公开(公告)号：WO1997031598A1

公开(公告)日：1997-09-04

申请号：PCT/US1997003154

申请日：1997-02-28

Applicant: CLOSURE MEDICAL CORPORATION

Inventor： CLOSURE MEDICAL CORPORATION ,  CLARK, Jeffrey, G. ,  LEUNG, Jeffrey, C.

IPC: A61F13/00

CPC classification number: A61L24/06 ,  A61B5/14532 ,  A61B5/1455 ,  A61L24/0021 ,  C09J4/00 ,  G01J3/1804 ,  C08L35/04 ,  C08F222/32

Abstract: A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt.% to 15 wt.% of the composition; and (C) at least one acidic stabilizing agent having a pKa ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g., body tissues, includes (a) holding damaged tissue edges together to form abutted tissue surfaces; (b) applying to the abutted tissue surfaces an excessive amount of a composition containing 1) at least one monomer, which forms a medically acceptable biodegradable polymer, 2) at least one plasticizing agent; and 3) at least one acidic stabilizing agent; and (c) maintaining the surfaces in contact until the composition polymerizes to form a thick film of polymerized composition bridging the abutted tissue surfaces.

Abstract translation: 生物相容性单体组合物包括：（A）至少一种形成医学上可接受的聚合物的单体; （B）组合物中存在的至少一种增塑剂的量为组合物的0.5重量％至15重量％; 和（C）至少一种具有约1至约7的pKa电离常数的酸性稳定剂。该组合物可以应用于各种材料，并且特别适合作为体内组织粘合剂。 在体内将两个表面（例如身体组织）接合在一起的方法包括（a）将损伤的组织边缘保持在一起以形成邻接的组织表面; （b）向邻接的组织表面施加过量的组合物，其含有1）至少一种形成医学上可接受的生物可降解聚合物的单体，2）至少一种增塑剂; 和3）至少一种酸性稳定剂; 和（c）保持表面接触直到组合物聚合以形成桥接邻接组织表面的聚合组合物的厚膜。