公开(公告)号：WO1995026678A1

公开(公告)日：1995-10-12

申请号：PCT/US1994014865

申请日：1994-12-23

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  FRISBIE, Jeffery, S. ,  CORL, Paul, D. ,  ORTIZ, John, E.

IPC: A61B05/04

CPC classification number: A61B8/06 ,  A61B5/0422 ,  A61B5/6851 ,  A61B8/12 ,  A61B8/445 ,  A61B18/082 ,  A61B2017/00243 ,  A61B2017/00292 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/17 ,  A61F7/12 ,  A61F2007/0285 ,  A61M25/09033 ,  A61N1/056 ,  A61N1/40

Abstract: A method of diagnosing and treating the human or animal body comprises feeding a flexible guide wire (10) along a blood vessel in the human or animal body and epicardially mapping the electrocardiographic signals by means of electrodes (19) secured to the guide wire (10). The method of diagnosing and treating the human or animal body may include the step of ablating selected body tissue by establishing a DC or radio frequency current through the body tissue between a pair of electrodes (19) in which at least one of the electrodes (19) is located on the guide wire (10). The method may also include passing flowable material to or from selected tissue by means of a catheter passed over the guide wire (10). The method may optionally include sensing the velocity of blood flow in the blood vessel or the temperature of selected body tissue by means of a sensor (58) mounted on the guide wire (10).

Abstract translation: 一种诊断和治疗人体或动物体的方法包括沿人体或动物体内的血管喂食柔性引导线（10），并通过固定在引导线（10）上的电极（19）来心电图映射心电图信号 ）。 诊断和治疗人或动物体的方法可以包括通过在一对电极（19）之间建立DC或射频电流通过身体组织来消融所选择的身体组织的步骤，其中至少一个电极（19） ）位于导丝（10）上。 该方法还可以包括通过穿过导丝（10）的导管将可流动材料传送到选定组织或从所选择的组织传播。 该方法可以可选地包括通过安装在导丝（10）上的传感器（58）感测血管中的血流速度或所选身体组织的温度。

公开(公告)号：WO1997026832A1

公开(公告)日：1997-07-31

申请号：PCT/US1997000091

申请日：1997-01-09

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  FRISBIE, Jeffrey, S.

IPC: A61B17/14

CPC classification number: A61B17/221 ,  A61B2017/2215

Abstract: This invention is an apparatus for the treatment of a thrombotic occlusion (121) in a vessel of a patient comprising a flexible elongate tubular sheath (12) having proximal (13) and distal (14) extremities. A relatively large lumen (16) defined by a thin flexible wall extends from the proximal extremity (13) to the distal extremity (14) of the tubular sheath (12) so that the distal extremity is open. An occlusion disruption device (36) is slidably and rotatably disposed in the lumen (16) in the tubular sheath (12) and having proximal (38) and distal (39) extremities. The shaft has a guide wire lumen (41) extending from the proximal extremity (38) to the distal extremity (39). Disruption elements (47) are secured to the distal extremity (39) of the shaft (37) which when rotated disrupt the thrombotic occlusion (121) by causing it to break into pieces. Suction is applied to the lumen (16) in the tubular sheath (12) to aspirate pieces into the large lumen (16) of the tubular sheath to remove them from the vessel of the patient.

Abstract translation: 本发明是用于治疗患者容器中的血栓闭塞（121）的装置，其包括具有近端（13）和远端（14）端部的柔性细长管状护套（12）。 由薄的柔性壁限定的相当大的腔（16）从管状护套（12）的近端（13）延伸到远端（14），使得远端是敞开的。 咬合破坏装置（36）可滑动地且可旋转地设置在管状护套（12）中的内腔（16）中，并且具有近端（38）和远端（39）的末端。 轴具有从近端（38）延伸到远端（39）的导丝管腔（41）。 破坏元件（47）被固定到轴（37）的远端（39），当轴旋转时，其通过使其破裂成破裂血栓闭塞（121）。 吸管被施加到管状护套（12）中的内腔（16），以将片抽吸到管状护套的大腔（16）中，以将其从患者的血管中移出。

公开(公告)号：WO1997000434A1

公开(公告)日：1997-01-03

申请号：PCT/US1996006136

申请日：1996-05-01

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  COWAN, Mark, W.

