18/1492 ,  A61B2017/00084 ,  A61B2017/22051 ,  A61B2018/00285 ,  A61B2018/00386 ,  A61B2018/00434

Abstract: The invention is directed to an intravascular device for occluding a patient's blood vessel by coagulating blood in a desired location within the blood vessel to form occluding thrombus therein by means of RF electrical energy which preferably has a frequency of about 0.3 to about 1.5 megahertz. The intravascular device is particularly useful in terminating arrhythmia in a patient's heart by occluding a coronary artery to terminate the flow of oxygenated blood to a region of the patient's heart where aberrant signals causing the arrhythmia either originate or through which they are conducted. The device may also be used to occlude other blood vessels such as in the treatment of intracranial berry aneurysms.

Abstract translation: 本发明涉及血管内装置，其用于通过使血液凝结在血管内的期望位置以阻塞患者的血管，以通过优选具有约0.3至约1.5兆赫的频率的RF电能在其中形成闭塞性血栓。 血管内装置特别可用于通过闭塞冠状动脉来终止患者心脏中的心律失常，以终止氧化血液流向患者心脏的区域，其中导致心律失常的异常信号源于或通过它们进行。 该装置还可用于封闭其他血管，例如治疗颅内浆液动脉瘤。

公开(公告)号：WO1994016618A1

公开(公告)日：1994-08-04

申请号：PCT/US1994001054

申请日：1994-01-28

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  LITTMAN, Laszlo ,  SAMSON, Gene ,  VEGH, Gabriel, B.

IPC: A61B05/042

CPC classification number: A61B17/12022 ,  A61B5/02007 ,  A61B5/0422 ,  A61B5/6852 ,  A61B17/12109 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12163 ,  A61B17/22012 ,  A61B18/14 ,  A61B2017/00022 ,  A61B2017/00026 ,  A61B2017/00243 ,  A61B2017/1205 ,  A61B2017/12063 ,  A61B2562/0209 ,  A61B2562/043

Abstract: A system for detecting electrical activity within a patient's heart comprising an elongated intravascular device (10), such as a catheter or guidewire, having at least one bipolar electrode pair (17, 18) on a distal section (12) of the elongated device to intravascularly detect electrical activity within the patient's heart. The catheter or guidewire preferably has a tubular shaft (14) formed of braided strands which include a plurality of insulated conductors (15) which are electrically connected to the bipolar electrodes (17, 18).

Abstract translation: 一种用于检测患者心脏内的电活动的系统，包括细长的血管内装置（10），例如导管或导丝，其具有在细长装置的远端部分（12）上的至少一个双极电极对（17,18） 血管内检测患者心脏内的电活动。 导管或导丝线优选地具有由编织股形成的管状轴（14），其包括电连接到双极电极（17,18）的多个绝缘导体（15）。

公开(公告)号：WO1996037146A1

公开(公告)日：1996-11-28

申请号：PCT/US1996006636

申请日：1996-05-08

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  SCHAER, Alan, K.

IPC: A61B05/042

CPC classification number: A61B5/6853 ,  A61B5/0422 ,  A61B18/1492 ,  A61B2017/22038 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/0016 ,  A61B2018/00232 ,  A61B2018/00285 ,  A61B2018/00357 ,  A61B2018/00386 ,  A61B2018/00577 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/1253 ,  A61B2018/1437 ,  A61B2218/002 ,  A61B2562/0209 ,  A61B2562/043

Abstract: An over-the-wire electrophysiology catheter which has an emitting electrode on the distal tip electrically connected to a source of high frequency electrical energy. The intravascular device is configured to be advanced through a patient's cardiac veins or coronary arteries and preferably is also provided with sensing electrodes for detecting electrical activity of the patient's heart from within a blood vessel of the heart. The device forms large lesions in tissue adjacent to the blood vessel in which the device is located without significantly damaging the blood vessel to effectively terminate signals causing arrhythmia.

