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    USE OF FLJ40787, A PROTEIN INVOLVED IN COLON, COLORECTAL, OVARIAN, LUNG AND/OR LIVER CANCER
    1.
    发明申请
    USE OF FLJ40787, A PROTEIN INVOLVED IN COLON, COLORECTAL, OVARIAN, LUNG AND/OR LIVER CANCER 审中-公开
    使用FLJ40787，涉及在COLON，COLORECTAL，OVARIAN，LUNG和/或肝癌中的蛋白质

    公开(公告)号：WO2006000753A3

    公开(公告)日：2006-04-06

    申请号：PCT/GB2005002389

    申请日：2005-06-17

    Applicant: CELLTECH R&D LTD ,  STAMPS ALASDAIR

    Inventor： STAMPS ALASDAIR

    IPC: C07K14/47 ,  A61K38/17 ,  A61P35/00 ,  G01N33/50 ,  G01N33/574

    CPC classification number: A61K38/1709 ,  C07K14/47 ,  G01N33/574 ,  G01N2500/04

    Abstract: The present invention relates to new uses of FLJ40787 in the diagnosis, screening, treatment and prophylaxis of colon cancer, colorectal cancer, ovarian cancer, lung cancer and/or liver cancer cancer. The invention also provides compositions comprising FLJ40787, including vaccines, antibodies that are immunospecific for FLJ40787 and agents which interact with or modulate the expression or activity of FLJ40787 or which modulate the expression of the nucleic acid which codes for FLJ40787.

    Abstract translation: 本发明涉及FLJ40787在结肠癌，结肠直肠癌，卵巢癌，肺癌和/或肝癌癌症的诊断，筛选，治疗和预防中的新用途。 本发明还提供了包含FLJ40787的组合物，包括疫苗，针对FLJ40787免疫特异性的抗体和与FLJ40787相互作用或调节FLJ40787的表达或活性或调节编码FLJ40787的核酸表达的试剂。

    PROTEINS
    2.
    发明申请
    PROTEINS 审中-公开
    蛋白质

    公开(公告)号：WO2008104805A3

    公开(公告)日：2008-11-20

    申请号：PCT/GB2008050126

    申请日：2008-02-25

    Applicant: OXFORD GENOME SCIENCES UK LTD ,  ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    Inventor： ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    IPC: C07K14/435 ,  C07K16/18

    CPC classification number: C07K14/705 ,  A61K38/00

    Abstract: The present invention provides new polypeptides. Said polypeptides are of use in the screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer, in monitoring the effectiveness of B-cell non-Hodgkin s lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer treatment, and in drug development. Also provided are antibodies (and other affinity reagents such as Affibodies) which interact with or modulate the expression or activity of the polypeptides.

    Abstract translation: 本发明提供了新的多肽。 所述多肽可用于B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，胃癌，肝细胞癌，肺癌，淋巴白血病（特别是急性T细胞白血病），黑素瘤，骨肉瘤的筛选，诊断和预后 ，卵巢癌，胰腺癌，前列腺癌和肾细胞癌，用于监测B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，胃癌，肝细胞癌，肺癌，淋巴样白血病（特别是急性T- 细胞白血病），黑素瘤，骨肉瘤，卵巢癌，胰腺癌，前列腺癌和肾细胞癌治疗，以及药物开发。 还提供了与多肽的表达或活性相互作用或调节多肽的抗体（和其它亲和试剂如亲体）。

    EPHRIN TYPE-A RECEPTOR 10 PROTEIN
    3.
    发明申请
    EPHRIN TYPE-A RECEPTOR 10 PROTEIN 审中-公开
    EPHRIN型A受体10蛋白

    公开(公告)号：WO2009087462A3

    公开(公告)日：2009-09-03

    申请号：PCT/IB2008003634

    申请日：2008-12-24

    Applicant: OXFORD BIOTHERAPEUTICS LTD ,  ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    Inventor： ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    IPC: C07K16/28 ,  C12Q1/68 ,  G01N33/574

    CPC classification number: C07K16/28 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57492 ,  G01N33/74 ,  G01N2333/71

    Abstract: The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer, lung cancer or pancreatic cancer, for monitoring the effectiveness of bladder cancer, breast cancer, colorectal cancer, head and neck cancer, kidney cancer, lung cancer or pancreatic cancer treatment, and for drug development based on Ephrin Type-A Receptor 10 Protein.

