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    VERZWEIGTE AMINOOXY-AMINO-ALKAN-DERIVATE ALS ORNITHIN-DECARBOXYLASE INHIBITOREN
    3.
    发明专利
    VERZWEIGTE AMINOOXY-AMINO-ALKAN-DERIVATE ALS ORNITHIN-DECARBOXYLASE INHIBITOREN 未知

    公开(公告)号：DE69402021D1

    公开(公告)日：1997-04-17

    申请号：DE69402021

    申请日：1994-04-02

    Applicant: CIBA GEIGY AG

    Inventor： FREI JOERG ,  STANEK JAROSLAV

    IPC: A61K31/13 ,  A61P33/02 ,  A61P35/00 ,  A61P43/00 ,  C07C239/08 ,  C07C239/20

    Abstract: PCT No. PCT/EP94/01036 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Apr. 2, 1994 PCT Pub. No. WO94/24094 PCT Pub. Date Oct. 27, 1994 (I) Compounds of formula (I) in which (a) four of the radicals R1, R2, R3, R4, R5 and R6 are hydrogen and the others independently of one another are in each case C1-C2alkyl, these groups being bonded to the same carbon atom or to two different carbon atoms, or (b) five of the radicals R1, R2, R3, R4, R5 and R6 are hydrogen and the other radical is C1-C2alkyl or hydroxymethyl, or salts thereof, are described. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.

    4.
    发明专利
    未知

    公开(公告)号：NO178108C

    公开(公告)日：1996-01-24

    申请号：NO924001

    申请日：1992-10-15

    Applicant: CIBA GEIGY AG

    Inventor： STANEK JAROSLAV ,  FREI JORG ,  CARAVATTI GIORGIO

    IPC: A61K31/165 ,  A61K31/15 ,  A61K31/155 ,  A61K31/17 ,  A61K31/18 ,  A61K31/185 ,  A61K31/19 ,  A61P31/00 ,  A61P33/02 ,  A61P33/06 ,  A61P35/00 ,  A61P35/04 ,  C07C51/41 ,  C07C251/80 ,  C07C281/18 ,  C07C303/32 ,  C07C309/05 ,  C07C309/29 ,  C07C309/35 ,  C07C327/48 ,  C07C337/08 ,  C07C281/16

    Abstract: The invention relates to acid addition salts of bases of the formula I in which A, R1, R2, R3, R4, R5, X and Z have the meanings given in the description, with an acid [PA], which denotes a mono- or polybasic acid selected from carbonic acid, alkanoic acids which are unsubstituted or monosubstituted to polysubstituted, apart from formic acid, unsubstituted acetic acid, lysine and arginine; alkenoic acids which are unsubstituted or substituted, apart from unsubstituted fumaric acid, cycloalkylcarboxylic acids, arylcarboxylic acids, aryl-lower alkylcarboxylic acids in which lower alkyl is unsubstituted or substituted, aryl-lower alkenylcarboxylic acids, heterocyclylcarboxylic acids, alkanesulphonic acids which are unsubstituted or substituted, apart from unsubstituted methanesulphonic acid, aromatic sulphonic acids, alkylsulphuric acids, N-substituted sulphamic acids, organic acids without carboxyl, sulpho, sulphate or phospho groups, and further from pyrophosphoric acid and hydrogen iodide; and tautomers thereof. The acid addition salts are employed for the treatment of disorders which respond to inhibition of S-adenosylmethionine decarboxylase.

    AMINO/ALKANO DERIVATIVES OF AMINO OXIDES INHIBITING ORNITHIN DECARBOXYLASE
    6.
    发明专利
    AMINO/ALKANO DERIVATIVES OF AMINO OXIDES INHIBITING ORNITHIN DECARBOXYLASE 未知

    公开(公告)号：PL306765A1

    公开(公告)日：1995-04-18

    申请号：PL30676594

    申请日：1994-04-02

    Applicant: CIBA GEIGY AG

    Inventor： FREI JOERG ,  STANEK JAROSLAV

    IPC: A61K31/13 ,  A61P33/02 ,  A61P35/00 ,  A61P43/00 ,  C07C239/08 ,  C07C239/20

    Abstract: PCT No. PCT/EP94/01036 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Apr. 2, 1994 PCT Pub. No. WO94/24094 PCT Pub. Date Oct. 27, 1994 (I) Compounds of formula (I) in which (a) four of the radicals R1, R2, R3, R4, R5 and R6 are hydrogen and the others independently of one another are in each case C1-C2alkyl, these groups being bonded to the same carbon atom or to two different carbon atoms, or (b) five of the radicals R1, R2, R3, R4, R5 and R6 are hydrogen and the other radical is C1-C2alkyl or hydroxymethyl, or salts thereof, are described. The compounds of formula (I) and their salts are ornithine decarboxylase inhibitors.

    HYDRAZONE SALTS
    7.
    发明专利
    HYDRAZONE SALTS 未知

    公开(公告)号：SK315292A3

    公开(公告)日：1995-04-12

    申请号：SK315292

    申请日：1992-10-16

    Applicant: CIBA GEIGY AG

    Inventor： STANEK JAROSLAV ,  FREI JORG ,  CARAVATTI GIORGIO

    IPC: A61K31/165 ,  A61K31/15 ,  A61K31/155 ,  A61K31/17 ,  A61K31/18 ,  A61K31/185 ,  A61K31/19 ,  A61P31/00 ,  A61P33/02 ,  A61P33/06 ,  A61P35/00 ,  A61P35/04 ,  C07C51/41 ,  C07C251/80 ,  C07C281/18 ,  C07C303/32 ,  C07C309/05 ,  C07C309/29 ,  C07C309/35 ,  C07C327/48 ,  C07C337/08

    Abstract: The invention relates to acid addition salts of bases of the formula I in which A, R1, R2, R3, R4, R5, X and Z have the meanings given in the description, with an acid [PA], which denotes a mono- or polybasic acid selected from carbonic acid, alkanoic acids which are unsubstituted or monosubstituted to polysubstituted, apart from formic acid, unsubstituted acetic acid, lysine and arginine; alkenoic acids which are unsubstituted or substituted, apart from unsubstituted fumaric acid, cycloalkylcarboxylic acids, arylcarboxylic acids, aryl-lower alkylcarboxylic acids in which lower alkyl is unsubstituted or substituted, aryl-lower alkenylcarboxylic acids, heterocyclylcarboxylic acids, alkanesulphonic acids which are unsubstituted or substituted, apart from unsubstituted methanesulphonic acid, aromatic sulphonic acids, alkylsulphuric acids, N-substituted sulphamic acids, organic acids without carboxyl, sulpho, sulphate or phospho groups, and further from pyrophosphoric acid and hydrogen iodide; and tautomers thereof. The acid addition salts are employed for the treatment of disorders which respond to inhibition of S-adenosylmethionine decarboxylase.

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