Abstract translation: 一种线上电生理学导管，其在远端上具有电连接到高频电能源的发射电极。 血管内装置被构造成通过患者的心脏静脉或冠状动脉前进，并且优选还设置有感测电极，用于从心脏的血管内检测患者心脏的电活动。 该装置在与设备所在的血管相邻的组织中形成大的损伤，而不会明显损伤血管，以有效地终止引起心律失常的信号。

公开(公告)号：WO1996036277A1

公开(公告)日：1996-11-21

申请号：PCT/US1996006631

申请日：1996-05-08

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  LITTMANN, Laszlo ,  LAU, Liming ,  AMIRANA, Omar

IPC: A61B05/042

CPC classification number: A61B17/12022 ,  A61B5/0422 ,  A61B17/22012 ,  A61B18/14 ,  A61B2017/00022 ,  A61B2017/00026 ,  A61B2017/00243 ,  A61B2562/0209 ,  A61B2562/043

Abstract: A system for detecting electrical activity within a patient's heart comprising an elongated intravascular device (10), such as a catheter or guidewire, having a plurality of sensing electrodes (16) on a distal section of the elongated device to detect electrical activity from within a blood vessel of the patient's heart. The intravascular device has a first compact array (17) with a relatively small interelectrode spacing, such as less than 2 mm, and may have a second electrode array (20) with an interelectrode spacing much greater than the interelectrode spacing in the first array. The second electrode array may be used to detect the general region of the arrhythmogenic tissue and the first electrode array is used to provide a high resolution of the electrical detection to more accurately pinpoint the location of the arrhythmogenic site. When the general region of the arrhythmogenic focus is known, an intravascular device having a single array of electrodes with an interelectrode spacing of less than 2 mm may be used.

Abstract translation: 一种用于检测患者心脏内的电活动的系统，包括细长的血管内装置（10），例如导管或导丝，其具有在细长装置的远端部分上的多个感测电极（16），以检测电活动 患者心脏的血管 血管内装置具有第一紧凑阵列（17），其具有相对小的电极间间隔，例如小于2mm，并且可以具有第二电极阵列（20），其间的电极间距远远大于第一阵列中的电极间间隔。 第二电极阵列可用于检测致心律失常组织的一般区域，并且第一电极阵列用于提供电检测的高分辨率以更精确地确定致心律失常部位的位置。 当已知致心律失常焦点的一般区域时，可以使用具有电极间距小于2mm的单个电极阵列的血管内装置。

公开(公告)号：WO1995031243A1

公开(公告)日：1995-11-23

申请号：PCT/US1995006189

申请日：1995-05-11

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  SCHAER, Alan, K. ,  DICKENS, Duane

IPC: A61M25/01

CPC classification number: A61M25/0144 ,  A61M25/0147 ,  A61M2025/0161

Abstract: An electrophysiology catheter assembly having a deflection mechanism rotatably disposed within an inner lumen of the catheter so that deflection of the deflection mechanism within the inner lumen results in a deflection of the distal portion of the catheter. Rotation of the deflection mechanism within the inner lumen of the catheter allows universal deflection of the distal portion of the catheter about its longitudinal axis. The deflection mechanism may be first rotated and then deflected or it may be first deflected and then rotated in a deflected condition. The catheter shaft does not need to be rotated to change the shape of its distal portion.

