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公开(公告)号：WO2013089721A1
公开(公告)日：2013-06-20
申请号：PCT/US2011/065024
申请日：2011-12-15
Applicant: COLGATE-PALMOLIVE COMPANY , HOURIGAN, Regina , GAFUR, Rehana , MATTAI, Jairajh , MASTERS, James , DU-THUMM, Laurence , PILCH, Shira
Inventor： HOURIGAN, Regina , GAFUR, Rehana , MATTAI, Jairajh , MASTERS, James , DU-THUMM, Laurence , PILCH, Shira
CPC classification number: A01N31/08 , A61K8/34 , A61K8/347 , A61K31/05 , A61Q11/00 , A61Q17/005 , Y02A50/473 , A01N2300/00 , A61K2300/00
Abstract: An antibacterial composition comprising thymol and totarol. This combination provides synergistic effect against gram negative and gram positive bacteria.
Abstract translation: 包含百里酚和totarol的抗菌组合物。 这种组合对革兰氏阴性和革兰氏阳性细菌具有协同作用。
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公开(公告)号：WO2011088383A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021385
申请日：2011-01-14
Applicant: COLGATE-PALMOLIVE COMPANY , SHASTRY, Ramachandra , MASTERS, James
Inventor： SHASTRY, Ramachandra , MASTERS, James
Abstract: Described herein are dentifrice compositions comprising a zinc-containing salt and carboxypeptidase, wherein the zinc-containing salt is not sequestered.
Abstract translation: 本文描述的是含有含锌盐和羧肽酶的洁牙剂组合物，其中含锌盐不被螯合。
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公开(公告)号：WO2011088199A2
公开(公告)日：2011-07-21
申请号：PCT/US2011/021112
申请日：2011-01-13
Applicant: COLGATE-PALMOLIVE COMPANY , PIMENTA, Paloma , PILCH, Shira , MASTERS, James , WON, Betty
Inventor： PIMENTA, Paloma , PILCH, Shira , MASTERS, James , WON, Betty
Abstract: An oral care composition and method are described in which the composition includes a film or a plurality of film fragments entrained in a carrier. The film or plurality of film fragments comprises zinc oxide. The composition and methods provide benefits including increased stability and shelf-life ensuring the delivery and bioavailability of zinc oxide.
Abstract translation: 描述了一种口腔护理组合物和方法，其中组合物包含夹带在载体中的膜或多个膜片段。 膜或多个膜片段包含氧化锌。 组合物和方法提供益处，包括提高稳定性和保质期，确保氧化锌的输送和生物利用度。
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4.发明申请HIGH CLEANING AND LOW ABRASION SILICA MATERIALS TO MODULATE ENTRAPMENT AND RELEASE OF HYDROPHOBIC ACTIVES IN DENTAL FORMULATIONS 审中-公开高清洁和低磨损二氧化硅材料来调节牙齿配方中的疏水活性的形成和释放
公开(公告)号：WO2011084676A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060975
申请日：2010-12-17
Applicant: COLGATE-PALMOLIVE COMPANY , PIMENTA, Paloma , PILCH, Shira , MASTERS, James
Inventor： PIMENTA, Paloma , PILCH, Shira , MASTERS, James
CPC classification number: A61K8/25 , A61K2800/28 , A61K2800/56 , A61Q11/00
Abstract: Described herein are compositions which modulate entrapment and release of flavorants and other actives in dental formulations.
Abstract translation: 本文描述的是调节牙科制剂中调味剂和其它活性物质的捕获和释放的组合物。
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公开(公告)号：WO2022072669A1
公开(公告)日：2022-04-07
申请号：PCT/US2021/052928
申请日：2021-09-30
Inventor： TEUGHELS, Wim , VERSPECHT, Tim , BERNAERTS, Kristel , QUIRYNEN, Marc , BOON, Nico , DAEP, Carlo , MASTERS, James
IPC: A61K31/702
Abstract: The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from hemolysin, N-acetyl-D-glucosamine, α-D-lactose, D-(+)-trehalose or D-(+)-raffinose and mixtures thereof; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2021203142A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/070350
申请日：2021-04-02
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： CHEN, Dandan , TRIVEDI, Harsh, Mahendra , MASTERS, James
IPC: G01N33/566 , A61Q11/00 , A61K8/27 , A61K8/365 , G01N2500/04 , G01N2500/10
Abstract: Methods for identifying a composition that neutralizes toxicity of a lipopolysaccharide are disclosed. The methods comprise comparing the amount of cytokine and/or prostaglandin E2 secreted by cells that have Toll-like receptors activated by a lipopolysaccharide in the presence or absence of a test composition. Methods of neutralizing toxicity of a lipopolysaccharide in an individual's oral cavity using compositions identified neutralizing toxicity of a lipopolysaccharide are also disclosed. Method of neutralizing toxicity of a lipopolysaccharide in an individual's oral cavity using oral care compositions that comprise combinations of zinc oxide and zinc citrate are also disclosed.