IPC: G01L19/04

CPC classification number: G01L9/065

Abstract: A microminiature piezoresistive pressure transducer (12) has first (RA) and second (RB) variable resistive elements. Circuitry (51) is coupled to the variable resistive elements of the transducer, and includes third (RF1) and fourth (RF2) fixed resistances of known values. The first (RA) and third (RF1) elements are coupled to an amplifier (61) and analog-to-digital converter (41), and the second (RB) and fourth (RF2) elements are coupled to a separate and independent amplifier (76) and analog-to-digital converter (42). Thus, the analog-to-digital converters (41, 42) have indepedent outputs with digitized voltages thereon, having a pressure component and a temperature component. A computer (46) coupled to the outputs of the analog-to-digital converters (41, 42) ascertains the unknown first (RA) and second (RB) variable resistances as independent variable resistance elements in solving a set of equations having these variable resistances elements as unknowns and pressure and temperature as the remaining unknowns to provide a temperature compensated pressure value as measured by the microminiature pressure transducer (12).

Abstract translation: 微型压阻式压力传感器（12）具有第一（RA）和第二（RB）可变电阻元件。 电路（51）耦合到换能器的可变电阻元件，并且包括已知值的第三（RF1）和第四（RF2）固定电阻。 第一（RA）和第三（RF1）元件耦合到放大器（61）和模拟 - 数字转换器（41），并且第二（RB）和第四（RF2）元件耦合到单独和独立的放大器 （76）和模数转换器（42）。 因此，模数转换器（41,42）具有其上具有数字化电压的独立输出，具有压力分量和温度分量。 耦合到模数转换器（41,42）的输出的计算机（46）在求解具有这些变量的一组方程中确定未知第一（RA）和第二（RB）可变电阻作为独立的可变电阻元件 电阻元件作为未知数，压力和温度作为剩余未知数，以提供由微型压力传感器（12）测量的温度补偿压力值。

公开(公告)号：WO1995006964A1

公开(公告)日：1995-03-09

申请号：PCT/US1994008885

申请日：1994-08-05

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  OBARA, Robert, Z.

IPC: H01R17/18

CPC classification number: A61N1/02 ,  A61N1/04 ,  H01R24/58 ,  H01R35/00 ,  H01R2107/00 ,  Y10S439/909 ,  Y10T403/58 ,  Y10T403/599

Abstract: Rotary connector (11) for use with a flexible elongate member (12) having electrical properties and having a proximal extremity (16) with at least first and second conductive spaced-apart sleeves (26, 27) provided thereon. A housing (31) is provided having a bore (32) therein. First and second spaced-apart conductive disks (61) are disposed in said bore. The disks are adapted to have the proximal extremity of the flexible elongate member extend therethrough and to have the conductive sleeves be in contact with the conductive disks while permitting rotation of the flexible elongate member, a push button clamping assembly (81) is carried by the housing for retaining the proximal extremity of the flexible elongate member in the housing. Leads (71) are connected to the conductive disks.

Abstract translation: 旋转连接器（11），其与具有电性能的柔性细长构件（12）一起使用并且具有近端（16），其上设置有至少第一和第二导电间隔开的套筒（26,27）。 设置有在其中具有孔（32）的壳体（31）。 第一和第二间隔开的导电盘（61）设置在所述孔中。 盘适于使柔性细长构件的近端延伸穿过其中，并且使得导电套与导电盘接触，同时允许柔性细长构件的旋转，按钮夹紧组件（81）由 用于将柔性细长构件的近端保持在壳体中的壳体。 引线（71）连接到导电盘。

公开(公告)号：WO1993017623A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001868

申请日：1993-03-03

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  FRISBIE, Jeffrey ,  NASSI, Menahem, F.

IPC: A61B08/12

CPC classification number: A61B8/06 ,  A61B8/12 ,  A61B8/445

Abstract: A Doppler guide wire having an inflatable balloon (31) which is inflatable with a balloon inflation medium. An elongate flexible member having proximal and distal extremities. An ultrasonic transducer (16) is secured to the distal extremity of the elongate flexible member. The inflatable balloon (31) is mounted on the distal extremity of the elongate flexible member proximal of the ultrasonic transducer (16). Conductors (22 and 23) are connected to the ultrasonic transducer (16) and extend along the length of the elongate flexible member.

