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公开(公告)号：CA2473089A1
公开(公告)日：2003-08-28
申请号：CA2473089
申请日：2003-02-19
Applicant: CELLTECH R&D LTD
IPC: A61K31/4468 , A61P1/04 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/00 , A61P27/16 , A61P29/00 , A61P31/12 , A61P33/00 , A61P37/02 , A61P37/06 , C07D211/58 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/17 , C07C275/28 , A61K31/453 , A61K31/4535 , A61K31/4709
Abstract: Cyclic amino derivatives of formula (1) are described: (1) wherein: m and n, which may be the same or different, is each zero or the integer 1 or 2; AIk3 ~ is a covalent bond or a straight or branched C~1-6 alkylene chain; R1~ and R2~, which may be the same or different, is each a hydrogen atom or a straig ht or branched C~1-6 alkyl group; D is an optionally substituted aromatic or heteroaromatic group; E is an optionally substituted C~7-10 cycloalkyl, C~7- 10 cycloalkenyl or C~7-10 polycycloaliphatic group; and the salts, solvates, hydrates, tautomers or N-oxides thereof. The compounds are potent and selective modulators of the interaction between CXCR3 and its chemokine ligands and are thus of use in medicine, for example in the prevention or treatment of conditions involving inappropriate T-cell trafficking such as certain inflammatory, autoimmune and immunoregulatory disorders as described hereinafter.
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公开(公告)号：AU2003208423A1
公开(公告)日：2003-09-09
申请号：AU2003208423
申请日：2003-02-19
Applicant: CELLTECH R&D LTD
IPC: A61K31/4468 , A61P1/04 , A61P11/06 , A61P17/00 , A61P19/02 , A61P25/00 , A61P27/16 , A61P29/00 , A61P31/12 , A61P33/00 , A61P37/02 , A61P37/06 , C07D211/58 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/453 , A61K31/4535 , A61K31/4709 , A61K31/17 , C07C275/28
Abstract: Cyclic amino derivatives of formula (1) are described: (1) wherein: m and n, which may be the same or different, is each zero or the integer 1 or 2; Alk 3 is a covalent bond or a straight or branched C 1-6 alkylene chain; R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a straight or branched C 1-6 alkyl group; D is an optionally substituted aromatic or heteroaromatic group; E is an optionally substituted C 7-10 cycloalkyl, C 7-10 cycloalkenyl or C 7-10 polycycloaliphatic group; and the salts, solvates, hydrates, tautomers or N-oxides thereof. The compounds are potent and selective modulators of the interaction between CXCR3 and its chemokine ligands and are thus of use in medicine, for example in the prevention or treatment of conditions involving inappropriate T-cell trafficking such as certain inflammatory, autoimmune and immunoregulatory disorders as described hereinafter.
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公开(公告)号：CA2526880A1
公开(公告)日：2004-11-04
申请号：CA2526880
申请日：2004-04-08
Applicant: CELLTECH R&D LTD
Inventor： MEISSNER JOHANNES WILHELM GEOR , WATSON ROBERT JOHN , OWEN DAVID ALAN
IPC: C07D211/58 , A61K31/452 , A61P37/02 , A61P37/08 , C07D409/12
Abstract: Compounds of formula (1) wherein,m,n,R1,R2,Ra,ALK3, E and Y are as defined i n the claims, being potent and selective inhibitors of chemokine binding to th e CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammator y, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.
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公开(公告)号：AU2004232524A1
公开(公告)日：2004-11-04
申请号：AU2004232524
申请日：2004-04-08
Applicant: CELLTECH R&D LTD
Inventor： WATSON ROBERT JOHN , OWEN DAVID ALAN , MEISSNER JOHANNES WILHELM GEOR
IPC: A61P37/02 , A61P37/08 , C07D211/58 , C07D409/12 , A61K31/452
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