公开(公告)号：JPH0356499A

公开(公告)日：1991-03-12

申请号：JP17648890

申请日：1990-07-05

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577

公开(公告)号：AT131873T

公开(公告)日：1996-01-15

申请号：AT90810481

申请日：1990-06-26

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：DE69024279D1

公开(公告)日：1996-02-01

申请号：DE69024279

申请日：1990-06-26

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：AU649226B2

公开(公告)日：1994-05-19

申请号：AU5809590

申请日：1990-07-02

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  DELABIE JAN ,  DEWOLF-PEETERS CHRISTIANE ,  SORG CLEMENS ,  CERLETTI NICO ,  WIESENDANGER WALTER ,  BRUEGGEN JOSEF ,  TARCSAY LAJOS

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K37/02

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：PT94575A

公开(公告)日：1991-03-20

申请号：PT9457590

申请日：1990-07-03

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  TARCSAY LAJOS ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  C07K3/20 ,  C07K15/08 ,  C12P19/34 ,  C12N5/00 ,  C07K15/28

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：PT94575B

公开(公告)日：1997-02-28

申请号：PT9457590

申请日：1990-07-03

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  TARCSAY LAJOS ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：IE70519B1

公开(公告)日：1996-12-11

申请号：IE242690

申请日：1990-07-04

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：DE69024279T2

公开(公告)日：1996-10-17

申请号：DE69024279

申请日：1990-06-26

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：GR3018521T3

公开(公告)日：1996-03-31

申请号：GR950403656

申请日：1995-12-21

Applicant: CIBA GEIGY AG

Inventor： ODINK KAREL GERRIT ,  TARCSAY LAJOS ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  CERLETTI NICO ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K38/19 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.

公开(公告)号：DK0412050T3

公开(公告)日：1996-01-29

申请号：DK90810481

申请日：1990-06-26

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  ODINK KAREL GERRIT ,  CERLETTI NICO ,  BRUEGGEN JOSEF ,  WIESENDANGER WALTER ,  SORG CLEMENS ,  DEWOLF-PEETERS CHRISTIANE ,  DELABIE JAN

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61P29/00 ,  C07K14/435 ,  C07K14/52 ,  C07K16/00 ,  C07K16/24 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/19 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  G01N33/577 ,  A61K37/02 ,  G01N33/68

Abstract: The invention concerns polypeptides with an apparent molecular weight of around 160 kD which are mediators or precursors for mediators of inflammation, derivatives thereof such as mutants and fragments, processes for their preparation, DNAs and hybrid vectors coding for said polypeptides and derivatives and host cells transformed with such hybrid vectors, polyclonal and monoclonal antibodies specific for said polypeptides or their derivatives and antibody derivatives as well as diagnostic and therapeutic methods for inflammatory conditions and Hodgkin lymphomas.