公开(公告)号：WO1996020636A1

公开(公告)日：1996-07-11

申请号：PCT/US1995014410

申请日：1995-11-17

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  FRISBIE, Jeffrey, S. ,  KURSE, Ravi, S. ,  CHECHELSKI, Victor

IPC: A61B05/00

CPC classification number: A61M25/09 ,  A61B17/22012 ,  A61B17/3207 ,  A61B2017/22001 ,  A61M2025/09083 ,  A61M2025/09108

Abstract: An intravascular guide wire (11) comprising a flexible elongate member (12) having proximal and distal extremities. A flexible elongate tubular member (21) is disposed coaxially on the flexible elongate member (12) and has proximal and distal extremities. The proximal extremity of the flexible elongate tubular member (21) is bonded to the proximal extremity of the flexible elongate member (12) to prevent axial movement relative to the flexible elongate tubular member (21) so that a portion of the proximal extremity of the flexible elongate member (12) remains free. A coil assembly (31) is secured to the distal extremity of the flexible elongate member (12).

Abstract translation: 一种血管内导丝（11），其包括具有近端和远端的柔性细长构件（12）。 柔性细长管状构件（21）同轴地设置在柔性细长构件（12）上并且具有近端和远端。 柔性细长管状构件（21）的近端被接合到柔性细长构件（12）的近端，以防止相对于柔性细长管状构件（21）的轴向移动，使得近端的一部分 柔性细长构件（12）保持自由。 线圈组件（31）固定到柔性细长构件（12）的远端。

公开(公告)号：WO1996007351A1

公开(公告)日：1996-03-14

申请号：PCT/US1995009898

申请日：1995-08-04

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  CORL, Paul, D. ,  OBARA, Robert, Z. ,  ORTIZ, John, E.

IPC: A61B05/00

CPC classification number: G01L19/141 ,  A61B5/0215 ,  A61B5/6851 ,  A61B8/06 ,  A61B8/12 ,  A61M25/09 ,  A61M25/10 ,  A61M2025/0002 ,  A61M2025/09008 ,  A61M2025/09083 ,  G01L9/0054 ,  G01L19/0084 ,  G01L19/147 ,  G01L19/149

Abstract: This invention is a guidewire (21) having pressure sensing capabilities for measuring pressure of a liquid in a vessel comprising a flexible elongate member (41) and having proximal (42) and distal (43) extremities, and having an outside diameter of 0.018'' or less. The distal extremity of said flexible elongate member (41) is adapted to be disposed in the liquid in said vessel. A housing (51) is carried by the flexible elongate member (41) and has a diameter substantially the same as the diameter of the flexible elongate member (41). The housing (51) has a space therein with a pressure sensor (76) mounted in the housing space in the housing. The pressure sensor (76) has a diaphragm (79) formed in a crystal (77) of semiconductor material, that is sensitive to changes in pressure of the liquid in the vessel. The diaphragm (79) is rectangular in shape and is mounted in a well (84), and is bordered by a rim (86) surrounding the well (84). A backing plate (78) is formed of an insulating material bonded to the crystal (77) and serves to reinforce the rim (86) of the crystal (77). The backing plate (78) has a cavity (101) therein underlying the diaphragm and is in substantial registration with the diaphragm (79). The cavity (101) serves as a pressure reference.

