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    USE OF STEM CELLS TO PREVENT NEURONAL DIEBACK
    1.
    发明申请
    USE OF STEM CELLS TO PREVENT NEURONAL DIEBACK 审中-公开
    使用干细胞来预防神经元损伤

    公开(公告)号：WO2010028249A1

    公开(公告)日：2010-03-11

    申请号：PCT/US2009/056046

    申请日：2009-09-04

    Applicant: ABT HOLDING COMPANY ,  CASE WESTERN RESERVE UNIVERSITY ,  BUSCH, Sarah, A. ,  HORN, Kevin, P. ,  MAYS, Robert, W. ,  SILVER, Jerry

    Inventor： BUSCH, Sarah, A. ,  HORN, Kevin, P. ,  MAYS, Robert, W. ,  SILVER, Jerry

    IPC: A01N65/00

    CPC classification number: A61K35/28 ,  A61K35/12 ,  A61K35/30 ,  A61K35/545 ,  A61K2035/124 ,  C12N5/0607

    Abstract: The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction ("dieback") that occurs as a result of the interaction of activated macrophages with dystrophic axons that are produced during nervous system acute or chronic injury. The invention is also directed to promoting axonal growth/regeneration. The invention is specifically directed to using stem cells or their secreted cellular factors, such as would be produced in conditioned cell culture medium, to ameliorate or prevent axonal dieback and/or promote growth/regeneration of axons.

    Abstract translation: 本发明一般涉及神经元损伤的治疗。 特别地，本发明旨在减少由于活化的巨噬细胞与在神经系统急性或慢性损伤期间产生的营养不良轴突的相互作用而发生的轴突回缩（“死亡”）。 本发明还涉及促进轴突生长/再生。 本发明特别涉及使用干细胞或其分泌的细胞因子，例如将在条件细胞培养基中产生的，以改善或预防轴突死亡和/或促进轴突的生长/再生。

    METHODS OF INHIBITING GLIAL SCAR FORMATION
    4.
    发明申请
    METHODS OF INHIBITING GLIAL SCAR FORMATION 审中-公开
    抑制眼睛形成的方法

    公开(公告)号：WO2004041197A2

    公开(公告)日：2004-05-21

    申请号：PCT/US2003/034806

    申请日：2003-10-31

    Applicant: CASE WESTERN RESERVE UNIVERSITY ,  GRIMPE, Barbara ,  SILVER, Jerry

    Inventor： GRIMPE, Barbara ,  SILVER, Jerry

    IPC: A61K

    CPC classification number: C12N15/113 ,  A61K31/70 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/315 ,  C12N2310/345

    Abstract: The present invention provides methods and compositions for inhibiting glial scar formation, methods and compositions for decreasing GAG content, methods and composition for decreasing proteoglycan gene expression, and methods and compositions for promoting neuronal regeneration. The present invention further provides methods of identifying additional agents that inhibit glial scar formation and/or promote neuronal regeneration.

    Abstract translation: 本发明提供用于抑制胶质瘢痕形成的方法和组合物，用于降低GAG含量的方法和组合物，用于降低蛋白聚糖基因表达的方法和组合物，以及用于促进神经元再生的方法和组合物。 本发明还提供鉴定抑制胶质瘢痕形成和/或促进神经元再生的其它试剂的方法。

    INHIBITION OF CELL GROWTH BY KERATAN SULFATE, CHONDROITIN SULFATE, DERMATAN SULFATE AND OTHER GLYCANS
    5.
    发明申请
    INHIBITION OF CELL GROWTH BY KERATAN SULFATE, CHONDROITIN SULFATE, DERMATAN SULFATE AND OTHER GLYCANS 审中-公开
    通过硫酸钙，硫酸锌，硫酸铝和其他甘油的细胞生长抑制

    公开(公告)号：WO1991006303A1

    公开(公告)日：1991-05-16

    申请号：PCT/US1990006189

    申请日：1990-10-26

    Applicant: CASE WESTERN RESERVE UNIVERSITY ,  GLIATECH, INC.

