公开(公告)号：DE60209354T2

公开(公告)日：2006-10-19

申请号：DE60209354

申请日：2002-08-07

Applicant: CELLTECH R&D LTD

Inventor： DYKE JOAN ,  WATSON JOHN

IPC: C07D309/08 ,  A61K31/445 ,  A61K31/453 ,  A61P1/00 ,  A61P1/02 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12

Abstract: Compounds of the general formula (I) are described wherein R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a CF 3 , CF 2 H or CFH 2 group, provided that when one of R 1 and R 2 is a hydrogen atom, then the other is a CF 3 , CF 2 H or CFH 2 group, and the salts, solvates or hydrates thereof. Compounds of the invention are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. Compounds of the invention may be expected to be of use in medicine, especially where the avoidance of side effects, such as joint pain, is desired.

公开(公告)号：DE60209354D1

公开(公告)日：2006-04-27

申请号：DE60209354

申请日：2002-08-07

Applicant: CELLTECH R&D LTD

Inventor： DYKE JOAN ,  WATSON JOHN

IPC: C07D309/08 ,  A61K31/445 ,  A61K31/453 ,  A61P1/00 ,  A61P1/02 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07D405/12

Abstract: Compounds of the general formula (I) are described wherein R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a CF 3 , CF 2 H or CFH 2 group, provided that when one of R 1 and R 2 is a hydrogen atom, then the other is a CF 3 , CF 2 H or CFH 2 group, and the salts, solvates or hydrates thereof. Compounds of the invention are potent MMP inhibitors which advantageously do not cause tendonitis in a relevant animal model. Compounds of the invention may be expected to be of use in medicine, especially where the avoidance of side effects, such as joint pain, is desired.