中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

14 records (took 0.022 seconds)

    1.
    发明专利
    未知

    公开(公告)号：DE60011940T2

    公开(公告)日：2005-07-21

    申请号：DE60011940

    申请日：2000-12-22

    Applicant: CELLTECH R&D LTD

    Inventor： LANGHAM JOHN ,  ALEXANDER PETER ,  HEAD CLIFFORD ,  LINSLEY MARSHA ,  PORTER ROBERT ,  ARCHIBALD CATHERINE ,  WARRELLOW JOHN

    IPC: C07C229/34 ,  C07C229/36 ,  C07D471/04 ,  C07C225/20 ,  C07C229/46 ,  C07D295/12 ,  A61K31/13 ,  A61K31/435 ,  A61P29/00

    Abstract: Squaric acid derivatives of formula (1) are described:whereinR1 is a group Ar1Ar2Alk- in whichAr1 is an optionally substituted aromatic or heteroaromatic group;Ar2 is an optionally substituted phenylene or nitrogen-containing six-membered heteroarylene group; and Alk is a chain-CH2-CH(R)-, -CH=C(R)-,in which R is a carboxylic acid (-CO2H) or a derivative or biostere thereof;R2 is a hydrogen atom or a C1-6 alkyl group;L1 is a covalent bond or a linker atom or group;n is zero or the integer 1;Alk1 is an optionally substituted aliphatic chain;R3 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group: and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.

    2.
    发明专利
    未知

    公开(公告)号：DE69434041T2

    公开(公告)日：2005-10-06

    申请号：DE69434041

    申请日：1994-12-21

    Applicant: CELLTECH R&D LTD

    Inventor： WARRELLOW JOHN ,  BOYD CAMPBELL ,  ALEXANDER PETER ,  EATON ANTHONY

    IPC: A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4418 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D213/64 ,  C07D231/20 ,  C07D261/12

    Abstract: Compounds of general formula (1): (1) wherein Y is a halogen atom or a group -OR1 where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 is a hydrogen or halogen atom or an -OR9 group, where R9 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl group, or a formyl, carboxamido or thiocarboxamido group; R4 is a group -(CH2)nAr, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1,2 or 3; R5 is a C3-9 carbocyclic ketone optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; R6 is a hydrogen atom or an optionally substituted alkyl group; R7 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.

    6.
    发明专利
    未知

    公开(公告)号：DE69434041D1

    公开(公告)日：2004-11-04

    申请号：DE69434041

    申请日：1994-12-21

    Applicant: CELLTECH R&D LTD

    Inventor： WARRELLOW JOHN ,  BOYD CAMPBELL ,  ALEXANDER PETER ,  EATON ANTHONY

    IPC: A61K31/41 ,  A61K31/415 ,  A61K31/42 ,  A61K31/44 ,  A61K31/4418 ,  A61P11/08 ,  A61P29/00 ,  A61P43/00 ,  C07D213/64 ,  C07D231/20 ,  C07D261/12

    Abstract: Compounds of general formula (1): (1) wherein Y is a halogen atom or a group -OR1 where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 is a hydrogen or halogen atom or an -OR9 group, where R9 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl group, or a formyl, carboxamido or thiocarboxamido group; R4 is a group -(CH2)nAr, where Ar is a monocyclic or bicyclic aryl group optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1,2 or 3; R5 is a C3-9 carbocyclic ketone optionally containing one or more heteroatoms selected from oxygen, sulphur or nitrogen atoms; R6 is a hydrogen atom or an optionally substituted alkyl group; R7 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of diseases such as asthma where an unwanted inflammatory response or muscular spasm is present.

    9.
    发明专利
    未知

    公开(公告)号：DE60011940D1

    公开(公告)日：2004-08-05

    申请号：DE60011940

    申请日：2000-12-22

    Applicant: CELLTECH R&D LTD

    Inventor： LANGHAM JOHN ,  ALEXANDER PETER ,  HEAD CLIFFORD ,  LINSLEY MARSHA ,  PORTER ROBERT ,  ARCHIBALD CATHERINE ,  WARRELLOW JOHN

    IPC: C07C229/34 ,  C07C229/36 ,  C07D471/04 ,  C07C225/20 ,  C07C229/46 ,  C07D295/12 ,  A61K31/13 ,  A61K31/435 ,  A61P29/00

    Abstract: Squaric acid derivatives of formula (1) are described:whereinR1 is a group Ar1Ar2Alk- in whichAr1 is an optionally substituted aromatic or heteroaromatic group;Ar2 is an optionally substituted phenylene or nitrogen-containing six-membered heteroarylene group; and Alk is a chain-CH2-CH(R)-, -CH=C(R)-,in which R is a carboxylic acid (-CO2H) or a derivative or biostere thereof;R2 is a hydrogen atom or a C1-6 alkyl group;L1 is a covalent bond or a linker atom or group;n is zero or the integer 1;Alk1 is an optionally substituted aliphatic chain;R3 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group: and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.

Patent Agency Ranking