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  GLIATECH, INC. ,  SNOW, Diane, M. ,  SILVER, Jerry ,  HAREL, Adrian ,  ROUFA, Dikla

    IPC: A61K31/715

    CPC classification number: A61K31/715 ,  A61K31/70 ,  C07K16/18 ,  C12N9/2408 ,  Y02A50/472 ,  A61K2300/00

    Abstract: The present invention is directed to methods of using keratan sulfate, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, and hyaluronic acid, and molecules and compositions comprising keratan sulfate, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, and hyaluronic acid, to inhibit or prevent neurite outgrowth, i.e., axonal growth, or nerve regeneration (colectively termed herein ''nerve growth''), or glial cell migration or invasion, or regeneration, and therapeutically, where the foregoing is desired. In another embodiment of the invention, inhibitors and antagonists of keratan sulfate, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin, and hyaluronic acid, and molecules and compositions containing the same, may be used to promote nerve growth or glial cell migration or invasion, and can be administered therapeutically. Such inhibitors and antagonists include but are not limited to antibodies, degradative enzymes, lectins; and disaccharide antagonists of the receptors for keratan sulfate, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin or hyaluronate.

    Abstract translation: 本发明涉及使用硫酸角质素，硫酸软骨素，硫酸皮肤素，硫酸乙酰肝素，肝素和透明质酸的方法，以及包含硫酸角质素，硫酸软骨素，硫酸皮肤素，硫酸乙酰肝素，肝素和透明质酸的分子和组合物， 抑制或预防神经突生长，即轴突生长或神经再生（本文称为“神经生长”）或神经胶质细胞迁移或侵袭或再生，并且在治疗上需要上述内容。 在本发明的另一个实施方案中，可以使用硫酸角质素，硫酸软骨素，硫酸皮肤素，硫酸乙酰肝素，肝素和透明质酸的抑制剂和拮抗剂，以及包含其的分子和组合物来促进神经生长或神经胶质细胞迁移或侵袭 ，并且可以治疗地施用。 这些抑制剂和拮抗剂包括但不限于抗体，降解酶，凝集素; 以及硫酸角质素，硫酸软骨素，硫酸皮肤素，硫酸乙酰肝素，肝素或透明质酸的受体的二糖拮抗剂。

    COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES 审中-公开
    用于抑制大量家族磷酸酶活性的组合物和方法

    公开(公告)号：WO2013155103A1

    公开(公告)日：2013-10-17

    申请号：PCT/US2013/035831

    申请日：2013-04-09

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： LANG, Bradley, T. ,  CREGG, Jared, M. ,  SILVER, Jerry ,  WANG, Yi-lan

    IPC: A61K38/17 ,  A61K38/16 ,  A61P35/00

    CPC classification number: A61K38/465 ,  C12Y301/03048

    Abstract: A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans includes administering to the cell a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of the LAR family phosphatases without inhibiting binding to or activation the LAR family phosphatases by the proteoglycans.

    Abstract translation: 抑制和/或降低由蛋白聚糖诱导的受试者细胞中白细胞共同抗原相关（LAR）磷酸酶家族的活性，信号传导和/或功能的方法包括向细胞施用抑制一种或多种 更多的LAR家族磷酸酶的催化​​活性，信号和功能，而不抑制蛋白聚糖结合或激活LAR家族磷酸酶。

    MODULATION OF MACROPHAGE ACTIVATION
    10.
    发明申请
    MODULATION OF MACROPHAGE ACTIVATION 审中-公开
    大理石活化的调节

    公开(公告)号：WO2011106521A1

    公开(公告)日：2011-09-01

    申请号：PCT/US2011/026067

    申请日：2011-02-24

    Applicant: ABT HOLDING COMPANY ,  CASE WESTERN RESERVE UNIVERSITY ,  TING, Anthony, E. ,  MAYS, Robert, W. ,  HAMILTON, Jason, A. ,  BUSCH, Sarah, A. ,  SILVER, Jerry

    Inventor： TING, Anthony, E. ,  MAYS, Robert, W. ,  HAMILTON, Jason, A. ,  BUSCH, Sarah, A. ,  SILVER, Jerry

    IPC: C12N5/00

    CPC classification number: C12N5/0607 ,  A61K2035/122 ,  A61K2035/124

    Abstract: The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by administering cells that modulate macrophage activation. The invention is also directed to drug discovery methods to screen for agents that modulate the ability of the cells to modulate macrophage activation. The invention is also directed to cell banks that can be used to provide cells for administration to a subject, the banks comprising cells having desired potency to modulate macrophage activation.

    Abstract translation: 本发明提供了治疗与不良炎症成分相关的病理状况的方法。 本发明一般涉及通过施用调节巨噬细胞活化的细胞来减少炎症。 本发明还涉及用于筛选调节细胞调节巨噬细胞活化能力的试剂的药物发现方法。 本发明还涉及可用于提供用于给予受试者的细胞的细胞库，所述细胞库包含具有调节巨噬细胞活化的期望效力的细胞。

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