Abstract translation: 本发明是具有用于测量容器中的液体的压力的导丝（21），其包括柔性细长构件（41）并且具有近端（42）和远端（43）的末端，并具有0.018' ' 或更少。 所述柔性细长构件（41）的远端适于设置在所述容器中的液体中。 壳体（51）由柔性细长构件（41）承载，并且具有与柔性细长构件（41）的直径基本相同的直径。 壳体（51）具有其中安装有壳体中的容纳空间的压力传感器（76）的空间。 压力传感器（76）具有形成在半导体材料的晶体（77）中的膜片（79），其对容器中的液体的压力变化敏感。 隔膜（79）的形状为矩形，并且安装在井（84）中，并且围绕井（84）的边缘（86）邻接。 背板（78）由结合到晶体（77）上的绝缘材料形成，用于加强晶体（77）的边缘（86）。 背板（78）在隔膜下方具有空腔（101），并且与隔膜（79）基本对齐。 空腔（101）用作压力基准。

公开(公告)号：WO1995008294A1

公开(公告)日：1995-03-30

申请号：PCT/US1994010472

申请日：1994-09-16

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  MAH, Kathleen

IPC: A61B06/00

CPC classification number: A61M25/0905 ,  Y10S604/905

Abstract: This invention is a flexible elongate extension device (16) for use with a flexible elongate member (12) having proximal and distal extremities, comprising a flexible elongate extension member having proximal and distal extremities. A sleeve (21) is secured to the distal extremity. A thermoplastic adhesive is disposed in the sleeve.

Abstract translation: 本发明是用于与具有近端和远端的柔性细长构件（12）一起使用的柔性细长延伸装置（16），包括具有近端和远端的柔性细长延伸构件。 套筒（21）固定到远端。 热塑性粘合剂设置在套筒中。

公开(公告)号：WO1995019049A1

公开(公告)日：1995-07-13

申请号：PCT/US1995000086

申请日：1995-01-05

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  CORL, Paul, D. ,  PAO, Michael, C. ,  BARLETTA, Vincent, A. ,  CHECHELSKI, Victor

IPC: H01L41/08

CPC classification number: B06B1/0655 ,  A61B8/06 ,  A61B8/12 ,  B06B1/0644 ,  Y10T29/42

Abstract: Ultrasonic transducer with a selectable beamwidth comprising a body of piezoelectric material in the form of an annulus (21) having an outer diameter D and a thickness T. The body has proximal and distal generally planar parallel surfaces and a centrally disposed hole extending therethrough. The body has a cylindrical wall with a width W extending from the hole to the outer diameter. The transducer is capable of operating at low and high resonance being determined by the diameter D and an aspect ratio of D/T and the high frequency resonance being determined by the thickness T and an aspect ratio of W/T.

Abstract translation: 具有可选择的波束宽度的超声波换能器包括具有外径D和厚度T的环形物（21）形式的压电材料体。主体具有近端和远端大致平坦的平行表面和延伸穿过其的中心设置的孔。 主体具有从孔延伸到外径的宽度W的圆柱形壁。 换能器能够以低和高谐振工作，由直径D和D / T的高宽比和高频共振由厚度T和宽高比W / T确定。

公开(公告)号：WO1995009458A1

公开(公告)日：1995-04-06

申请号：PCT/US1994010546

申请日：1994-09-16

Applicant: CARDIOMETRICS, INC.

Inventor： CARDIOMETRICS, INC. ,  ORTIZ, John, E.

IPC: H01R17/18

CPC classification number: H01R24/58 ,  H01R39/64 ,  H01R2107/00

Abstract: Rotary connector (12) for use with a small diameter flexible elongate member (13) having electrical capabilities and having a proximal extremity (16) with at least first and second spaced-apart conductive sleeves (26) thereon. The rotary connector is comprised of a housing (31) and at least first and second spaced-apart contact members (41) mounted in the housing. The housing and the first and second contact members have passages therein through which the proximal extremity of the flexible elongate member can extend to place the first and second conductive sleeves in contact with the contact members. A clamping assembly means is carried by the housing for retaining the proximal extremity of the flexible elongate member in the housing while permitting rotation of the flexible elongate member with respect to the housing.

Abstract translation: 旋转连接器（12），用于具有电能的小直径柔性细长构件（13），并具有近端（16），其上具有至少第一和第二间隔开的导电套管（26）。 旋转连接器包括壳体（31）和安装在壳体中的至少第一和第二间隔开的接触构件（41）。 壳体和第一和第二接触构件具有通道，柔性细长构件的近端可通过该通道延伸，以使第一和第二导电套与接触构件接触。 夹紧装置由壳体承载，用于将柔性细长构件的近端保持在壳体中，同时允许柔性细长构件相对于壳体旋转。