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    METHOD OF HYDROPHILIZATION OF TRANSPARENT OBJECTS.
    5.
    发明专利
    METHOD OF HYDROPHILIZATION OF TRANSPARENT OBJECTS. 未知

    公开(公告)号：AU2182170A

    公开(公告)日：1972-05-04

    申请号：AU2182170

    申请日：1970-11-03

    Applicant: CESKOSLOVENSKA AKADEMIE VED

    Inventor： LIM DRAHOSLAV ,  KOPECEK JINDRICH ,  VACIK JIRI

    IPC: C08F2/02 ,  C08J7/16 ,  C08J7/18 ,  G02B1/04 ,  C08G ,  C08F

    Abstract: 1289876 Polymerizing on the surface of polymer articles CESKOSLOVENSKA AKADEMIE VED 29 Oct 1970 [15 Dec 1969] 51582/70 Headings C3G and C3P [Also in Division G2] A method of hydrophilizing transparent objects (e.g. lenses and masks) made of hydrophobic organic polymers, which come into contact with water or saturated water vapour, comprises allowing the object to swell at the surface by contacting the surface with an olefinically unsaturated monomer capable of forming a hydrophilic polymer, or with a mixture of such monomers, the monomer or monomers either being liquids or being dissolved in a solvent in which the hydrophobic polymer is swellable, then polymerizing the monomer or monomers absorbed in the swollen surface, and finally mechanically working (e.g. cutting or polishing) the superficial hydrophilic layer formed. The monomers used may optionally include a further monomer which is capable of forming a hydrophobic polymer. The hydrophobic polymer from which the object is made may be, for example, polymethyl methacrylate, polystyrene, polydiallyl carbonate, polycarbonate (derived from bisphenol A), silicone rubber or polydimethyl siloxane. The monomer used may be a glycol monomethacrylate, optionally in admixture with corresponding dimethacrylate, acrylamide, methacrylamide, methyl methacrylate, butyl methacrylate, benzyl methacrylate, styrene, diallyl carbonate or acrylonitrile. Polymerization may be effected with a dissolved initiator (e.g. methyl azobisisobutyrate or diisopropyl percarbonate) or by application of radiation, e.g. U.V. or visible light, gammarays or X-rays.

    SYNTHETIC POLYMERIC DRUGS
    6.
    发明专利
    SYNTHETIC POLYMERIC DRUGS 未知

    公开(公告)号：CA1305053C

    公开(公告)日：1992-07-14

    申请号：CA498931

    申请日：1986-01-03

    Applicant: CESKOSLOVENSKA AKADEMIE VED ,  CANCER RES CAMPAIGN TECH

    Inventor： KOPECEK JINDRICH ,  REJMANOVA PAVLA ,  STROHALM JIRI ,  ULBRICH KAREL ,  RIHOVA BLANKA ,  CHYTRY VLADIMIR ,  LLOYD JOHN B ,  DUNCAN RUTH

    IPC: A61K38/00 ,  A61K20060101 ,  A61K31/00 ,  A61K31/70 ,  A61K45/00 ,  A61K47/00 ,  A61K47/48 ,  A61P35/00

    Abstract: SYNTHETIC POLYMERIC DRUGS A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moietyand an optional cross-linkage, comprises: (a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl)methacrylamide, (b) 0.2 to 20.0 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a bioactive moiety, (c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-methacryloylated aminoacid or peptide, to which are bound a determinant capable of interacting with spedific receptors on cell surfaces, (d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly attached to a similar peptide group attached to another polymer chain, and (e) optionally, as a bioassay label, 0 to 2 mol % of units derived fron N-methacryloylated tyrosinamide.

    10.
    发明专利
    未知

    公开(公告)号：IT987101B

    公开(公告)日：1975-02-20

    申请号：IT2362573

    申请日：1973-05-02

    Applicant: CESKOSLOVENSKA AKADEMIE VED

    Inventor： VACIK JIRI ,  KOPECEK JINDRICH

    IPC: C08F2/04 ,  G02C7/04 ,  C08F20/00 ,  C08F20/26 ,  C08F220/00 ,  C08F220/28 ,  C08F220/42 ,  C08F290/00 ,  C08F299/00 ,  C08J9/28 ,  C08G

    Abstract: 1435966 Cross-linked copolymers CESKOSLOVENSKA AKADEMIE VED 2 May 1973 1973 [2 May 1972] 20888/73 Heading C3P [Also in Division Bl] A hydrophilic cross-linked polymer which contains reactive -CN groups is produced by copolymerizing a monomer mixture containing 0À1 to 30 mol per cent of a cross-linking agent based on the total amount of the monomer mixture, a major part of which monomer mixture consists of a polyhydric alcohol ester of acrylic or methacrylic acid and acrylonitrile or methacrylonitrile, in the presence of 0 to 50% by weight of a polar solvent based on the total amount of monomer mixture and solvent. Exemplified cross-linking agents are divinyl benzene, dimethacrylates of ethylene, diethylene and triethylene glycols and diacrylates of ethylene and diethylene glycols. The polyhydric alcohol ester may be a monoacrylate or methacrylate of ethylene, diethylene or triethylene glycol and the polymerization may be carried out in the presence of various azo and peroxy initiators, optionally supplemented by u.v. radiation or ammonium persulphate. The polymer gels may be used for contact lenses, biological implants, dialysis membranes or for sorbtion of heavy metals.

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