Abstract translation: 一种电生理学导管组件，其具有可旋转地设置在导管的内腔内的偏转机构，使得偏转机构在内腔内的偏转导致导管的远端部分的偏转。 导管的内腔内的偏转机构的旋转允许导管的远侧部分绕其纵向轴线的万能偏转。 偏转机构可以首先旋转然后被偏转，或者可以首先偏转，然后在偏转状态下旋转。 导管轴不需要旋转以改变其远侧部分的形状。

公开(公告)号：WO1994016632A1

公开(公告)日：1994-08-04

申请号：PCT/US1994001018

申请日：1994-01-28

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  SUNG, Ruey ,  SAMSON, Gene

IPC: A61B17/12

CPC classification number: A61B17/12022 ,  A61B5/02007 ,  A61B5/0422 ,  A61B5/6852 ,  A61B17/12109 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12163 ,  A61B17/22012 ,  A61B18/14 ,  A61B2017/00022 ,  A61B2017/00026 ,  A61B2017/00243 ,  A61B2017/1205 ,  A61B2017/12063 ,  A61B2562/0209 ,  A61B2562/043

Abstract: A method and system for treating a patient's heart exhibiting arrhythmia by first detecting electrical activity within the patient's heart to determine the location of the arrhythmogenic site or conductive pathway causing the arrhythmia and then creating an infarct within the region of the patient's heart where the arrhythmogenic site or the conductive pathway causing the arrhythmia is located by delivering an occluding element to a coronary artery which delivers oxygenated blood to said region of the patient's heart. In one presently preferred embodiment the occluding element is a flaccid or limp coil which when disposed in a coronary arterial passageway forms a randomly shaped, intertwined mass which quickly forms thrombus within the coronary artery to block the passage of oxygenated blood therethrough. The flaccid coil may be delivered through an inner lumen of a catheter which has a distal portion extending within the coronary artery.

Abstract translation: 一种用于通过首先检测患者心脏内的电活动来确定患者心脏的心律失常的方法和系统，以确定导致心律不齐的致心律失常部位或导电途径的位置，然后在患者心脏的区域内产生梗死，其中心律失调部位 或通过将阻塞元件递送到将氧合血液递送到患者心脏的所述区域的冠状动脉来定位引起心律失常的导电通路。 在一个目前优选的实施方案中，阻塞元件是松弛或跛行线圈，其当设置在冠状动脉通路中时形成随机形状的缠结质量块，其在冠状动脉内快速形成血栓以阻止氧合血液通过其中。 松弛线圈可以通过导管的内腔输送，其具有在冠状动脉内延伸的远侧部分。

公开(公告)号：WO1994016619A1

公开(公告)日：1994-08-04

申请号：PCT/US1994001055

申请日：1994-01-28

Applicant: CARDIMA, INC.

Inventor： CARDIMA, INC. ,  LITTMAN, Laszlo ,  DICKENS, Duane

IPC: A61B05/042

CPC classification number: A61B17/12022 ,  A61B5/02007 ,  A61B5/0422 ,  A61B5/6852 ,  A61B17/12109 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12163 ,  A61B17/22012 ,  A61B18/14 ,  A61B2017/00022 ,  A61B2017/00026 ,  A61B2017/00243 ,  A61B2017/1205 ,  A61B2017/12063 ,  A61B2562/0209 ,  A61B2562/043

Abstract: A method and system for detecting electrical activity within a patient's heart, particularly the electrical activity which causes arrhythmia, which includes a first intravascular device (40) such as a catheter or guidewire having a plurality of sensing electrodes (15) on a distal portion (14) thereof which is disposed within one location of the patient's coronary vasculature and a second intravascular device (11) such as a catheter or guidewire having a plurality of sensing electrodes (17) on a distal portion (16) thereof which is disposed within a second location of the patient's coronary vasculature to facilitate mapping the electrical activity of the patient's heart. Once the electrical activity has been mapped, therapeutic procedures can be initiated.

Abstract translation: 一种用于检测患者心脏内的电活动的方法和系统，特别是导致心律失常的电活动，其包括第一血管内装置（40），例如在远侧部分上具有多个感测电极（15）的导管或导丝（ 其设置在患者的冠状动脉脉管系统的一个位置内，以及第二血管内装置（11），例如导管或导丝，其在远侧部分（16）上具有多个感测电极（17） 患者冠状动脉脉管系统的第二位置以便于映射患者心脏的电活动。 一旦映射了电活动，就可以启动治疗程序。