公开(公告)号：EP3325161A1

公开(公告)日：2018-05-30

申请号：EP16753501.2

申请日：2016-07-22

Applicant: Cepheid

Inventor： FROMM, David ,  PHAN, Tien ,  PICCINI, Matthew

IPC: B01L7/00

CPC classification number: F25B21/04 ,  B01L7/52 ,  B01L2200/025 ,  B01L2300/1822 ,  F25B2321/0212 ,  F25B2321/0251

Abstract: Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.

公开(公告)号：WO2022155304A1

公开(公告)日：2022-07-21

申请号：PCT/US2022/012275

申请日：2022-01-13

Applicant: CEPHEID ,  ROHRS, Charles

Inventor： LEE, Marissa ,  KOAY, Jessica ,  SOLIS, Earl ,  PICCINI, Matthew ,  CASLER JR., Richard J.

IPC: G05D23/19 ,  B01L7/00 ,  B01L1/025 ,  B01L2200/147 ,  B01L2200/148 ,  B01L2300/0663 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2300/1894 ,  B01L7/04 ,  B01L7/52 ,  B01L9/06 ,  F25B21/02 ,  G01K1/026 ,  G01K13/024 ,  G01N1/42 ,  G01N1/44 ,  G01N2035/00346 ,  G05D23/1919 ,  G05D23/1931

Abstract: Thermal control devices and methods to provide improved control, speed and efficiency in temperature cycling are provided herein. Such thermal control device and methods can include one or more active elements, such a thermoelectric cooler device, that is controlled by an algorithm that regulates a temperature distribution of an adjacent reaction-vessel according to a temperature distribution command trajectory and estimated reaction-vessel temperature distribution. Some embodiments include two active elements that are bilaterally applied to opposing sides of the reaction-vessel. In some embodiments, the estimated reaction-vessel temperature is determined based on a state of power electronics of the element and a temperature output of one or more sensors of a portion of the element and/or an ambient environment of the reaction-vessel. Methods of calibration of such systems utilizing a thermal calibrator as a proxy for the reaction-vessel are also provided herein.

公开(公告)号：WO2017019569A1

公开(公告)日：2017-02-02

申请号：PCT/US2016/043763

申请日：2016-07-22

Applicant: CEPHEID

Inventor： DORITY, Doug ,  PHAN, Tien ,  FROMM, David ,  CASLER, Rick ,  DICKENS, Dustin ,  MORITA, Stuart ,  PICCINI, Matthew

IPC: G01N35/00 ,  G01N35/10 ,  G01N33/487 ,  B01L3/00

CPC classification number: B01L7/52 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/143 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/0663 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  G01N33/4875 ,  G01N35/00871 ,  G01N35/1016 ,  G01N35/1095 ,  G01N2035/00019 ,  G01N2035/00316 ,  G01N2035/00356 ,  G01N2201/0221 ,  G01N2201/0256 ,  G01N2800/00 ,  H02P6/182 ,  H02P27/06

Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.

Abstract translation: 本文提供了改进的子组件和用于在适于接收分析盒的诊断测定系统中使用的控制方法。 这样的子组件包括：无刷DC电动机，门打开/关闭机构和盒装载机构，注射器和阀驱动机构组件，超声处理喇叭，热控制装置和光学检测/激励装置。 这样的系统还可以包括被配置为与用户的移动设备进行无线通信的通信单元，以便相对于在其中接收的测定盒接收与系统的功能有关的用户输入，并且中继与分析盒相关的诊断结果 到移动设备。

公开(公告)号：WO2017015640A1

公开(公告)日：2017-01-26

申请号：PCT/US2016/043761

申请日：2016-07-22

Applicant: CEPHEID

Inventor： FROMM, David ,  PHAN, Tien ,  PICCINI, Matthew

IPC: B01L7/00

CPC classification number: F25B21/04 ,  B01L7/52 ,  B01L2200/025 ,  B01L2300/1822 ,  F25B2321/0212 ,  F25B2321/0251

Abstract: Thermal control devices adapted to provide improved control and efficiency in temperature cycling are provided herein. Such thermal control device can include a thermoelectric cooler controlled in coordination with another thermal manipulation device to control an opposing face of the thermoelectric cooler and/or a microenvironment. Some such thermal control devices include a first and second thermoelectric cooler separated by a thermal capacitor. The thermal control devices can be configured in a planar configuration with a means for thermally coupling with a planar reaction vessel of a sample analyzer for use in thermal cycling in a polymerase chain reaction of the fluid sample in the reaction vessel. Methods of thermal cycling using such a thermal control devices are also provided.

Abstract translation: 本文提供了适于提供改进的温度循环控制和效率的热控制装置。 这种热控制装置可以包括与另一个热操纵装置配合控制的热电冷却器，以控制热电冷却器和/或微环境的相对面。 一些这样的热控制装置包括由热电容器分离的第一和第二热电冷却器。 热控制装置可以被配置成具有用于与样品分析器的平面反应容器进行热耦合的装置的平面构造，用于在反应容器中的流体样品的聚合酶链式反应中的热循环。 还提供了使用这种热控制装置的热循环方法。

公开(公告)号：EP4278241A1

公开(公告)日：2023-11-22

申请号：EP22703142.4

申请日：2022-01-13

Applicant: Cepheid

Inventor： LEE, Marissa ,  KOAY, Jessica ,  SOLIS, Earl ,  PICCINI, Matthew ,  CASLER JR., Richard J. ,  ROHRS, Charles

IPC: G05D23/19 ,  B01L7/00

公开(公告)号：EP3325975A1

公开(公告)日：2018-05-30

申请号：EP16745978.3

申请日：2016-07-22

Applicant: Cepheid

Inventor： DORITY, Doug ,  PHAN, Tien ,  FROMM, David ,  CASLER, Rick ,  DICKENS, Dustin ,  MORITA, Stuart ,  PICCINI, Matthew

IPC: G01N35/00 ,  G01N35/10 ,  G01N33/487 ,  B01L3/00

CPC classification number: B01L7/52 ,  B01L3/50273 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2200/143 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/0663 ,  B01L2300/14 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0496 ,  G01N33/4875 ,  G01N35/00871 ,  G01N35/1016 ,  G01N35/1095 ,  G01N2035/00019 ,  G01N2035/00316 ,  G01N2035/00356 ,  G01N2201/0221 ,  G01N2201/0256 ,  G01N2800/00 ,  H02P6/182 ,  H02P27/06

Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.