公开(公告)号：WO1988001213A1

公开(公告)日：1988-02-25

申请号：PCT/US1987002025

申请日：1987-08-14

Applicant: CLINICAL TECHNOLOGIES ASSOCIATES, INC. ,  STEINER, Solomon, S. ,  ROSEN, Robert

Inventor： CLINICAL TECHNOLOGIES ASSOCIATES, INC.

IPC: B23B05/16

CPC classification number: A61K9/1641 ,  A61K47/559

Abstract: Methods for targeting the release of an active pharmacological agent in an animal by administering that agent encapsulated in proteinoid microspheres which are stable to the environment encountered from the point of introduction until they migrate to the targeted body organs, fluids or cells and are there unstable. Orally administered delivery systems for insulin, heparin and physostigmine utilize encapsulating microspheres which are predominantly of less than about 10 microns in diameter and pass readily through the stomach wall and which are made of an acidic proteinoid that is stable and unaffected by stomach enzymes and acid, but which releases the microencapsulated agent in pharmacologically active form in the near neutral blood stream. Basic proteinoid microspheres encapsulating a dopamine redox carrier system are administered in the lower gastrointestinal tract, where they are stable, and then enter the blood stream, where the encapsulated agent is similarly released.

公开(公告)号：WO1991015997A1

公开(公告)日：1991-10-31

申请号：PCT/US1991002707

申请日：1991-04-19

Applicant: CLINICAL TECHNOLOGIES ASSOCIATES, INC.

Inventor： CLINICAL TECHNOLOGIES ASSOCIATES, INC. ,  STEINER, Solomon, S. ,  ALBALA, Bruce, J. ,  FELDSTEIN, Robert

IPC: A61B05/103

CPC classification number: A61B5/0017 ,  A61B5/11 ,  A61B5/1123 ,  A61B5/1128 ,  A61B5/6892

Abstract: A system using audio and visual information to count coughs or evaluate other discrete information, including respiration and heart rate, relating to a patient in a fixed location such as a bed (46) is disclosed. The system provides movement- and sound-based information derived from the patient's activities to a storage device (26) and subsequently to a signal processing apparatus. One embodiment of the invention includes a pressure transducer (14), a video camera (18), a directional microphone (22), and a videocassette recorder (VCR) having two audio channels. Signals obtained from the transducer (14) and microphone (22) are transmitted to the two audio channel inputs of the VCR, while movement of the patient is recorded using the video camera (18) connected to the video channel input of the VCR. Part or all of the information stored using the VCR may be transmitted to signal processing equipment and frequency filtered to determine the presence and number of coughs, and any remaining information (e.g. the video data) may be used to confirm the count. Because various conditions manifest themselves in movements having different frequency characteristics, the present system, as appropriately modified, also can be used to determine the presence of symptoms such as restlessness and thereby evaluate the effectiveness of medicines such as sedatives and hypnotics.