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1.发明申请USE OF AN INHIBITOR OF CSF-1 ACTIVITY FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开使用CSF-1活性抑制剂治疗炎症性皮肤病
公开(公告)号：WO2005046657A3
公开(公告)日：2005-11-03
申请号：PCT/GB2004004652
申请日：2004-11-03
Applicant: CELLTECH R&D LTD , LAWSON ALASTAIR DAVID GRIFFITH , BOURNE TIMOTHY
Inventor： LAWSON ALASTAIR DAVID GRIFFITH , BOURNE TIMOTHY
IPC: A61K31/00 , A61K39/395 , C07K16/24 , A61P29/00
CPC classification number: C07K16/243 , A61K31/00 , A61K2039/505 , C07K2317/24
Abstract: The present invention provides a method for the treatment and/or prophylaxis of inflammatory bowel disease (IBD) comprising administering a therapeutically effective amount of an inhibitor of CSF-1 activity.
Abstract translation: 本发明提供了治疗和/或预防炎症性肠病（IBD）的方法，其包括给予治疗有效量的CSF-1活性抑制剂。
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公开(公告)号：WO2004072116A3
公开(公告)日：2004-11-18
申请号：PCT/GB2004000463
申请日：2004-02-06
CPC classification number: C07K16/245 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
Abstract: The invention relates to an ahumanized antibody molecule having specificity for antigenic determinants of IL-1beta, andwhich is made with CDRs from the murine antibody IC8 that are grafted into human frameworks. Methods for generating genes for grated sequence are also disclosed.
Abstract translation: 本发明涉及对IL-1β的抗原决定簇具有特异性的人源化抗体分子，其由来自鼠抗体IC8的CDR被移植到人骨架中。 还公开了用于产生磨碎序列基因的方法。
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公开(公告)号：AU2004210776A1
公开(公告)日：2004-08-26
申请号：AU2004210776
申请日：2004-02-06
Applicant: CELLTECH R&D LTD
Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1², therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
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公开(公告)号：NO20054223A
公开(公告)日：2005-11-08
申请号：NO20054223
申请日：2005-09-12
Applicant: CELLTECH R&D LTD
IPC: A61K47/48 , C07K16/24 , C12N15/13 , A61K39/395
CPC classification number: C07K16/245 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
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Patent Agency Ranking
公开(公告)号：CA2543926A1
公开(公告)日：2005-05-26
申请号：CA2543926
申请日：2004-11-03
Applicant: CELLTECH R&D LTD
Inventor： LAWSON ALASTAIR DAVID GRIFFITH , BOURNE TIMOTHY
IPC: A61K31/00 , A61K39/395 , A61P29/00 , C07K16/24
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公开(公告)号：CA2507004A1
公开(公告)日：2004-06-17
申请号：CA2507004
申请日：2003-12-01
Applicant: CELLTECH R&D LTD
Inventor： GRIFFITHS MERYN RUTH , CROMIE KAREN DOROTHY , BUTLER LISA , BROWN DEREK THOMAS , LAWSON ALASTAIR DAVID GRIFFITH , LIGHTWOOD DANIEL JOHN
IPC: C07K16/24 , G01N33/569 , G01N33/58 , G01N33/68 , G01N33/52
Abstract: The present invention provides a homogeneous assay for identifying an antibo dy producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antig en and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibo dy producing cell capable of producing an antibody which binds to the selected antigen.
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公开(公告)号：PL378412A1
公开(公告)日：2006-04-03
申请号：PL37841204
申请日：2004-02-06
Applicant: CELLTECH R&D LTD
IPC: A61K47/48 , A61K39/395 , C07K16/24 , C12N15/13
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公开(公告)号：NO20054223D0
公开(公告)日：2005-09-12
申请号：NO20054223
申请日：2005-09-12
Applicant: CELLTECH R&D LTD
Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1², therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
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公开(公告)号：CA2503888A1
公开(公告)日：2004-05-13
申请号：CA2503888
申请日：2003-10-28
Applicant: CELLTECH R&D LTD
Inventor： LAWSON ALASTAIR DAVID GRIFFITH , FINNEY HELENE MARGARET
IPC: C07K14/705 , C07K16/28 , C12N15/62 , C12N5/10 , A61K38/17
Abstract: Nucleic acids are described which code for chimeric cytoplasmic signalling molecules containing at least one cytoplasmic signalling sequence derived fr om CD134 or ICOS. The nucleic acids may be expressed in cells to produce chimer ic receptors and other proteins which are able to regulate cell activation processes. Such regulated cells are of use in medicine, for example in the treatment of infectious, inflammatory and autoimmune diseases.
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