公开(公告)号：US20160131580A1

公开(公告)日：2016-05-12

申请号：US14924080

申请日：2015-10-27

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  David S. Dandy ,  Matthew D. Stephens ,  Guangwei Yuan

IPC: G01N21/552 ,  G01N33/543 ,  G01N21/41

CPC classification number: G01N21/552 ,  G01N21/41 ,  G01N33/54373 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.

公开(公告)号：US09176059B2

公开(公告)日：2015-11-03

申请号：US13712425

申请日：2012-12-12

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  David S. Dandy ,  Matthew D. Stephens ,  Guangwei Yuan

IPC: G01N21/00 ,  G01N21/552 ,  G01N33/543

CPC classification number: G01N21/552 ,  G01N21/41 ,  G01N33/54373 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.

Abstract translation: 描述了能够直接，实时地检测和监测波导表面附近的分析物而不需要分析物的标记或标记的波导传感器。 分析和数值计算已经预测，由于分析物的存在，通过局部检测ev逝场的变化或耦合在波导外的光的变化，将能够实现高检测灵敏度。

公开(公告)号：US20150268162A1

公开(公告)日：2015-09-24

申请号：US14437039

申请日：2013-10-25

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Kevin L. Lear ,  Timothy A. Erickson

IPC: G01N21/41 ,  H01L31/105 ,  G01N21/77

CPC classification number: G01N21/4133 ,  G01N21/7703 ,  G01N2021/7793 ,  G01N2201/0833 ,  H01L31/105 ,  H01L31/1085

Abstract: An analyte-detection system has an optical waveguide with first and second cladding layers adjacent a core; a light source coupled to provide light to the waveguide; a photodetector such as a metal-semiconductor-metal, vertical PIN, or horizontal PIN photodetectors, the photodetector having an absorber configured to detect light escaping from the waveguide through the first cladding layer; multiple, separate, photocurrent collectors, where each photocurrent collector collects current from a separate portion of the photodetector absorber; and at least one current-sensing amplifier for receiving photocurrent. The photodetector absorber is an undivided absorber region for multiple photocurrent collectors. Either separate amplifiers are provided for each of the multiple photocurrent collection lines, or multiplexing logic couples selected photocurrent collectors to amplifiers, while coupling unselected photocurrent collectors to a bias generator.

Abstract translation: 分析物检测系统具有光波导，其中第一和第二包覆层与芯相邻; 耦合以向所述波导提供光的光源; 诸如金属 - 半导体 - 金属，垂直PIN或水平PIN光电检测器的光电检测器，所述光电检测器具有被配置为检测通过所述第一包层从所述波导逸出的光的吸收体; 多个分离的光电流收集器，其中每个光电流集电器从光电检测器吸收器的分开的部分收集电流; 以及用于接收光电流的至少一个电流感测放大器。 光电检测器吸收器是用于多个光电流收集器的不分开的吸收体区域。 为多个光电流采集线中的每一个提供单独的放大器，或者多路复用逻辑将所选择的光电流集电器耦合到放大器，同时将未选择的光电流集电器耦合到偏置发生器。

公开(公告)号：US09891167B2

公开(公告)日：2018-02-13

申请号：US14924080

申请日：2015-10-27

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  David S. Dandy ,  Matthew D. Stephens ,  Guangwei Yuan

IPC: G01N33/551 ,  G01N21/552 ,  G01N33/543 ,  G01N21/41

CPC classification number: G01N21/552 ,  G01N21/41 ,  G01N33/54373 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.

公开(公告)号：US09671334B2

公开(公告)日：2017-06-06

申请号：US14437039

申请日：2013-10-25

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  Timothy A. Erickson

IPC: H01J40/14 ,  G02B6/00 ,  G01N21/41 ,  G01N21/77 ,  H01L31/105 ,  H01L31/108

CPC classification number: G01N21/4133 ,  G01N21/7703 ,  G01N2021/7793 ,  G01N2201/0833 ,  H01L31/105 ,  H01L31/1085

Abstract: An analyte-detection system has an optical waveguide with first and second cladding layers adjacent a core; a light source coupled to provide light to the waveguide; a photodetector such as a metal-semiconductor-metal, vertical PIN, or horizontal PIN photodetectors, the photodetector having an absorber configured to detect light escaping from the waveguide through the first cladding layer; multiple, separate, photocurrent collectors, where each photocurrent collector collects current from a separate portion of the photodetector absorber; and at least one current-sensing amplifier for receiving photocurrent. The photodetector absorber is an undivided absorber region for multiple photocurrent collectors. Either separate amplifiers are provided for each of the multiple photocurrent collection lines, or multiplexing logic couples selected photocurrent collectors to amplifiers, while coupling unselected photocurrent collectors to a bias generator.