公开(公告)号：KR820002280B1

公开(公告)日：1982-12-13

申请号：KR790002646

申请日：1979-08-03

Applicant: CIBA GEIGY AG

Inventor： SRINIVASACHARI RAAJARPA ,  VASUDEVAN SUDARSANAM

IPC: C07D417/06 ,  A61K31/425 ,  A61P33/10 ,  C07D277/42 ,  C07D295/21

Abstract: Anthelmintic benzimidazoles I(R1 = aliph. or arom. hydro carbon; R2 = H. aliph. hydrocarbon; R3, R4 = H, aliph. or cyclic or arom. hydrocarbon) were prepd. by the reaction of ophenylene diamine and compd. III (Rx = H, COOR1; Ry = CH, substituted methylene). Thus, 4.5 g S-methy1-isothiourea sulfate and 3.5 g ethy1 chloroformate were reacted with 4.5 g 1,2-diamino- 4 - (4-methy1-2-ethylamino-5 - thiazoloy1)-benzene to give 2-carboethoxyamino-5(6)-(4-methy1-2-methylamino-5-thiazoloy1)-benzimid azole(m.p. 250-255oC).

公开(公告)号：MA18688A1

公开(公告)日：1980-10-01

申请号：MA18748

申请日：1979-08-01

Applicant: CIBA GEIGY AG

Inventor： VASUDEVAN SUDARSANAM ,  SRINNIVASACHARI RAJAPPA

IPC: C07D417/06 ,  A61K31/425 ,  A61P33/10 ,  C07D277/42 ,  C07D295/21

公开(公告)号：PH16641A

公开(公告)日：1983-12-05

申请号：PH22845

申请日：1979-08-02

Applicant: CIBA GEIGY AG

Inventor： SRINIVASACHARI RAJAPPA ,  VASUDEVAN SUDARSANAM

IPC: C07D417/06 ,  A61K31/425 ,  A61P33/10 ,  C07D277/42 ,  C07D295/21 ,  C07D235/04

Abstract: The invention relates to 2-carboethoxyamino-5(6)-(2-amino-5-thiazoloyl)-benzimidazole compounds with anthelmintic properties and to processes for their preparation and pharmaceutical preparations containing such compounds.