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公开(公告)号：WO2013089716A1
公开(公告)日：2013-06-20
申请号：PCT/US2011/065016
申请日：2011-12-15
Applicant: COLGATE-PALMOLIVE COMPANY , HOURIGAN, Regina , MASTRULL, Jeffrey , MATTAI, Jairajh , MASTERS, James
Inventor： HOURIGAN, Regina , MASTRULL, Jeffrey , MATTAI, Jairajh , MASTERS, James
CPC classification number: A61K8/347 , A61K8/4973 , A61K2800/49 , A61K2800/74 , A61Q5/02 , A61Q11/00 , A61Q17/005 , A61Q19/10 , C11D3/48 , C11D7/261 , C11D7/267
Abstract: A composition comprising a solubilized magnolol analog comprising at least one magnolol analog chosen from propyl magnolol, isopropyl magnolol, butyl magnolol, and isobutyl magnolol, and dimethyl isosorbide. These solubilized analogs are useful in personal care, oral care, and home care compositions to provide anti-bacterial activity and reducing the expression of pro-inflammatory mediators.
Abstract translation: 一种包含溶解的木兰酚类似物的组合物，其包含至少一种选自丙基厚朴酚，异丙基厚朴酚，丁基厚朴酚和异丁基硼酸铝的厚朴酚类似物，以及二甲基异山梨醇酯。 这些溶解的类似物可用于个人护理，口腔护理和家庭护理组合物中，以提供抗细菌活性并减少促炎介质的表达。
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公开(公告)号：WO2010053492A1
公开(公告)日：2010-05-14
申请号：PCT/US2008/082954
申请日：2008-11-10
Applicant: COLGATE-PALMOLIVE COMPANY , D'AMBROGIO, Robert , PILCH, Shira , MASTERS, James
Inventor： D'AMBROGIO, Robert , PILCH, Shira , MASTERS, James
Abstract: A capsule slury including at least one coacervated capsule and at least 10 wt % humectant is disclosed. The humectant may be sorbitol, glycerin, polyethylene glycol, propylene glycol, xylitol, erythritol and/ or betaine.
Abstract translation: 公开了包含至少一个凝聚胶囊和至少10重量％湿润剂的胶囊sl药。 保湿剂可以是山梨醇，甘油，聚乙二醇，丙二醇，木糖醇，赤藓糖醇和/或甜菜碱。
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公开(公告)号：WO2020139627A1
公开(公告)日：2020-07-02
申请号：PCT/US2019/066854
申请日：2019-12-17
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： ZENOBIA, Camille , DAEP, Carlo , CHEN, Dandan , TRIVEDI, Harsh, Mahendra , MASTERS, James
Abstract: Methods of shifting biofilm composition in an individual's oral cavity are disclosed. The methods comprise applying to the individual's oral cavity an oral care composition in an amount effective to shift biofilm composition to increase the amount from healthy bacteria in biofilm relative to pathogenic bacteria in biofilm. The oral care composition comprising: zinc oxide, zinc citrate, and arginine. The shift in biofilm composition provides a balance having a greater amount of healthy bacteria in biofilm compared to pathogenic bacteria.
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10.发明申请
公开(公告)号：WO2020139617A1
公开(公告)日：2020-07-02
申请号：PCT/US2019/066791
申请日：2019-12-17
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： ZENOBIA, Camille , TRIVEDI, Harsh, Mahendra , YANG, Ying , DAEP, Carlo , MASTERS, James
IPC: C12N5/071
Abstract: An oral biology model which comprises biofilm, oral epithelial tissue and a suspension of neutrophil-like cells in media is disclosed. The biofilm, which comprises oral bacteria, is produced by culturing oral bacteria on a solid substrate. The oral epithelial tissue may be gingival epithelial tissue to model the gingival crevice or buccal epithelial tissue to model the oral check. The suspension of neutrophil-like cells in media comprises neutrophil-like cells that are differentiated HL60 cells induced to a neutrophil-like phenotype by treatment with retinoic acid. Methods of using the oral biology model to test and compare compounds and formulations or to screen compounds and formulations for their effect on release of inflammatory signals, their effect on biofilm and oral bacteria and/or their effect on the cellular components are disclosed.
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