    Abstract translation: 本发明提供膀胱癌，乳腺癌，结肠直肠癌，头颈癌，肾癌，肺癌或胰腺癌的治疗，筛选，诊断和预后的方法和组合物，用于监测膀胱癌，乳腺癌， 结直肠癌，头颈癌，肾癌，肺癌或胰腺癌治疗，以及基于Ephrin A型受体10蛋白的药物开发。

    PROTEINS
    4.
    发明申请
    PROTEINS 审中-公开
    蛋白质

    公开(公告)号：WO2008104804A3

    公开(公告)日：2009-03-26

    申请号：PCT/GB2008050125

    申请日：2008-02-26

    Applicant: OXFORD GENOME SCIENCES UK LTD ,  ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    Inventor： ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    IPC: C07K14/705 ,  G01N33/574 ,  G01N33/68

    CPC classification number: A61K39/39558 ,  C07K14/705 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3046 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/734 ,  C12Q1/6886 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57426 ,  G01N33/57438 ,  G01N33/57449 ,  Y10T436/143333

    Abstract: The present invention relates to the identification of membrane proteins associated with B-cell non-Hodgkin's lymphoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, glioblastoma, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T- cell leukaemia and chronic lymphocytic leukaemia), melanoma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer and retinoblastoma which have utility as markers and for treatment of said cancers and which also form biological targets against which antibodies such as therapeutic antibodies (or other affinity reagents) or other pharmaceutical agents can be made.

    Abstract translation: 本发明涉及与B细胞非霍奇金淋巴瘤，乳腺癌，子宫颈癌，结肠直肠癌，胃癌，成胶质细胞瘤，肝细胞癌，肺癌，淋巴白血病（特别是急性T细胞白血病和 慢性淋巴细胞白血病），黑素瘤，神经母细胞瘤，骨肉瘤，卵巢癌，胰腺癌，前列腺癌，肾细胞癌和视网膜母细胞瘤，其可用作标记物和用于治疗所述癌症，并且还形成抗体如治疗性抗体 或其他亲和试剂）或其它药剂。

    THERAPEUTIC AND DIAGNOSTIC TARGET
    7.
    发明申请
    THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
    治疗和诊断目标

    公开(公告)号：WO2013001369A2

    公开(公告)日：2013-01-03

    申请号：PCT/IB2012001680

    申请日：2012-06-28

    Applicant: OXFORD BIOTHERAPEUTICS LTD ,  ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    Inventor： ROHLFF CHRISTIAN ,  STAMPS ALASDAIR

    IPC: A61K39/00

    CPC classification number: C07K16/18 ,  A61K39/0011 ,  C07K14/435 ,  C07K16/005 ,  C07K16/2896 ,  C07K16/30 ,  C07K2317/55 ,  C07K2317/732 ,  C07K2317/77 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/566 ,  G01N33/57426 ,  G01N2500/04 ,  H01M2/0473 ,  H01M2/263 ,  H01M2/30 ,  H01M10/058

    Abstract: The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases.

    Abstract translation: 本发明提供了治疗，筛选，诊断和预后急性骨髓性白血病（AML），B细胞慢性淋巴细胞白血病，乳腺癌，结直肠癌，肾癌，头颈癌，肺癌，卵巢癌或 用于监测急性骨髓性白血病（AML），B细胞慢性淋巴细胞性白血病，乳腺癌，结肠直肠癌，肾癌，头颈癌，肺癌，卵巢癌或胰腺癌治疗以及药物开发的有效性的胰腺癌 。 本发明还提供了消耗免疫细胞以治疗炎性疾病的方法和组合物。

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